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Clokeran 5mg Tablet 1
Clokeran 5mg Tablet 2
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Clokeran 5mg Tablet

Chlorambucil (5mg)
Genuine
Authenticity Assured
Prescription
required
NPPA Regulated
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Cold stored
Stored between 2-8°C

Product Summary :

Clokeran 5mg Tablet is an anti-cancer medicine that contains chlorambucil. It is used to treat Hodgkin’s disease, non-Hodgkin’s lymphoma, and certain blood cancers like chronic lymphocytic leukemia and Waldenstrom’s macroglobulinemia. It works by damaging cancer cells and stopping them from multiplying. Take it on an empty stomach as prescribed. It can reduce blood cell counts, so regular blood tests are important.


Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 02 Oct 2026 | 01:00 AM (IST)
₹1808 MRP ₹2053.1312% off 
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General Information

Contains

Chlorambucil (5mg)

Marketer

Natco Pharma Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Clokeran 5mg Tablet 1
Clokeran 5mg Tablet 2

Product introduction

Clokeran 5mg Tablet is used in the treatment of Hodgkin's disease, certain types of non-Hodgkin’s lymphoma, and blood cancer. It is used alone or in combination with other cancer medicines.

Clokeran 5mg Tablet should be taken on an empty stomach. Dose will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.


The most common side effects of this medicine include anemia (low number of red blood cells), decreased blood cells (red cells, white cells, and platelets), and and decreased white blood cell count. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.


Inform your doctor if you have a medical history of bleeding disorders, heart or liver disease, radiation treatment, or any infection. Many other medicines can affect, or be affected by, this medicine, so let your doctor know all medications you are using. This medicine is known to reduce the number of blood cells in your blood, thereby increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Clokeran Tablet

  • Blood cancer : It helps manage certain blood cancers, including chronic lymphocytic leukemia (CLL) and Waldenstrom’s macroglobulinemia, which involve the abnormal growth of white blood cells.
  • Hodgkin’s disease : Helps treat a type of lymphoma (blood cancer) that affects the lymphatic system, which is part of the body’s immune system.
  • Non-Hodgkin lymphoma (NHL) : Helps control certain types of lymphoma (blood cancer) in which abnormal white blood cells grow in the lymphatic system.

Benefits of Clokeran Tablet

Blood cancer
Blood cancers such as chronic lymphocytic leukemia and Waldenstrom’s macroglobulinemia involve the abnormal growth and buildup of certain white blood cells. Clokeran 5mg Tablet helps by damaging these abnormal cells and stopping them from multiplying, which helps control the disease. In chronic lymphocytic leukemia, treatment may also help reduce enlarged lymph nodes and an enlarged spleen.
Hodgkin’s disease
In Hodgkin’s disease, Clokeran 5mg Tablet is used to target cancerous lymph cells, helping shrink swollen lymph nodes and manage the condition effectively as part of combination therapy.
Non-Hodgkin lymphoma (NHL)
Non-Hodgkin’s lymphoma is a type of cancer that affects the lymphatic system and involves abnormal growth of certain white blood cells. Clokeran 5mg Tablet helps by damaging cancer cells and slowing their growth. It may be used for advanced disease or when the cancer has returned after radiation treatment.

Side effects of Clokeran Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Clokeran
  • Decreased white blood cell count (neutrophils)
  • Decreased blood cells (red cells, white cells, and platelets)
  • Bone marrow suppression

How to use Clokeran Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clokeran 5mg Tablet is to be taken on an empty stomach.

How Clokeran Tablet works

Clokeran 5mg Tablet is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Dosage

The dose of Clokeran 5mg Tablet depends on the type of cancer, your body weight, and how you respond to treatment. Take it exactly as prescribed by your doctor. It should be taken on an empty stomach, either 1 hour before food or 3 hours after food. Regular blood tests are needed during treatment, and your doctor may adjust your treatment based on the results.

Quick tips

  • Tell your doctor if you have liver problems, as your dose may need to be reduced in severe liver impairment.
  • Use appropriate contraception during treatment. Clokeran 5mg Tablet should be avoided during pregnancy, particularly during the first trimester, unless your doctor considers treatment essential.
  • Do not split or divide the tablets, and follow safe-handling instructions because Clokeran 5mg Tablet is a cytotoxic (anti-cancer) medicine.
  • Keep all appointments for regular blood tests, as Clokeran 5mg Tablet can reduce blood cell counts.
  • Do not receive live vaccines during treatment unless your doctor specifically advises otherwise.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Clokeran 5mg Tablet. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Clokeran 5mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Clokeran 5mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Clokeran 5mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

SAFE IF PRESCRIBED
Clokeran 5mg Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.
Liver

Liver

CAUTION
Clokeran 5mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
All

Interaction with drugs

Taking Clokeran with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before and until 24 hours after taking Chlorambucil. Chlorambucil may reduce the efficacy of Filgrastim.
Severe

Pegfilgrastim (Injection Route)

Do not consume Chlorambucil from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor.
Severe

Sargramostim (Injection Route)

Do not consume Chlorambucil from 1 day before until 1 day after taking Sargramostim. Please consult your doctor.
Severe

Lenograstim (Injection Route)

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy.
Severe

Molgramostim (Injection Route)

Do not consume Chlorambucil from 1 day before until 1 day after taking Molgramostim. Please consult your doctor.

Frequently asked questions

Clokeran 5mg Tablet is administered orally in tablet form.
Clokeran 5mg Tablet belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth.
No, hair loss or constipation has not been reported with the use of Clokeran 5mg Tablet.
Clokeran 5mg Tablet is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood).
Clokeran 5mg Tablet is metabolized in liver to form nontoxic compounds which are excreted in urine.
Clokeran 5mg Tablet has to be stored in a refrigerator at a temperature between 2 °C – 8 °C.

Fact Box

Chemical Class

Nitrogen mustard compounds

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1684.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 243-44.
  3. Chlorambucil. Dublin, Ireland: Aspen; 2006 [revised Mar. 2015]. [Accessed 26 Mar. 2019] (online) Available from:
  4. Chlorambucil. Research Triangle Park, NC: GlaxoSmithKline; [Accessed 26 Mar. 2019] (online) Available from:
  5. Leukeran. Dublin, Ireland: Aspen Pharma Trading Limited; 2022. [Accessed 26 Mar. 2019] (online). Available from:
100% genuine products
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User feedback

Once A Day
83%
Once A Month
8%
Twice A Day
8%
Blood cancer
50%
Hodgkin’s disease
33%
Others
17%
Poor
67%
Average
33%
No Side Effect
100%
With food
100%
Expensive
67%
Average
33%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Vendor Details

Country of origin: India
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