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MMST, MBBS
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MD (Pharmacology), MBBS
Last updated:
21 Feb 2020 | 12:19 PM (IST)
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Actitop 100mg Injection


Overview

Introduction

Actitop 100mg Injection is used to treat different cancers of lung, and testicles. It is also sometimes used to treat some other kinds of cancer in both men and women. It can be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy.

Actitop 100mg Injection is given as slow injection into veins under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effect of this medicine includes low blood platelets, vomiting, nausea, hair loss, and anemia (low number of red blood cells).  If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It is important to use effective contraception to avoid getting pregnant or fathering a child during treatment.

Before taking this medicine, let your doctor know if you have liver or kidney disease, or if have been on radiation therapy. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. Your doctor may check you for blood cells and liver functioning while taking this medicine.

Side effects of Actitop Injection

Common
  • Anemia (low number of red blood cells)
  • Decreased blood cells (red cells, white cells, and platelets)
  • Decreased white blood cell count
  • Diarrhea
  • Hair loss
  • Liver damage
  • Low blood platelets
  • Nausea
  • Rash
  • Stomatitis (Inflammation of the mouth)
  • Vomiting

How to use Actitop Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Actitop Injection works

Actitop 100mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Actitop 100mg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Actitop 100mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
UNSAFE
Actitop 100mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
SAFE
Actitop 100mg Injection does not usually affect your ability to drive.
Kidney
CAUTION
Actitop 100mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Actitop 100mg Injection may be needed. Please consult your doctor.
Use of Actitop 100mg Injection is not recommended in patients with end-stage kidney disease.
Liver
CAUTION
Actitop 100mg Injection should be used with caution in patients with liver disease. Dose adjustment of Actitop 100mg Injection may be needed. Please consult your doctor.
Use of Actitop 100mg Injection is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Actitop 100mg Injection
₹38.0/ml of Injection
Posid 100mg Injection
Cadila Pharmaceuticals Ltd
₹26.19/ml of Injection
save 31%
Oncosid 100mg Injection
United Biotech Pvt Ltd
₹37.4/ml of Injection
save 2%
₹38/ml of Injection
same price
Etolon 100mg Injection
Celon Laboratories Ltd
₹82/Injection
116% costlier
Bioposide 100mg Injection
Biochem Pharmaceutical Industries
₹96/Injection
153% costlier

Quick Tips

  • Avoid contact with people with cold or other infections as etoposide treatment may lower your immunity.
  • Seek immediate medical attention if you notice any unusual bleeding, bruising, blood in stools, or dark, tarry stools.
  • You will be regularly evaluated with lab tests, including complete blood cell counts to monitor your progress or to check for side effects.
  • Do not drive or operate machinery during etoposide treatment as it may cause dizziness.
  • Do not consume this drug if you are allergic to etoposide or any of its ingredients.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Interaction with Drugs

Taking Actitop with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Milorgen, Fosphen, Fosentin
SERIOUS
Brand(s): Shinosun, Epikon, Sonal
SERIOUS
Brand(s): Stoin, Marantin, Notian
SERIOUS
Brand(s): Imudrops
SERIOUS

Patient Concerns

arrow
What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma
Dr. Vijay Sharnangat
Medical Oncology and Hematology
This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer.
I seem to have lung cancer , becoz all the symptoms are same as lung cancer. I test my blood, they suggests me that it is highly probable to lung cancer. Sir what can i do now. This is in preliminary stage
Dr. Sanjay Singh Rai
Medical Oncology and Hematology
Do you think that lung cancer is diagnosed from blood
arrow
Do you have any questions related to Actitop 100mg Injection ?

FAQs

Q. Is Actitop a FDA approved vesicant/irritant?

Yes, Actitop is a FDA approved vesicant/irritant

Q. Is Actitop dialyzable?

No, Actitop is not dialyzable

Q. Does Actitop cause leukaemia?

Yes, Actitop may cause leukaemia. Please follow your doctor's advice regarding its use.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1715-16.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 520-21.
  3. Etoposide. Barnstaple, Devon: Accord-UK Ltd.; Accord-UK Ltd.; 2014 [revised 6 Feb. 2018]. [Accessed 23 Jan. 2019] (online) Available from:External Link
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Etoposide. [Updated 2019 Jun 3]. [Accessed 18 Feb. 2020] (online) Available from:External Link
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
KHANDELWAL LABORATORIES PVT. LTD, 79/87 D.LADPATH, MUMBAI 400 033, INDIA
A licensed vendor partner from your nearest location will deliver Actitop 100mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Best Price
₹152
MRP190  Get 20% OFF
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5 ml in 1 vial
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