Apnicaf Injection

Caffeine (10mg)

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Apnicaf Injection is a prescription medicine used in the treatment of apnea (a disorder in which breathing repeatedly stops and starts) of prematurity. It facilitates normal breathing and reduces interrupted breathing in premature newborns.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 29 Jun 2026 | 05:05 PM (IST)

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Apnicaf 10mg Injection

vial of 1 ml Injection

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~~₹263.02~~

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General Information

Contains

Caffeine (10mg)

Marketer

Abbott

Storage

Store below 30°C

The content is shown in English

Product introduction

Apnicaf Injection is given under the supervision of healthcare professionals. Remember, if you are breastfeeding while your infant is treated with this medicine, then do not drink coffee or take any other high caffeine product as this passes into breast milk.

Some common side effects of this medicine include mild delirium, insomnia, frequent urge to urinate, dehydration, tachycardia, and fever. Consult your doctor if these do not go away or persist for a longer duration. They may be able to suggest ways to prevent or reduce the side effects.

Uses of Apnicaf Injection

Apnea of prematurity

Benefits of Apnicaf Injection

Apnea of prematurity
In a premature baby, the part of the brain that controls breathing is not mature enough for nonstop breathing. This causes large bursts of breath followed by periods of shallow breathing or stopped breathing. This is called apnea or breathing trouble of prematurity. Apnicaf Injection helps to stimulate those areas of the brain that control breathing and normalise it. It is given as an injection by a doctor or nurse.

Side effects of Apnicaf Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Apnicaf

Delirium (acute confusional state)
Dehydration
Fever
Insomnia (difficulty in sleeping)
Frequent urge to urinate

How to use Apnicaf Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Apnicaf Injection works

Apnicaf Injection is a stimulant. It works by blocking the action of certain natural substances (adenosine and phosphodiesterase) leading to stimulation of the brain and respiratory system in premature newborns. This reduces the number of episodes of interrupted breathing and helps the newborns breathe on their own.

Quick tips

Apnicaf Injection helps in the treatment of interrupted breathing in premature babies.
It is given as an injection (drip) by your doctor or nurse.
If you are breast-feeding while your infant is treated with Apnicaf Injection, do not drink coffee or take any other high caffeine product as caffeine passes into breast milk.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Apnicaf Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Apnicaf Injection is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Apnicaf Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

NOT RELEVANT

Not relevant, as Apnicaf Injection is intended for use in hospitalized patients.

Kidney

CAUTION

Apnicaf Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Apnicaf Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Apnicaf with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Axitinib (Oral Route)

If concurrent use is essential, watch out for symptoms such as acute confusional state, difficulty in sleeping, frequent urge to urinate or fever and consult your doctor if you experience them. They may adjust the doses as per the observations. Axitinib may raise blood levels of Caffeine.

Moderate

Amoxapine (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required.

Moderate

Paroxetine (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required.

Moderate

Tranylcypromine (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Caffeine may reduce efficacy of Tranylcypromine.

Moderate

Phenobarbitone (Oral Route)

It is recommended to avoid Caffeine after taking Phenobarbitone, especially at bedtime. Caffeine may reduce the efficacy of Phenobarbitone.

Frequently asked questions

What is Apnicaf Injection and why is it used in newborns?

Apnicaf Injection is a medicine given to premature babies who have apnea of prematurity. This condition causes infants to stop breathing for short periods because their breathing system is not fully developed. Apnicaf Injection helps stimulate the baby’s brain and lungs to improve breathing.

How does Apnicaf Injection work in premature babies?

Apnicaf Injection works by stimulating the central nervous system and the baby’s breathing center. It makes the brain more responsive to carbon dioxide and helps reduce episodes where the baby stops breathing. It also improves muscle tone and decreases fatigue of the diaphragm, the muscle that controls breathing.

Who should not receive Apnicaf Injection?

Apnicaf Injection should not be given to infants who are allergic or hypersensitive to caffeine, or any of the ingredients in the medicine. If a baby has shown any allergic reaction to caffeine in the past, this medicine should be avoided.

What serious risks are linked with Apnicaf Injection in newborns?

One of the most serious risks linked to Apnicaf Injection is necrotizing enterocolitis (a life-threatening bowel condition) that has been reported in premature babies during clinical studies. Because of this, babies receiving this medicine must be closely monitored for abdominal bloating, vomiting, bloody stools, or sudden changes in energy levels.

Can Apnicaf Injection be used for long-term treatment?

No, Apnicaf Injection is meant only for short-term treatment of apnea of prematurity, typically for ten to twelve days. Its safety and effectiveness for long-term use, or for other conditions such as sudden infant death syndrome (SIDS), have not been proven.

What precautions should doctors take before giving Apnicaf Injection?

Before starting Apnicaf Injection treatment, doctors should rule out other possible causes of apnea, such as infections, anemia, or lung disease. They may also need to check caffeine levels in babies who were previously given theophylline, or whose mothers consumed caffeine before delivery, since these can affect blood caffeine levels.

What should caregivers watch for while their baby is on Apnicaf Injection?

While the baby is on Apnicaf Injection treatment, parents or caregivers should immediately contact the doctor if the baby develops a swollen belly, vomiting, bloody stools, unusual sleepiness, or seems unwell. These may be signs of serious complications such as necrotizing enterocolitis.

Fact Box

Chemical Class

Xanthine derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Adenosine receptor (A1 & A2) antagonist

References

O’Brien CP. Drug Addiction. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 663.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 179-83.
Tulane University: School of Medicine. Caffeine. [Accessed 29 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Caffeine. [Updated 2019 Jun 30]. [Accessed 20 Feb. 2020] (online) Available from:

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Increased production of urine

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India

Vendor Details

Country of origin: India

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Apnicaf Injection

Apnicaf Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Apnicaf Injection

Benefits of Apnicaf Injection

Side effects of Apnicaf Injection

How to use Apnicaf Injection

How Apnicaf Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Axitinib (Oral Route)

Amoxapine (Oral Route)

Paroxetine (Oral Route)

Tranylcypromine (Oral Route)

Phenobarbitone (Oral Route)

Frequently asked questions

What is Apnicaf Injection and why is it used in newborns?

How does Apnicaf Injection work in premature babies?

Who should not receive Apnicaf Injection?

What serious risks are linked with Apnicaf Injection in newborns?

Can Apnicaf Injection be used for long-term treatment?

What precautions should doctors take before giving Apnicaf Injection?

What should caregivers watch for while their baby is on Apnicaf Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

What are you using Apnicaf Injection for?

How much was the improvement?

What were the side-effects while using Apnicaf Injection?

How do you take Apnicaf Injection?

Please rate Apnicaf Injection on price

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Disclaimer

Marketer details

Vendor Details

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