Cabotib 40 Tablet

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 30 Jan 2026 | 03:40 PM (IST)

Cabotib 40 Tablet belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer.

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General Information

Contains

Cabozantinib (40mg)

Marketer

Glenmark Pharmaceuticals Ltd

The content is shown in English

Product introduction

Cabotib 40 Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. Take it exactly as advised by the doctor. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Fatigue, nausea, loss of appetite, taste change, and diarrhea are some of the common side effects of Cabotib 40 Tablet. It might cause high blood pressure, so the doctor may ask you for a regular check up of blood pressure. You must inform your doctor if you notice a severe skin reaction, such as skin rash or any pain, swelling, and redness of your hands and feet.

Before taking Cabotib 40 Tablet, tell your doctor if you have heart disease, liver or kidney problems, or high blood pressure. Many other medicines can affect, or be affected by, this medicine, so let your healthcare team know about all the medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during the treatment with this drug is important to avoid pregnancy.

Uses of Cabotib Tablet

Benefits of Cabotib Tablet

Treatment of Thyroid cancer
Thyroid is a butterfly-shaped gland located at the base of the neck. It produces hormones that regulate the heart rate, blood pressure, body temperature, and weight. Thyroid cancer occurs in the cells of the thyroid, and it might not cause any symptoms at first. Cabotib 40 Tablet restricts the oxygen supply of the cancer cells and stops their growth as well as further spread. It is a potent and very toxic medicine, and you should discuss its risks and benefits with your doctor. Avoid drinking alcohol or smoking while undergoing treatment with this drug, and drink plenty of water to stay hydrated.

Treatment of Liver cancer
Liver cancer is the cancer that develops in the cells of the liver called hepatocytes. There may be no symptoms during the early stages of the cancer but as the disease advances to later stages, symptoms such as weight loss, stomach pain, vomiting, and yellowed skin may appear. Cabotib 40 Tablet kills the cancer cells and prevents further growth and spread of the cancer to other unaffected areas. Drinking alcohol or smoking can worsen your condition and hinder your recovery, so avoid their use.

Side effects of Cabotib Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Cabotib

Low blood platelets
Anemia (low number of red blood cells)
Fatigue
Nausea
Diarrhea
Vomiting
Stomatitis (Inflammation of the mouth)
High blood pressure
Decreased appetite
Dyspepsia
Taste change
Palmar-plantar erythrodysesthesia syndrome
Decrease in body weight
Increased liver enzymes

How to use Cabotib Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cabotib 40 Tablet is to be taken on an empty stomach.

How Cabotib Tablet works

Cabotib 40 Tablet works by blocking the action of an abnormal protein that prompts multiplication of cancer cells, thereby slowing or stopping the spread of cancer cells.

All substitutes for Cabotib 40 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Cabotib 40 Tablet is used for the treatment of thyroid cancer.
Take it with or without food, preferably at the same time each day.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
Cabotib 40 Tablet is used for the treatment of thyroid cancer.
Take it with or without food, preferably at the same time each day.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Cabotib 40 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Cabotib 40 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Cabotib 40 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Cabotib 40 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Cabotib 40 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Cabotib 40 Tablet in patients with liver disease.

Interaction with drugs

Taking Cabotib with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Hydroxychloroquine (Oral Route)

Do not consume Hydroxychloroquine with Cabozantinib.

Life-threatening

Phenindione (Oral Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately. Your doctor may frequently monitor your blood clotting time.

Life-threatening

Warfarin (Oral Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately. Your doctor may frequently monitor your blood clotting time.

Life-threatening

Sevoflurane (Oral Route)

Do not consume Sevoflurane with Cabozantinib.

Life-threatening

Lenvatinib (Oral Route)

Do not consume Lenvatinib with Cabozantinib.

Frequently asked questions

What is Cabotib 40 Tablet used for?

Cabotib 40 Tablet is used to treat certain cancers, such as kidney cancer (advanced renal cell carcinoma), liver cancer after sorafenib, and thyroid cancer that has spread and no longer responds to radioactive iodine. In some cases, a doctor can also use this medicine for some neuroendocrine tumors (pancreas and extra‑pancreatic) after other treatments.

