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Darbex 40mcg Injection

Darbepoetin alfa (40mcg)

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Stored between 2-8°C

Darbex 40mcg Injection is used in the treatment of anemia that may have occurred due to chronic kidney disease or chemotherapy. It works by stimulating the bone marrow to produce more red blood cells.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 21 Sep 2025 | 05:44 PM (IST)

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General Information

Contains

Darbepoetin alfa (40mcg)

Marketer

UTH Healthcare

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Darbex 40mcg Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional.

Common side effects include abdominal pain, high blood pressure, rash, injection site pain, breathlessness, cough, and peripheral edema. Inform your doctor if there are symptoms of very high blood pressure, such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures).

Your doctor may get your blood tests done regularly to monitor the levels of salts (electrolytes such as potassium), hemoglobin, and blood cells in your blood. You should stop taking it and consult with a doctor if you develop shortness of breath or a skin rash.

Before taking Darbex 40mcg Injection, tell your doctor if you have heart disease, high blood pressure, or have had a seizure or stroke. If you are pregnant or breastfeeding, or plan to become pregnant, consult your doctor to make sure it is safe for you.

Uses of Darbex Injection

Benefits of Darbex Injection

Treatment of Anemia due to cancer chemotherapy
Low red blood cell count is termed as anemia. Cancer treatment with chemotherapy often causes many side effects, one of the major ones being anemia. Darbex 40mcg Injection stimulates the production of red blood cells in bone marrow and regulates the haemoglobin in the blood. This treats anemia in cancer patients receiving chemotherapy.

Treatment of Anemia due to chronic kidney disease
Anemia is a condition where your body does not have enough red blood cells to carry oxygen around your body. Chronic kidney disease (CKD) refers to the loss of normal kidney function over a long span of time. CKD progresses gradually over a few years but may become permanent if left untreated. CKD can lead to anemia. Darbex 40mcg Injection can boost your levels of red blood cells and reduce the symptoms of anemia such as tiredness and weakness. Taking this injection improves the quality of life.

Side effects of Darbex Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Darbex

Abdominal pain
High blood pressure
Rash
Injection site pain
Breathlessness
Cough
Peripheral edema
Procedural hypotension (low blood pressure)
Convulsion
Thromboembolism
Angina (heart related chest pain)

How to use Darbex Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Darbex Injection works

Darbex 40mcg Injection is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells.

All substitutes for Darbex 40mcg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Darbex 40mcg Injection helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy.
It is given as a single injection under your skin; additionally, it can be given intravenously.
Your doctor may get your blood tests done regularly to monitor the levels of hemoglobin in your blood.
Stop taking Darbex 40mcg Injection and inform your doctor if you develop shortness of breath or a skin rash.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Darbex 40mcg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Darbex 40mcg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Darbex 40mcg Injection during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Darbex 40mcg Injection does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Darbex 40mcg Injection is safe to use in patients with kidney disease. No dose adjustment of Darbex 40mcg Injection is recommended.

Liver

CAUTION

Darbex 40mcg Injection should be used with caution in patients with liver disease. Dose adjustment of Darbex 40mcg Injection may be needed. Please consult your doctor.

Interaction with drugs

Taking Darbex with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Thalidomide (Oral Route)

If concurrent use is essential, watch out for symptoms such as fatigue, shortness of breath, unusual paleness, easy bruising or bleeding and consult your doctor if you experience them. They may adjust the doses as per the observations. Darbepoetin alfa may raise blood levels of Thalidomide.

Moderate

Pomalidomide (Oral Route)

If concurrent use is essential, watch out for symptoms such as unusual bleeding, swelling in one leg or arm, new or worsening chest pain or sudden shortness of breath and consult your doctor if you experience them. They may adjust the doses as per the observations.

Moderate

Lenalidomide (Oral Route)

Avoid combination if possible; if concurrent use is essential, your doctor may monitor for signs of clotting.

Mild

Telmisartan (Oral Route)

Your doctor may regularly monitor your blood pressure and potassium levels during the simultaneous use of these medicines. Telmisartan may reduce efficacy of Darbepoetin alfa.

