Information about Chlorambucil

Chlorambucil Uses

Chlorambucil is used in the treatment of blood cancer and Hodgkin’s disease.

How Chlorambucil works

Chlorambucil is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Common side effects of Chlorambucil

Nausea, Vomiting, Mouth ulcer, Anemia (low number of red blood cells), Decreased blood cells (red cells, white cells, and platelets), Bone marrow suppression, Decreased white blood cell count, Diarrhea, Decreased white blood cell count (neutrophils)
Written By
Reviewed By
MD (Pharmacology), MBBS
Last updated
30 Jul 2022 | 10:24 AM (UTC)

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Available Medicine for Chlorambucil

CelkeranCelon Laboratories Ltd
1090 to ₹23242 variant(s)
ClokeranNatco Pharma Ltd
960 to ₹21902 variant(s)
ChloramaxGLS Pharma Ltd.
1424 to ₹23702 variant(s)

Expert advice for Chlorambucil

  • Chlorambucil should be taken one hour before a meal or two hours after a meal. 

Frequently asked questions for Chlorambucil


Q. How is Chlorambucil administered?

Chlorambucil is administered orally in tablet form.

Q. Why is Chlorambucil toxic to cancer cells/ how does Chlorambucil work?

Chlorambucil belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth.

Q. Does Chlorambucil cause hair loss/constipation?

No, hair loss or constipation has not been reported with the use of Chlorambucil.

Q. What is Chlorambucil used for?

Chlorambucil is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood).

Q. How is Chlorambucil excreted?

Chlorambucil is metabolized in liver to form nontoxic compounds which are excreted in urine.

Q. Does Chlorambucil need to be refrigerated?

Chlorambucil has to be stored in a refrigerator at a temperature between 2 °C – 8 °C.


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