Who should not take Cabotib 40 Tablet?

There are no absolute “do not use” conditions known with Cabotib 40 Tablet, but people with a recent serious bleed (hemorrhage) must not start it, and your doctor may avoid it in severe liver disease (Child‑Pugh C) because it has not been studied and can raise risks.

During Cabotib 40 Tablet treatment, what warning signs mean I should get urgent help?

During Cabotib 40 Tablet treatment, call your doctor immediately if you experience coughing/vomiting blood, or black stools (bleeding). Sudden severe stomach pain or fever (perforation), chest pain or sudden shortness of breath (clot/heart attack), severe headache or confusion (hypertensive crisis/RPLS), severe or nonstop diarrhea, yellow eyes/skin (liver injury), sudden leg swelling, or new/worse jaw pain or mouth sores that will not heal (jaw bone problem).

Will Cabotib 40 Tablet affect surgery or dental work?

Yes. Your doctor may stop Cabotib 40 Tablet at least 3 weeks before planned surgery (including dental surgery) and will not restart for at least 2 weeks after major surgery and until wounds are well‑healed, because of bleeding and poor wound healing risks.

What health conditions need extra care during Cabotib 40 Tablet treatment?

During Cabotib 40 Tablet treatment, tell your doctor if you have high blood pressure (hypertension), bleeding risks, stomach or bowel disease, recent surgery, liver disease, kidney issues, jaw/dental problems, thyroid disease, or a history of blood clots or heart attack, because you may need monitoring, dose changes, or to avoid treatment in some cases.

Can Cabotib 40 Tablet harm a baby or affect fertility?

Yes. Cabotib 40 Tablet can harm an unborn baby. Females who can become pregnant should use effective birth control during treatment and for 4 months after the last dose. Breastfeeding should not happen during treatment and for 4 months after the last dose. It may reduce fertility in males and females, making it harder to have a baby.

What serious side effects of Cabotib 40 Tablet happen most often?

The common serious side effects of Cabotib 40 Tablet include severe diarrhea, severe high blood pressure, hand‑foot skin reaction (painful redness/blisters on palms/soles), liver test increases (especially with nivolumab, lowercase as drug component), blood clots, and bleeding. Your team may pause treatment and restart at a lower dose, or stop permanently if severe.

Fact Box

Chemical Class

Diarylethers

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine Kinase Inhibitors (TKIs)

Related lab tests

Alpha-fetoprotein (AFP) L3 Fraction

Complete Blood Count

Thyroid Profile Free

References

Cabozantinib [Prescribing Information]. Alameda, CA: Exelixis, Inc.; 2025. [Accessed 02 Jan. 2026]. Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Glenmark Pharmaceuticals Ltd
Address: Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Cabotib 40 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Cabotib 40 Tablet

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General Information

Contains

Marketer

Product introduction

Uses of Cabotib Tablet

Benefits of Cabotib Tablet

Side effects of Cabotib Tablet

How to use Cabotib Tablet

How Cabotib Tablet works

All substitutes for Cabotib 40 Tablet

Cabolong 40mg Tablet

Caboneal 40mg Tablet

Lupizotib 40mg Tablet

Cazanat 40 Tablet

Cabdual 40mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Hydroxychloroquine (Oral Route)

Phenindione (Oral Route)

Warfarin (Oral Route)

Sevoflurane (Oral Route)

Lenvatinib (Oral Route)

Frequently asked questions

What is Cabotib 40 Tablet used for?

Who should not take Cabotib 40 Tablet?

During Cabotib 40 Tablet treatment, what warning signs mean I should get urgent help?

Will Cabotib 40 Tablet affect surgery or dental work?

What health conditions need extra care during Cabotib 40 Tablet treatment?

Can Cabotib 40 Tablet harm a baby or affect fertility?

What serious side effects of Cabotib 40 Tablet happen most often?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Alpha-fetoprotein (AFP) L3 Fraction

Complete Blood Count

Thyroid Profile Free

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests