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Dacogen Injection

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 31 Mar 2026 | 02:31 PM (IST)
Dacogen Injection is used in the treatment of blood cancer called acute myeloid leukaemia (AML). It is also used to treat patients with myelodysplastic syndrome (MDS). It may be used to treat other conditions, as determined by the doctor.
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The content is shown in English
Dacogen Injection image
Dacogen Injection image

Product introduction

Dacogen Injection is also used with certain other medicines as part of combination chemotherapy. It is given as an injection into the vein under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, diarrhea, headache, fever and lung infection. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Dacogen Injection

Benefits of Dacogen Injection

Blood cancer
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Dacogen Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but you should discuss the side effects and benefits of this medicine with your doctor. Let your doctor know if any of the side effects bothers you.
Myelodysplastic syndrome
Dacogen Injection is used to treat myelodysplastic syndrome, a group of conditions in which the bone marrow produces blood cells that are abnormal in structure and function, and does not produce enough healthy blood cells. Dacogen Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Dacogen Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Dacogen
  • Nausea
  • Vomiting
  • Headache
  • Fever
  • Lung infection
  • Decreased white blood cell count (neutrophils)
  • Nosebleeds
  • Anemia (low number of red blood cells)
  • Low blood platelets
  • Diarrhea
  • Pneumonia

How to use Dacogen Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Dacogen Injection works

Dacogen Injection interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing and multiplying.

Quick tips

  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Dacogen Injection. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Dacogen Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Dacogen Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Dacogen Injection may cause side effects that could affect your ability to drive.
You may feel tired or weak after using Dacogen Injection this could affect your ability to drive.
Kidney

Kidney

CAUTION
Dacogen Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Dacogen Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Dacogen with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Pegfilgrastim (Injection Route)

Do not consume Decitabine from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor.
Life-threatening

Sargramostim (Injection Route)

Do not consume Decitabine from 1 day before until 1 day after taking Sargramostim. Please consult your doctor.
Life-threatening

Lenograstim (Injection Route)

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy.
Life-threatening

Natalizumab (Injection Route)

Do not consume Natalizumab with Decitabine.
Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before and until 24 hours after taking Decitabine.

Frequently asked questions

Dacogen Injection is not a vesicant and is not known to cause severe local tissue damage upon extravasation (leaking of injected Dacogen Injection into the surrounding tissues from the site of administration) when injected.
The effectiveness of Dacogen Injection depends upon several factors including the patient's clinical condition, number of treatment cycles etc. and may vary depending upon the individual response.
Yes. Hair loss (alopecia) is among the known side effects of Dacogen Injection.
Dacogen Injection comes as a powder to be to be added to fluid and injected slowly over 3 hours into a vein (slow i.v infusion) by a doctor who is experienced in giving chemotherapy medications for cancer in a hospital or a clinic.

Fact Box

Chemical Class

Triazinones

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolites
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User feedback

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: JNTL Consumer Health (India) Pvt. Ltd.
Address: LBS Marg Mulund (West), Mumbai 400080, India

Vendor Details

Country of origin: United states
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