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    Information about Chlorambucil

    Chlorambucil uses

    Chlorambucil is used in the treatment of blood cancer and Hodgkin’s disease.

    How chlorambucil works

    Chlorambucil is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

    Common side effects of chlorambucil

    Nausea, Vomiting, Mouth ulcer, Anemia (low number of red blood cells), Decreased blood cells (red cells, white cells, and platelets), Bone-marrow suppression, Decreased white blood cell count, Diarrhea, Decreased white blood cell count (neutrophils)
    Content Details
    Written By
    Dr. Anuj Saini
    Reviewed By
    Dr. Lalit Kanodia
    MBA (Hospital Management), MD (Pharmacology)
    Last updated on:
    18 Sep 2017 | 11:52 AM (IST)
    Want to know more?
    Read Our Editorial Policy

    Available Medicine for Chlorambucil

    • ₹1090 to ₹2325
      Celon Laboratories Ltd
      2 variant(s)
    • ₹960 to ₹2190
      Natco Pharma Ltd
      2 variant(s)
    • ₹2370
      GLS Pharma Ltd.
      1 variant(s)
    • ₹1293 to ₹2587
      Glaxo SmithKline Pharmaceuticals Ltd
      2 variant(s)
    • ₹2370
      GLS Pharma Ltd.
      1 variant(s)

    Expert advice for Chlorambucil

    • Do not receive live vaccine (such as measles, mumps, rubella and others) while using chlorambucil, and avoid contact with anyone who has recently received a live vaccine as there are chances that the virus could be passed on to you.
    • You may be regularly monitored for blood count while taking chlorambucil.
    • Do not take chlorambucil if you have recently undergone radiotherapy or received other cytotoxic agents.
    • Caution has to be followed if you have a liver or kidney problems. 
    • Regular monitoring is required if your child is having nephrotic syndrome; or if you have been prescribed high pulse dosing regimens and have a history of seizure disorder.
    • Do not take chlorambucil if you have rare hereditary problems of glucose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medication.
    • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

    Frequently asked questions for Chlorambucil


    Q. How is Chlorambucil administered?

    Chlorambucil is administered orally in tablet form

    Q. Why is Chlorambucil toxic to cancer cells/ how does Chlorambucil work?

    Chlorambucil belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth

    Q. Does Chlorambucil cause hair loss/constipation?

    No, hair loss or constipation has not been reported with the use of Chlorambucil.

    Q. What is Chlorambucil used for?

    Chlorambucil is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood)

    Q. How is Chlorambucil excreted?

    Chlorambucil is metabolized in liver to form nontoxic compounds which are excreted in urine

    Q. Does Chlorambucil need to be refrigerated?

    Chlorambucil has to be stored in a refrigerator at 2 °C – 8 °C

    Content on this page was last updated on 18 September, 2017, by Dr. Varun Gupta (MD Pharmacology)