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Amoxapine is used for the treatment of depression.

How it works

Amoxapine belongs to a class of drugs called as tricyclic antidepressant. It acts by increasing the level of chemicals (norepinephrine and serotonin) in brain that is required to maintain normal mental balance.

Common side effects

Palpitations, Increased sensitivity to light, Frequent urge to urinate, Drowsiness, Anxiety, Blurred vision, Change in appetite, Change in body weight, Confusion, Constipation, Dizziness, Dry mouth, Difficulty in urination, Fainting, Headache, Increased potassium level in blood, Increased sweating, Insomnia, Nausea, Rash, Respiratory tract infection, Restlessness, Swelling, Tremor, Unsteadiness, Fatigue, Weakness, Nightmare


Expert advice

  • Caution must be exercised as amoxapine use is associated with increased suicidal ideation and tendencies in children and young adolescent.
  • Avoid long term use of amoxapine as it may cause tardive dyskinesia (disorder resulting in involuntary, repetitive body movements).
  • Do not change your dose or stop taking amoxapine, even if you are feeling well, as this may worsen your symptoms.
  • Use of amoxapine may cause dizziness/ drowsiness; it is advisable to avoid driving or operating heavy machinery under such circumstances till you feel fine.
  • Avoid drinking alcohol as it may worsen the side effects (dizziness/drowsiness).
  • Do not start or consult a doctor if you are being treated with electroshock therapy, have epilepsy, psychosis, increased intraocular pressure or history of urinary retention.
  • Inform your doctor that you are taking amoxapine if you are or planning to undergo a surgery including dental surgery, 
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions


Q. What are the uses of amoxapine?
Amoxapine is used for the treatment of depression.
Q. How does amoxapine work?
It acts by increasing the amount of chemicals (norepinephrine and serotonin) that is required to maintain normal mental balance.
Q. Does amoxapine cause weight gain?
Amoxapine causes change in weight (increase or decrease).

Content on this page was last updated on 03 October, 2016, by Dr. Varun Gupta (MD Pharmacology)