Mild

Losartan (Oral Route)

Your doctor may regularly monitor your blood pressure and potassium levels during the simultaneous use of these medicines. Losartan may reduce efficacy of Darbepoetin alfa.

Frequently asked questions

How long does it take for Darbex 40mcg Injection to start working?

You will be able to notice an increase in the count of red blood cells (hemoglobin levels) in 2-6 weeks of starting Darbex 40mcg Injection. If you have any other concerns, consult your doctor.

Is Darbex 40mcg Injection safe to use?

Darbex 40mcg Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects and even death of the patient. It is important that you seek treatment from a doctor who is experienced in providing Darbex 40mcg Injection therapy. Follow all the directions strictly.

Other than pure red cell aplasia (PRCA), can there be other reasons for not responding to Darbex 40mcg Injection?

You may not respond to Darbex 40mcg Injection if you have deficiencies of iron, folic acid, or vitamin B12. It is important that you take measures to correct these deficiencies. Other reasons behind not responding to the treatment could be bleeding, infections, inflammation, and bone marrow fibrosis. Therefore, consult our doctor regarding the same.

Can Darbex 40mcg Injection be used in children?

Yes, Darbex 40mcg Injection is used to treat anemia due to chronic kidney disease in children who are above 1 year of age. The effectiveness of Darbex 40mcg Injection and side effects seen in children are similar to adults. However, consult your doctor if you are not sure.

Can Darbex 40mcg Injection affect blood pressure?

Yes, Darbex 40mcg Injection can affect blood pressure. During initial therapy with Darbex 40mcg Injection, blood pressure should be monitored and those who have high blood pressure should take appropriate measures to control blood pressure. Your doctor may stop Darbex 40mcg Injection if the blood pressure remains uncontrolled.

Who should not take Darbex 40mcg Injection?

Individuals who have cancer but have not been prescribed Darbex 40mcg Injection by the doctor should not take it. Additionally, patients with uncontrolled hypertension (high blood pressure), patients with a history of anemia called pure red cell aplasia (PRCA) that starts after treatment with Darbex 40mcg Injection or other erythropoietin medicines, and patients with a history of serious allergic reaction to this medicine should not take this medicine.

Fact Box

Chemical Class

Amino Acids, Peptides Analogues

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Erythropoiesis-Stimulating Agents (ESAs)

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Kaushansky K, Kipps TJ. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1071-72.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 358-59.
Darbepoetin alfa. Milton Road, Cambridge: Amgen Ltd.; 2001 [revised Sep. 2017]. [Accessed 23 Jan. 2019] (online) Available from:
Darbepoetin alfa. Thousand Oaks, CA: Amgen Inc.; 2001. [Accessed 07 Apr. 2019] (online) Available from:
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Darbepoetin. [Accessed 17 Jun. 2023] (online) Available from:
Darbepoetin alfa [Prescribing Information]. Thousand Oaks, California: Amgen Inc.; 2019. [Accessed 17 Jun. 2023] (online) Available from:
Aranesp Injection (Darbepoetin alfa) [Product Information]. [Accessed 17 Jun. 2023] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: UTH Healthcare
Address: 1st Floor , Ganga Commerce Building , Lane No. 5 , Koregaon Park , Pune – 411 001 , India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Darbex 40mcg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Darbex 40mcg Injection

Cash on delivery

Return

Expiry after

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Darbex Injection

Benefits of Darbex Injection

Side effects of Darbex Injection

How to use Darbex Injection

How Darbex Injection works

All substitutes for Darbex 40mcg Injection

Dargen 40 Injection

Cresp 40 Injection

Darbelife 40mcg Pfs Injection

Kabidarba 40 Injection

Darbosis 40 Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Thalidomide (Oral Route)

Pomalidomide (Oral Route)

Lenalidomide (Oral Route)

Telmisartan (Oral Route)

Losartan (Oral Route)

Frequently asked questions

How long does it take for Darbex 40mcg Injection to start working?

Is Darbex 40mcg Injection safe to use?

Other than pure red cell aplasia (PRCA), can there be other reasons for not responding to Darbex 40mcg Injection?

Can Darbex 40mcg Injection be used in children?

Can Darbex 40mcg Injection affect blood pressure?

Who should not take Darbex 40mcg Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests