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Afdethro Cream

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 25 Nov 2025 | 03:05 PM (IST)
Afdethro Cream is an antibiotic used to treat acne (pimples) and some bacterial skin infections. It helps to reduce the number of pimples. This medicine stops the bacteria from growing, which helps to resolve your symptoms.
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Afdethro Cream image
Afdethro Cream image

Product introduction

Afdethro Cream is meant for external use only. It should be applied only to the affected area of the skin as per the dosage and schedule prescribed by your doctor. In order to get the most benefit, apply it regularly and preferably at a fixed time each day. Do not use larger amounts or apply it more often or for a longer duration than directed. This will only increase the risk of side effects. You may have to use it for a long time before your acne starts to improve. Be patient and keep using it every day.

This medicine is generally safe to use with minimal side effects such as peeling of the skin, redness, dry skin, irritation, itching, stinging, and burning sensation. Consult your doctor if these persist or if your condition does not improve.

Avoid any contact with your eyes, nose, or mouth. Rinse it off with water if you accidentally get the medicine in these areas. Before using it, inform your doctor if you have any previous history of allergy to it or any other medicine. Pregnant or breastfeeding women should consult their doctor before using it.

Uses of Afdethro Cream

Benefits of Afdethro Cream

Treatment of Bacterial infections
Afdethro Cream is an antibiotic medicine which can be used to treat many different infections caused by bacteria. These include infections of the ear, nose, throat, lungs and skin. It stops the growth of the bacteria causing the infection and clears the infection. Take it for as long as prescribed by the doctor and avoid skipping doses. This will make sure that all bacteria are killed and they do not become resistant.
Acne
Afdethro Cream treats acne, commonly called pimples. It kills the acne-causing bacteria and prevents spots or pimples from appearing. It usually takes a few weeks to have a noticeable effect so keep using it even if it appears not to be working. Sometimes acne may get worse before it gets better, however, with proper use, your skin will get clearer. The earlier you start using it, the less likely you are to get scars. This medicine will help improve your mood and uplift your confidence as your skin becomes acne free. It should not be used if you have eczema or sunburned skin.

Side effects of Afdethro Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Afdethro
  • Dry skin
  • Burning sensation
  • Itching
  • Skin peeling
  • Skin irritation

How to use Afdethro Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Afdethro Cream works

Afdethro Cream is an antibiotic which stops the growth of acne-causing bacteria on the skin. It does so by preventing synthesis of essential proteins required by these bacteria to carry out vital functions.

Quick tips

  • You have been prescribed Afdethro Cream for the treatment of severe acne.
  • You may have to use it for a long time before your acne starts to improve. Be patient and keep using it every day.
  • Apply it as a thin layer on to clean, dry, unbroken skin affected by acne.
  • Wash your skin with a mild cleanser and pat it dry before applying Afdethro Cream.
  • It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
  • Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas.
  • If you think the area of skin you are treating has become more irritated and infected, you should stop using Afdethro Cream and consult your doctor.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Afdethro Cream is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Interaction with drugs

Taking Afdethro with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Estradiol (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Erythromycin may raise blood levels of Estradiol.
Moderate

Estrogen (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Erythromycin may raise blood levels of Estrogen.
Moderate

Estradiol (Injection Route)

Talk to your doctor if you notice any unusual symptoms. Erythromycin may raise blood levels of Estradiol.
Moderate

Fluvastatin (Oral Route)

Talk to your doctor if you experience muscle pain, tenderness, or weakness during the simultaneous use of these medicines.
Moderate

Estradiol (Skin Route)

Talk to your doctor if you notice any unusual symptoms. Erythromycin may raise blood levels of Estradiol.

Frequently asked questions

Afdethro Cream should be applied twice daily. It should be applied to a dry, clean face to lessen the possibility of irritation. Spread it gently and uniformly in a thin layer but you need not rub it in.
Afdethro Cream is used for treatment of acne vulgaris also known as pimples or spots. It is used to reduce the growth of bacteria which cause acne. It can also be used to treat skin infections.
Afdethro Cream should be applied cautiously. It should not come into contact with the eyes, lips, or the lining of the mouth or nose. Do not apply to broken skin. If accidental contact occurs, rinse thoroughly with water. Be careful not to use cosmetic products containing alcohol, irritant, or medicated soaps, as these may cause irritation or drying effects.
Successful treatment of acne may take several weeks or even months. The normal treatment time is 10 to 12 weeks. Consult your doctor, if you do not see improvement at the end of the prescribed course of treatment.
If you have already used Afdethro Cream, antibiotics of the same class (macrolides), clindamycin and lincomycin may also not work. This could be because of drug resistance. In this, the bacteria gets modified in your body and medicines may not be able to treat the new modified form.
Store it in a cool dry place below 25 degrees centigrade. Some of the preparations may contain alcohol, which are flammable, and therefore should be kept away from high temperatures.
Try not to forget to use Afdethro Cream, as missing an application will slow down the healing process. However, if you have missed an application, use Afdethro Cream as soon as you remember, but a gap of about three hours is required before you use it again.

Fact Box

Chemical Class

Macrolides

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Action Class

Macrolides

References

  1. Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1327-28.
  2. Chambers HF, Deck DH. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidiones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 799-800.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 491-94.
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User feedback

Bacterial infections
100%
Excellent
67%
Average
33%
No Side Effect
100%
With food
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Anglo-French Drugs & Industries Ltd
Address: No. 41, 3rd Cross, 5th Block, Rajajinagar, Bengaluru – 560 010, Karnataka , India

Vendor Details

Country of origin: India
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