Darbitop Injection

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Darbitop Injection is used in the treatment of anemia that may have occurred due to chronic kidney disease or chemotherapy. It works by stimulating the bone marrow to produce more red blood cells.

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1/2

0.3 ml Injection

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General Information

Contains

Darbepoetin alfa (60mcg)

Marketer

Alniche Life Sciences Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Darbitop Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional.

Common side effects include abdominal pain, high blood pressure, rash, injection site pain, breathlessness, cough, and peripheral edema. Inform your doctor if there are symptoms of very high blood pressure, such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures).

Your doctor may get your blood tests done regularly to monitor the levels of salts (electrolytes such as potassium), hemoglobin, and blood cells in your blood. You should stop taking it and consult with a doctor if you develop shortness of breath or a skin rash.

Before taking Darbitop Injection, tell your doctor if you have heart disease, high blood pressure, or have had a seizure or stroke. If you are pregnant or breastfeeding, or plan to become pregnant, consult your doctor to make sure it is safe for you.

Uses of Darbitop Injection

Benefits of Darbitop Injection

Treatment of Anemia due to cancer chemotherapy
Low red blood cell count is termed as anemia. Cancer treatment with chemotherapy often causes many side effects, one of the major ones being anemia. Darbitop Injection stimulates the production of red blood cells in bone marrow and regulates the haemoglobin in the blood. This treats anemia in cancer patients receiving chemotherapy.

Treatment of Anemia due to chronic kidney disease
Anemia is a condition where your body does not have enough red blood cells to carry oxygen around your body. Chronic kidney disease (CKD) refers to the loss of normal kidney function over a long span of time. CKD progresses gradually over a few years but may become permanent if left untreated. CKD can lead to anemia. Darbitop Injection can boost your levels of red blood cells and reduce the symptoms of anemia such as tiredness and weakness. Taking this injection improves the quality of life.

Side effects of Darbitop Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Darbitop

Abdominal pain
High blood pressure
Rash
Injection site pain
Breathlessness
Cough
Peripheral edema
Procedural hypotension (low blood pressure)
Convulsion
Thromboembolism
Angina (heart related chest pain)

How to use Darbitop Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Darbitop Injection works

Darbitop Injection is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells.

All substitutes for Darbitop Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Darbitop Injection helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy.
It is given as a single injection under your skin; additionally, it can be given intravenously.
Your doctor may get your blood tests done regularly to monitor the levels of hemoglobin in your blood.
Stop taking Darbitop Injection and inform your doctor if you develop shortness of breath or a skin rash.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Darbitop Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Darbitop Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Darbitop Injection during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Darbitop Injection does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Darbitop Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.

Liver

CAUTION

Darbitop Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Darbitop with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Thalidomide (Oral Route)

If concurrent use is essential, watch out for symptoms such as fatigue, shortness of breath, unusual paleness, easy bruising or bleeding and consult your doctor if you experience them. They may adjust the doses as per the observations. Darbepoetin alfa may raise blood levels of Thalidomide.

Moderate

Pomalidomide (Oral Route)

If concurrent use is essential, watch out for symptoms such as unusual bleeding, swelling in one leg or arm, new or worsening chest pain or sudden shortness of breath and consult your doctor if you experience them. They may adjust the doses as per the observations.

Moderate

Lenalidomide (Oral Route)

Avoid combination if possible; if concurrent use is essential, your doctor may monitor for signs of clotting.

Mild

Telmisartan (Oral Route)

Your doctor may regularly monitor your blood pressure and potassium levels during the simultaneous use of these medicines. Telmisartan may reduce efficacy of Darbepoetin alfa.

Mild

Losartan (Oral Route)

Your doctor may regularly monitor your blood pressure and potassium levels during the simultaneous use of these medicines. Losartan may reduce efficacy of Darbepoetin alfa.

Frequently asked questions

How long does it take for Darbitop Injection to start working?

You will be able to notice an increase in the count of red blood cells (hemoglobin levels) in 2-6 weeks of starting Darbitop Injection. If you have any other concerns, consult your doctor.

Is Darbitop Injection safe to use?

Darbitop Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects and even death of the patient. It is important that you seek treatment from a doctor who is experienced in providing Darbitop Injection therapy. Follow all the directions strictly.

Other than pure red cell aplasia (PRCA), can there be other reasons for not responding to Darbitop Injection?

You may not respond to Darbitop Injection if you have deficiencies of iron, folic acid, or vitamin B12. It is important that you take measures to correct these deficiencies. Other reasons behind not responding to the treatment could be bleeding, infections, inflammation, and bone marrow fibrosis. Therefore, consult our doctor regarding the same.

Can Darbitop Injection be used in children?

Yes, Darbitop Injection is used to treat anemia due to chronic kidney disease in children who are above 1 year of age. The effectiveness of Darbitop Injection and side effects seen in children are similar to adults. However, consult your doctor if you are not sure.

Can Darbitop Injection affect blood pressure?

Yes, Darbitop Injection can affect blood pressure. During initial therapy with Darbitop Injection, blood pressure should be monitored and those who have high blood pressure should take appropriate measures to control blood pressure. Your doctor may stop Darbitop Injection if the blood pressure remains uncontrolled.

Who should not take Darbitop Injection?

Individuals who have cancer but have not been prescribed Darbitop Injection by the doctor should not take it. Additionally, patients with uncontrolled hypertension (high blood pressure), patients with a history of anemia called pure red cell aplasia (PRCA) that starts after treatment with Darbitop Injection or other erythropoietin medicines, and patients with a history of serious allergic reaction to this medicine should not take this medicine.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Erythropoiesis-Stimulating Agents (ESAs)

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Kaushansky K, Kipps TJ. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1071-72.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 358-59.
Darbepoetin alfa. Milton Road, Cambridge: Amgen Ltd.; 2001 [revised Sep. 2017]. [Accessed 23 Jan. 2019] (online) Available from:
Darbepoetin alfa. Thousand Oaks, CA: Amgen Inc.; 2001. [Accessed 07 Apr. 2019] (online) Available from:
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Darbepoetin. [Accessed 17 Jun. 2023] (online) Available from:
Darbepoetin alfa [Prescribing Information]. Thousand Oaks, California: Amgen Inc.; 2019. [Accessed 17 Jun. 2023] (online) Available from:
Aranesp Injection (Darbepoetin alfa) [Product Information]. [Accessed 17 Jun. 2023] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alniche Life Sciences Pvt Ltd
Address: Alniche Life Sciences Pvt. Ltd., S-14, 2nd Floor, Janta Market Rajouri Garden, New Delhi – 110 027

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Darbitop Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Darbitop Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Darbitop Injection

Benefits of Darbitop Injection

Side effects of Darbitop Injection

How to use Darbitop Injection

How Darbitop Injection works

All substitutes for Darbitop Injection

Cresp 60mcg Injection

Dargen 60 Injection

Darba 60mcg Injection

Darbotin 60 Injection

Darbelife 60mcg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Thalidomide (Oral Route)

Pomalidomide (Oral Route)

Lenalidomide (Oral Route)

Telmisartan (Oral Route)

Losartan (Oral Route)

Frequently asked questions

How long does it take for Darbitop Injection to start working?

Is Darbitop Injection safe to use?

Other than pure red cell aplasia (PRCA), can there be other reasons for not responding to Darbitop Injection?

Can Darbitop Injection be used in children?

Can Darbitop Injection affect blood pressure?

Who should not take Darbitop Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests