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Adiff Gel

Adapalene (0.1% w/w)

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Adiff Gel is a medication used in the treatment of mild to moderate acne (pimples) with blackheads/whiteheads and small, inflamed spots on the face, chest, or back. It works by reducing excessive oil production in the skin, thereby reducing inflammation or cleaning the blocked pores.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 12 Mar 2026 | 12:44 PM (IST)

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15 gm Gel

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Adiff Gel

tube of 15 gm Gel

₹10.07 per gm

₹178

~~₹204.5~~

13% off

₹151

order for

₹1200

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by Ipca Laboratories Ltd

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Derpalin 0.1% Gel

tube of 15 gm Gel

₹5.19 per gm

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~~₹112.5~~

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order for

₹1200

Get by Mon, 25 May

by Leeford Healthcare Ltd

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General Information

Contains

Adapalene (0.1% w/w)

Marketer

Ipca Laboratories Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Use Adiff Gel as prescribed by your doctor in the dose and duration specified. Do not use a larger amount or for longer than the prescribed duration. While on treatment, avoid unnecessary sun exposure and cover the treated areas with clothing or use a sunscreen before stepping out in the sun.

Common side effects of Adiff Gel include dry skin, skin irritation, burning sensation, or redness. If any of these side effects persist or worsen, consult your doctor. They may be able to guide you on how to manage or treat the side effects.

Adiff Gel should not be used during pregnancy, as it may cause harmful effects to the developing baby. Consult your doctor if you are pregnant or planning to get pregnant. This medicine should not be used in children below 12 years of age. Avoid applying it to broken, sunburnt, or eczema skin.

Uses of Adiff Gel

Treatment of Acne

Benefits of Adiff Gel

Treatment of Acne
Adiff Gel helps treat clear acne (pimples) and prevent new lesions. It works by reducing the production of excessive oil in the skin. It usually takes a few weeks to have a noticeable effect. Keep using it even if it appears not to be working. Sometimes acne may get worse before it gets better; however, with proper use, your skin will get clearer.

Side effects of Adiff Gel

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Adiff

Erythema (skin redness)
Dry skin
Skin burn

How to use Adiff Gel

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.

How Adiff Gel works

Adiff Gel is a retinoid-like medicine that works inside skin cells to normalise how they grow and shed, helping prevent blocked pores (microcomedones) and reducing inflammation in acne.

All substitutes for Adiff Gel

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Avoid getting it in your eyes or mouth. If this happens, rinse with water immediately.
Avoid getting any cosmetic procedures done without consulting your doctor first.
Do not use on cuts, abrasions, sunburnt, or eczema skin.
This medicine is not recommended for children under 12 years.
It is not suitable for severe acne involving large body areas.
If severe redness/peeling occurs, reduce frequency or stop and consult your doctor.

Safety advice

Alcohol

No interaction found/established

Pregnancy

UNSAFE

Adiff Gel is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.
To avoid any contact with your baby, do not apply it to the chest area.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

Frequently asked questions

Is Adiff Gel safe to be used in pregnancy?

No, Adiff Gel should not be used during pregnancy. If you become pregnant during the treatment, discontinue the medicine immediately and consult your doctor. Do not plan a pregnancy while using Adiff Gel.

Is it safe to undergo cosmetic procedures while using Adiff Gel?

It is advisable not to undergo cosmetic procedures while using Adiff Gel. Cosmetic products with an abrasive, drying, or peeling action may cause an increased irritant effect. Consult your doctor if you are not sure.

Is it normal to have a burning sensation after applying Adiff Gel?

Yes, it is common to experience a burning sensation on application of Adiff Gel. You may also experience redness, drying, and scaling during the first 4 weeks of treatment, which usually lessen with continued use of Adiff Gel. Inform your doctor if the side effects bother you or do not improve.

How long does it take to see results from Adiff Gel?

You may start noticing an improvement after two weeks of therapy, but a minimum of eight weeks is required to notice consistent beneficial effects.

Can I use moisturiser after Adiff Gel?

Moisturizers may be used, if necessary; however, products containing alpha hydroxy or glycolic acids should be avoided.

What precautions do I need to follow while using Adiff Gel?

You need to be cautious while applying Adiff Gel. Avoid contact with the eyes, lips, nose, and inside of the mouth. This medication should not be applied to cuts, abrasions, inflamed or reddened skin, or sunburned skin. Wax epilation should not be performed on treated skin, as it may cause skin erosions.

Fact Box

Chemical Class

Retinoids

Habit Forming

Therapeutic Class

DERMA

Action Class

Retinoids- Third generation

References

Robertson DB, Maibach HI. Dermatologic Pharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1056.
Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1810.
Sardana K, Madan A. How to Treat Acne. Sardana K, editor. In: Clinical Approach to Acne Vulgaris. 1st ed. New Delhi: CBS Publishers & Distributors Pvt. Ltd.; 2015. pp. 36-37.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 24-25.
Adapalene [EMC SmPC. Watford, Hertfordshire: Galderma (U.K) Ltd.; 2022. [Accessed 16 Jan. 2026] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 03 Apr. 2019] (online) Available from:
Adapalene [Prescribing Information]. Baie d’Urfé, QC: G Production Inc.; 2012. [Accessed 20 Feb. 2024] (online) Available from:
Adapalene [Summary of Product Characteristics]. Mumbai, India: Glenmark Pharmaceuticals Limited; 2024.

User feedback

Patients taking Adiff Gel

Once A Day

89%

Alternate Day

Four Times A Day

Twice A Day

Thrice A week

Thrice A Day

Twice A Week

What are you using Adiff Gel for?

Acne

92%

Others

How much was the improvement?

Average

36%

Poor

32%

Excellent

32%

What were the side-effects while using Adiff Gel?

Itching

23%

Skin peeling

23%

Dry skin

23%

No Side Effect

15%

Skin burn

15%

How do you take Adiff Gel?

With or without food

53%

With food

47%

Please rate Adiff Gel on price

Average

58%

Not Expensive

29%

Expensive

12%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ipca Laboratories Ltd
Address: 142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Adiff Gel. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Adiff Gel

Cash on delivery

Free Return

Expiry after

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Adiff Gel

Benefits of Adiff Gel

Side effects of Adiff Gel

How to use Adiff Gel

How Adiff Gel works

All substitutes for Adiff Gel

Adaferin Gel

Deriva MS Aqueous Gel

Apgel

Adlene 0.1% Gel

Acnerem Gel

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

Is Adiff Gel safe to be used in pregnancy?

Is it safe to undergo cosmetic procedures while using Adiff Gel?

Is it normal to have a burning sensation after applying Adiff Gel?

How long does it take to see results from Adiff Gel?

Can I use moisturiser after Adiff Gel?

What precautions do I need to follow while using Adiff Gel?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Adiff Gel

What are you using Adiff Gel for?

How much was the improvement?

What were the side-effects while using Adiff Gel?

How do you take Adiff Gel?

Please rate Adiff Gel on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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