Atrest 25 Tablet
Prescription Required
Product introduction
Atrest 25 Tablet is used to treat chorea (which is a movement disorder characterized by involuntary, jerky movements) associated with Huntington's disease. It reduces movements and improves function. This makes it easier for the person to move and function better.
Atrest 25 Tablet should be taken with or without food. However, it is advised to take it at the same time each day, as this helps maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor. This medication must not be stopped suddenly without talking to your doctor, as it may worsen your symptoms.
Some common side effects of this medicine include nausea, insomnia (difficulty sleeping), anxiety, fatigue, akathisia (restlessness and inability to stay still), and depression. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.
Stop taking this medicine immediately if you have a fever, stiff muscles, confusion, or seizures (signs of neuroleptic malignant syndrome). Let your doctor know if you have any medical conditions. Let your doctor also know about all the medications you are taking, as some medicines may interact with Atrest 25 Tablet. Pregnant or breastfeeding women should consult their doctor before taking Atrest 25 Tablet to ensure safety.
Uses of Atrest Tablet
Benefits of Atrest Tablet
In Treatment of Huntington's disease
Atrest 25 Tablet helps reduce involuntary, jerky movements caused by Huntington’s disease, making everyday activities easier and more manageable. Improving muscle control and coordination improves mobility and stability, allowing for better movement and independence. This leads to a better quality of life, helping individuals regain more control over their bodies and daily functions.
Side effects of Atrest Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Atrest
- Nausea
- Insomnia (difficulty in sleeping)
- Anxiety
- Fatigue
- Sleepiness
- Akathisia (inability to stay still)
- Depression
- Agitation
How to use Atrest Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Atrest 25 Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Atrest Tablet works
Atrest 25 Tablet works by reducing extra dopamine levels in the brain. Dopamine is a chemical that controls movement, and too much of it can cause involuntary, jerky movements seen in Huntington’s disease. Balancing dopamine helps calm these movements, making it easier to control body motions and perform daily activities.
Safety advice
Alcohol
UNSAFE
Atrest 25 Tablet may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Atrest 25 Tablet during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Atrest 25 Tablet during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Atrest 25 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Atrest 25 Tablet in patients with kidney disease. Please consult your doctor.
However, caution is advised in these patients.
However, caution is advised in these patients.
Liver
UNSAFE
Atrest 25 Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
What if you forget to take Atrest Tablet?
If you miss a dose of Atrest 25 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
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Quick tips
- Be cautious while driving or doing anything that requires concentration, as Atrest 25 Tablet can cause dizziness and sleepiness.
- Inform your doctor if you experience high fever, sweating, muscle stiffness, and faster breathing. These may be due to a rare side effect known as neuroleptic malignant syndrome.
- Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
- Do not stop taking Atrest 25 Tablet without talking to your doctor first, as it may cause worsening of symptoms.
Fact Box
Chemical Class
Tetrahydroisoquinoline Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors
Interaction with drugs
Taking Atrest with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Do not consume Voriconazole with Tetrabenazine.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Fluconazole with Tetrabenazine.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Voriconazole with Tetrabenazine.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Efavirenz with Tetrabenazine.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Tetrabenazine with Amiodarone.
Concomitant use may affect heart rhythm and may be fatal.
Patient concerns
User feedback
Patients taking Atrest 25 Tablet
Twice A Day
52%
Once A Day
28%
Thrice A Day
20%
What are you using Atrest Tablet for?
Huntington's *
75%
Others
25%
*Huntington's disease
How much was the improvement?
Excellent
40%
Poor
33%
Average
27%
What were the side-effects while using Atrest 25 Tablet?
No Side Effec*
67%
Nausea
33%
*No Side Effect
How do you take Atrest Tablet?
With food
100%
Please rate Atrest 25 Tablet on price
Expensive
83%
Average
17%
FAQs
Is Atrest 25 Tablet an antipsychotic?
Atrest 25 Tablet is not an antipsychotic. It belongs to the vesicular monoamine transporter 2 (VMAT2) inhibitor class of medicines. It works by changing the activity of some natural substances in the brain that affect muscles and nerves.
What is the most important information that I should know about Atrest 25 Tablet?
Atrest 25 Tablet may increase the risk of depression or suicidal thoughts in patients with Huntington’s disease. Huntington’s disease is an inherited disease that causes the progressive breakdown of nerve cells in the brain. Therefore, you should not take Atrest 25 Tablet if you have Huntington’s disease along with depression.
What should I avoid while taking Atrest 25 Tablet?
Sleepiness is a common side effect of Atrest 25 Tablet. Therefore, you should avoid driving or operating heavy machinery if you feel sleepy while taking Atrest 25 Tablet.
Can I stop taking Atrest 25 Tablet on my own?
No, you should not stop taking Atrest 25 Tablet suddenly, without talking to your doctor. Sudden discontinuation of the medicine may cause neuroleptic malignant syndrome. This can be characterized by high fever, stiff muscles, confusion, hallucinations, increased sweating, and very fast or uneven heartbeat. Hence, to avoid such side effects, your doctor will gradually reduce your dose.
Can I take alcohol while on Atrest 25 Tablet?
You should avoid alcohol since it may add to the sleepiness caused by Atrest 25 Tablet. Similarly, you should avoid taking medicines that cause sleepiness. If you are not sure about the effects of the medicine, consult with your doctor.
Does Atrest 25 Tablet affect blood pressure?
Yes, Atrest 25 Tablet may affect blood pressure. In some patients, it may lower blood pressure. Along with that, one may experience dizziness, lightheadedness, and fainting while getting up quickly from a lying position (orthostatic hypotension). To avoid this problem, get out of bed slowly and rest your feet on the floor for a few minutes before standing up.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Aminoff MJ. Pharmacologic Management of Parkinsonism & Other Movement Disorders. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 480.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1337-38.
- Tetrabenazine [Prescribing Information]. Washington, DC: Prestwick Pharmaceutical; 2008. [Accessed 19 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
- Tetrabenazine [Product Label]. Centuar Pharma. [Accessed 07 Aug. 2023]. (online) Available from:
- Tetrabenazine [Prescribing Information]. Princeton, NJ: Dr. Reddy’s Laboratories Inc.; 2020. [Accessed 13 Mar. 2025] (online) Available from:
Marketer details
Name: Centaur Pharmaceuticals Pvt Ltd
Address: CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.
Country of origin: India
Expires on or after: February, 2026
A licensed vendor partner from your nearest location will deliver Atrest 25 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: February, 2026
A licensed vendor partner from your nearest location will deliver Atrest 25 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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