


Clokeran 5mg Tablet
Product Summary :
Clokeran 5mg Tablet is an anti-cancer medicine that contains chlorambucil. It is used to treat Hodgkin’s disease, non-Hodgkin’s lymphoma, and certain blood cancers like chronic lymphocytic leukemia and Waldenstrom’s macroglobulinemia. It works by damaging cancer cells and stopping them from multiplying. Take it on an empty stomach as prescribed. It can reduce blood cell counts, so regular blood tests are important.Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 02 Oct 2026 | 01:00 AM (IST)
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Product introduction
Clokeran 5mg Tablet should be taken on an empty stomach. Dose will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include anemia (low number of red blood cells), decreased blood cells (red cells, white cells, and platelets), and and decreased white blood cell count. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.
Inform your doctor if you have a medical history of bleeding disorders, heart or liver disease, radiation treatment, or any infection. Many other medicines can affect, or be affected by, this medicine, so let your doctor know all medications you are using. This medicine is known to reduce the number of blood cells in your blood, thereby increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Clokeran Tablet
- Blood cancer : It helps manage certain blood cancers, including chronic lymphocytic leukemia (CLL) and Waldenstrom’s macroglobulinemia, which involve the abnormal growth of white blood cells.
- Hodgkin’s disease : Helps treat a type of lymphoma (blood cancer) that affects the lymphatic system, which is part of the body’s immune system.
- Non-Hodgkin lymphoma (NHL) : Helps control certain types of lymphoma (blood cancer) in which abnormal white blood cells grow in the lymphatic system.
Benefits of Clokeran Tablet
Blood cancers such as chronic lymphocytic leukemia and Waldenstrom’s macroglobulinemia involve the abnormal growth and buildup of certain white blood cells. Clokeran 5mg Tablet helps by damaging these abnormal cells and stopping them from multiplying, which helps control the disease. In chronic lymphocytic leukemia, treatment may also help reduce enlarged lymph nodes and an enlarged spleen.
In Hodgkin’s disease, Clokeran 5mg Tablet is used to target cancerous lymph cells, helping shrink swollen lymph nodes and manage the condition effectively as part of combination therapy.
Non-Hodgkin’s lymphoma is a type of cancer that affects the lymphatic system and involves abnormal growth of certain white blood cells. Clokeran 5mg Tablet helps by damaging cancer cells and slowing their growth. It may be used for advanced disease or when the cancer has returned after radiation treatment.
Side effects of Clokeran Tablet
- Decreased white blood cell count (neutrophils)
- Decreased blood cells (red cells, white cells, and platelets)
- Bone marrow suppression
How to use Clokeran Tablet
How Clokeran Tablet works
Dosage
The dose of Clokeran 5mg Tablet depends on the type of cancer, your body weight, and how you respond to treatment. Take it exactly as prescribed by your doctor. It should be taken on an empty stomach, either 1 hour before food or 3 hours after food. Regular blood tests are needed during treatment, and your doctor may adjust your treatment based on the results.
Quick tips
- Tell your doctor if you have liver problems, as your dose may need to be reduced in severe liver impairment.
- Use appropriate contraception during treatment. Clokeran 5mg Tablet should be avoided during pregnancy, particularly during the first trimester, unless your doctor considers treatment essential.
- Do not split or divide the tablets, and follow safe-handling instructions because Clokeran 5mg Tablet is a cytotoxic (anti-cancer) medicine.
- Keep all appointments for regular blood tests, as Clokeran 5mg Tablet can reduce blood cell counts.
- Do not receive live vaccines during treatment unless your doctor specifically advises otherwise.
Safety advice

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Interaction with drugs
Filgrastim (Injection Route)
Pegfilgrastim (Injection Route)
Sargramostim (Injection Route)
Lenograstim (Injection Route)
Molgramostim (Injection Route)
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References
- Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1684.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 243-44.
- Chlorambucil. Dublin, Ireland: Aspen; 2006 [revised Mar. 2015]. [Accessed 26 Mar. 2019] (online) Available from:
- Chlorambucil. Research Triangle Park, NC: GlaxoSmithKline; [Accessed 26 Mar. 2019] (online) Available from:
- Leukeran. Dublin, Ireland: Aspen Pharma Trading Limited; 2022. [Accessed 26 Mar. 2019] (online). Available from:




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