Bucelon 2 Tablet is used in the treatment of some cancers of blood like chronic myeloid leukaemia. It is used in combination with other cancer medicines during hematopoietic progenitor cell transplantation (HPCT). It may also be used to treat some other types of cancer.

Bucelon 2 Tablet can be taken with or without food, but better to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include decreased blood cells (red cells, white cells, and platelets), nausea, vomiting, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Bucelon Tablet

Blood cancer (Chronic myeloid leukaemia)

Benefits of Bucelon Tablet

In Blood cancer (Chronic myeloid leukaemia)

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Bucelon 2 Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Bucelon Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Bucelon

Decreased blood cells (red cells, white cells, and platelets)
Abdominal pain
Anxiety
Nausea
Vomiting
Loss of appetite
Decreased magnesium level in blood
Decreased potassium level in blood
Diarrhea
Fever
Headache
Increased glucose level in blood
Insomnia (difficulty in sleeping)
Stomatitis (Inflammation of the mouth)

How to use Bucelon Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bucelon 2 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Bucelon Tablet works

Bucelon 2 Tablet is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Bucelon 2 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Bucelon 2 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Bucelon 2 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Bucelon 2 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

SAFE IF PRESCRIBED

Bucelon 2 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Bucelon 2 Tablet may not be needed in these patients. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Bucelon 2 Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Bucelon Tablet?

If you miss a dose of Bucelon 2 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Bucelon 2 Tablet

₹3.3/Tablet

Nisulfan 2mg Tablet

Samarth Life Sciences Pvt Ltd

₹8.33/tablet

152% costlier

Busulfano 2mg Tablet

Glaxo SmithKline Pharmaceuticals Ltd

₹1.61/tablet

51% cheaper

Mysulfan 2mg Tablet

Chandra Bhagat Pharma Pvt Ltd

₹5.75/tablet

74% costlier

Glosulfan 2mg Tablet

Globela Pharma Pvt Ltd

₹4.36/tablet

32% costlier

Busulmax 2mg Tablet

GLS Pharma Ltd.

₹6.16/tablet

87% costlier

View all substitutes

Quick tips

Take it at a same time every day, either with food or without food.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood.
Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat.

Fact Box

Chemical Class

Organosulfonic Acid Esters Derivative {Alkylating Agent

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

Interaction with drugs

Taking Bucelon with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Sargramostim (Injection Route) Severe

Do not consume Busulfan from 1 day before until 1 day after taking Sargramostim. Please consult your doctor. Concurrent use may cause a decrease in the ability of the bone marrow ... More

Lenograstim (Injection Route) Severe

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy. Concurrent use may cause a decrease in the ability of the bone marrow to pr... More

Filgrastim (Injection Route) Severe

Do not consume Filgrastim from 24 hours before or 24 hours after taking Busulfan. Please consult with your doctor. Busulfan may reduce the efficacy of Filgrastim.

Pegfilgrastim (Injection Route) Severe

Do not consume Busulfan from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor. Concurrent use may cause a decrease in the ability of the bone ma... More

Molgramostim (Injection Route) Severe

Do not consume Busulfan from 1 day before until 1 day after taking Molgramostim. Please consult your doctor. Concurrent use may cause a decrease in the ability of the bone marrow ... More

View all drug interactions

Patient concerns

She is suffering from chronic myeloid leukemia

Dr. Deepak Kumar Soni

Ayurveda

Hi Kindly consult to Ayurvedic doctor at your local city area , face to face consult is needed.

Mh mother have blood cancer .recently she got her first induction chemotherapy.in CBC test Immature myeloid cells 18 percent what are indicate.is it serious .is it shown presence of cancer in blood old tell me

Dr. Ila Jain Khandelwal

Pathology

Dear Mam Greetings from 1mg, The reports shows low hemoglobin and platelet count which can be due to chemotherapy.

I want to know the symptoms of cancer as I am a smoker

Dr. Vijay Sharnangat

Medical Oncology and Hematology

Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time.

Does Bucelon 2 Tablet cause hair loss?

Yes, Bucelon 2 Tablet can cause hair loss.

Is Bucelon 2 Tablet a vesicant?

Yes. Bucelon 2 Tablet is a vesicant (irritant).

Related lab tests

Bcr-Abl Gene Translocation (Qualitative)

Bcr-Abl Gene Translocation (Quantitative)

Complete Blood Count

Peripheral Smear Examination

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1685-86.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 171-72.
Busulfan. Ireland: Aspen Pharma Trading Limited; 13 Jan. 1986 [revised Sep. 2017]. [Accessed 26 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Busulfan. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from: