Celkeran 5mg Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 14 Apr 2026 | 04:21 PM (IST)

Celkeran 5mg Tablet is used in the treatment of some cancers of blood and lymphatic system. It may be also used to treat other kinds of cancer, as determined by the doctor. It is used alone or in combination with other cancer medicines.

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Cold stored

Stored between 2-8°C

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General Information

Contains

Chlorambucil (5mg)

Marketer

Celon Laboratories Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Celkeran 5mg Tablet should be taken empty stomach, or 1 hour before and 2 hours after a meal. But, try to have it at the same time every day for most benefits. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include anemia (low number of red blood cells), decreased blood cells (red cells, white cells, and platelets) decreased white blood cell count, infection, nausea and vomiting. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Celkeran Tablet

Benefits of Celkeran Tablet

Blood cancer
Celkeran 5mg Tablet is used in certain types of blood cancer, such as leukemia and lymphoma, to slow the growth of abnormal cells and reduce the spread of the disease. It helps control symptoms and improve overall treatment response.

Hodgkin’s disease
In Hodgkin’s disease, Celkeran 5mg Tablet is used to target cancerous lymph cells, helping shrink swollen lymph nodes and manage the condition effectively as part of combination therapy.

Side effects of Celkeran Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Celkeran

Anemia (low number of red blood cells)
Decreased blood cells (red cells, white cells, and platelets)
Decreased white blood cell count (neutrophils)
Decreased white blood cell count
Bone marrow suppression
Nausea
Vomiting
Diarrhea
Mouth ulcer

How to use Celkeran Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Celkeran 5mg Tablet is to be taken on an empty stomach.

How Celkeran Tablet works

Celkeran 5mg Tablet is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Quick tips

Celkeran 5mg Tablet should be taken one hour before a meal or two hours after a meal.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Celkeran 5mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Celkeran 5mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Celkeran 5mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Celkeran 5mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Celkeran 5mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Careful monitoring by a doctor is important as kidney disease patients are at an increased risk of bone marrow depression and inflammation and infections of urinary bladder while taking this medicine.

Liver

CAUTION

Celkeran 5mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Celkeran with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Concomitant use is not recommended. Please consult with your doctor about appropriate gap between these two. Chlorambucil may reduce the efficacy of Cholera Vaccine (Inactivated).

Severe

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Concomitant use is not recommended. Please consult with your doctor about appropriate gap between these two. Chlorambucil may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).

Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Chlorambucil with Purified Vi Polysaccharide Typhoid Vaccine. If Chlorambucil is essential, ensure a gap of At least 6 months after discontinuing Purified Vi Polysaccharide Typhoid Vaccine. Please consult your doctor. Concurrent use may increase the risk of fatal infections.

Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Chlorambucil. Please consult with your doctor. Chlorambucil may reduce the efficacy of Filgrastim.

Severe

Pegfilgrastim (Injection Route)

Do not consume Chlorambucil from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor.

Frequently asked questions

How is Celkeran 5mg Tablet administered?

Celkeran 5mg Tablet is administered orally in tablet form.

Why is Celkeran 5mg Tablet toxic to cancer cells/ how does Celkeran 5mg Tablet work?

Celkeran 5mg Tablet belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth.

Does Celkeran 5mg Tablet cause hair loss/constipation?

No, hair loss or constipation has not been reported with the use of Celkeran 5mg Tablet.

What is Celkeran 5mg Tablet used for?

Celkeran 5mg Tablet is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood).

How is Celkeran 5mg Tablet excreted?

Celkeran 5mg Tablet is metabolized in liver to form nontoxic compounds which are excreted in urine.

Does Celkeran 5mg Tablet need to be refrigerated?

Celkeran 5mg Tablet has to be stored in a refrigerator at a temperature between 2 °C – 8 °C.

Fact Box

Chemical Class

Nitrogen mustard compounds

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1684.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 243-44.
Chlorambucil. Dublin, Ireland: Aspen; 2006 [revised Mar. 2015]. [Accessed 26 Mar. 2019] (online) Available from:
Chlorambucil. Research Triangle Park, NC: GlaxoSmithKline; [Accessed 26 Mar. 2019] (online) Available from:

User feedback

Patients taking Celkeran 5mg Tablet

Twice A Day

60%

Once A Day

40%

What are you using Celkeran Tablet for?

Others

50%

Blood cancer

50%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Celon Laboratories Ltd
Address: Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Celkeran 5mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Celkeran Tablet

Benefits of Celkeran Tablet

Side effects of Celkeran Tablet

How to use Celkeran Tablet

How Celkeran Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Cholera Vaccine (Inactivated) (Oral Route)

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Filgrastim (Injection Route)

Pegfilgrastim (Injection Route)

Frequently asked questions

How is Celkeran 5mg Tablet administered?

Why is Celkeran 5mg Tablet toxic to cancer cells/ how does Celkeran 5mg Tablet work?

Does Celkeran 5mg Tablet cause hair loss/constipation?

What is Celkeran 5mg Tablet used for?

How is Celkeran 5mg Tablet excreted?

Does Celkeran 5mg Tablet need to be refrigerated?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

User feedback

Patients taking Celkeran 5mg Tablet

What are you using Celkeran Tablet for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests