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Cafirate Injection

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 23 Jan 2026 | 10:15 AM (IST)
Cafirate Injection is a prescription medicine used in the treatment of apnea (a disorder in which breathing repeatedly stops and starts) of prematurity. It facilitates normal breathing and reduces interrupted breathing in premature newborns.
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General Information

Contains

Caffeine (20mg/ml)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store below 30°C
The content is shown in English
Cafirate Injection image
Cafirate Injection image

Product introduction

Cafirate Injection is given under the supervision of healthcare professionals. Remember, if you are breastfeeding while your infant is treated with this medicine, then do not drink coffee or take any other high caffeine product as this passes into breast milk.

Some common side effects of this medicine include mild delirium, insomnia, frequent urge to urinate, dehydration, tachycardia, and fever. Consult your doctor if these do not go away or persist for a longer duration. They may be able to suggest ways to prevent or reduce the side effects.

Uses of Cafirate Injection

  • Apnea of prematurity

Benefits of Cafirate Injection

Apnea of prematurity
In a premature baby, the part of the brain that controls breathing is not mature enough for nonstop breathing. This causes large bursts of breath followed by periods of shallow breathing or stopped breathing. This is called apnea or breathing trouble of prematurity. Cafirate Injection helps to stimulate those areas of the brain that control breathing and normalise it. It is given as an injection by a doctor or nurse.

Side effects of Cafirate Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cafirate
  • Delirium (acute confusional state)
  • Dehydration
  • Fever
  • Insomnia (difficulty in sleeping)
  • Frequent urge to urinate

How to use Cafirate Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Cafirate Injection works

Cafirate Injection is a stimulant. It works by blocking the action of certain natural substances (adenosine and phosphodiesterase) leading to stimulation of the brain and respiratory system in premature newborns. This reduces the number of episodes of interrupted breathing and helps the newborns breathe on their own.

All substitutes for Cafirate Injection

For information purposes only. Consult a doctor before taking any medicine.

Capnea Injection

by Cipla Ltd
₹267.5/injection
18% cheaper
<h3 class=bodySemiBold>Capnea Injection</h3>

Capnea Injection

by Cipla Ltd
₹535.2/injection
65% costlier
<h3 class=bodySemiBold>Capnea Injection</h3>

Cafneon 20mg/ml Injection

by Neon Laboratories Ltd
₹262.5/injection
19% cheaper
<h3 class=bodySemiBold>Cafneon 20mg/ml Injection</h3>

Quick tips

  • Cafirate Injection helps in the treatment of interrupted breathing in premature babies.
  • It is given as an injection (drip) by your doctor or nurse.
  • If you are breast-feeding while your infant is treated with Cafirate Injection, do not drink coffee or take any other high caffeine product as caffeine passes into breast milk.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Cafirate Injection. Please consult your doctor.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Cafirate Injection is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Cafirate Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

NOT RELEVANT
Not relevant, as Cafirate Injection is intended for use in hospitalized patients.
Kidney

Kidney

CAUTION
Cafirate Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Cafirate Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Cafirate with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Phenobarbitone (Oral Route)

It is recommended to avoid Caffeine after taking Phenobarbitone, especially at bedtime. Caffeine may reduce the efficacy of Phenobarbitone.
Moderate

Leflunomide (Oral Route)

Your doctor may monitor the effects of Leflunomide when taken concurrently with Caffeine. Caffeine may reduce blood levels of Leflunomide.
Moderate

Adenosine (Oral Route)

It is recommended to avoid Caffeine for at least 24 hours before taking Adenosine. Please consult your doctor accordingly. Caffeine may reduce the efficacy of Adenosine.
Moderate

Axitinib (Oral Route)

If concurrent use is essential, watch out for symptoms such as acute confusional state, difficulty in sleeping, frequent urge to urinate or fever and consult your doctor if you experience them. They may adjust the doses as per the observations. Axitinib may raise blood levels of Caffeine.
Moderate

Amoxapine (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required.

Frequently asked questions

Cafirate Injection is a medicine given to premature babies who have apnea of prematurity. This condition causes infants to stop breathing for short periods because their breathing system is not fully developed. Cafirate Injection helps stimulate the baby’s brain and lungs to improve breathing.
Cafirate Injection works by stimulating the central nervous system and the baby’s breathing center. It makes the brain more responsive to carbon dioxide and helps reduce episodes where the baby stops breathing. It also improves muscle tone and decreases fatigue of the diaphragm, the muscle that controls breathing.
Cafirate Injection should not be given to infants who are allergic or hypersensitive to caffeine, or any of the ingredients in the medicine. If a baby has shown any allergic reaction to caffeine in the past, this medicine should be avoided.
One of the most serious risks linked to Cafirate Injection is necrotizing enterocolitis (a life-threatening bowel condition) that has been reported in premature babies during clinical studies. Because of this, babies receiving this medicine must be closely monitored for abdominal bloating, vomiting, bloody stools, or sudden changes in energy levels.
No, Cafirate Injection is meant only for short-term treatment of apnea of prematurity, typically for ten to twelve days. Its safety and effectiveness for long-term use, or for other conditions such as sudden infant death syndrome (SIDS), have not been proven.
Before starting Cafirate Injection treatment, doctors should rule out other possible causes of apnea, such as infections, anemia, or lung disease. They may also need to check caffeine levels in babies who were previously given theophylline, or whose mothers consumed caffeine before delivery, since these can affect blood caffeine levels.
While the baby is on Cafirate Injection treatment, parents or caregivers should immediately contact the doctor if the baby develops a swollen belly, vomiting, bloody stools, unusual sleepiness, or seems unwell. These may be signs of serious complications such as necrotizing enterocolitis.

Fact Box

Chemical Class

Xanthine derivative

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Adenosine receptor (A1 & A2) antagonist

References

  1. O’Brien CP. Drug Addiction. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 663.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 179-83.
  3. Tulane University: School of Medicine. Caffeine. [Accessed 29 Jan. 2019] (online) Available from:
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Caffeine. [Updated 2019 Jun 30]. [Accessed 20 Feb. 2020] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205 || Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Cafirate Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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