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Last updated on:
08 Nov 2019 | 08:00 PM (IST)
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Actibile 150 Tablet


Overview

Introduction of Actibile Tablet

Actibile 150 Tablet is a medicine used to dissolve certain types of gallstones, to prevent them from forming and to treat a type of liver disease called primary biliary cirrhosis. It is a bile acid which helps break down cholesterol which has formed into stones in your gallbladder.

Actibile 150 Tablet should be taken after a meal with a glass of milk or water. The dose will depend on what you are being treated for and your body weight. It is best swallowed whole, but you may need to break them to get the correct dose. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear. Even if the gallstones completely dissolve, the treatment should still be continued for several weeks or months.

The most common side effects are diarrhoea, stomach upset or pain, feeling sick, dizziness, back pain or hair loss. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment.

Before taking this medicine, you should tell your doctor if you have an inflammation of the gallbladder or bile ducts, you get frequent cramp-like pain in your upper abdomen, you have been coughing up blood or you have gained weight rapidly. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking. Women who use this medicine for dissolving gallstones should stop using the birth control pill because the hormones in it can increase the production of gallstones. During treatment you may need ultrasound scans, or frequent blood tests to check your liver function.

Actibile Tablet side effects

Common
  • Nausea
  • Rash
  • Hair loss
  • Itching
  • Abdominal pain
  • Diarrhea

How to use Actibile Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Actibile 150 Tablet is to be taken with food.

How Actibile Tablet works

Actibile 150 Tablet is a hepatoprotective medication. It works by reducing the amount of cholesterol in the blood and helps dissolve gallbladder stones that are composed mainly of cholesterol. It also improves liver enzymes, protects liver cells from injury caused due to toxic bile acids, and improves liver function.

Actibile Tablet related warnings

Alcohol
UNSAFE
Actibile 150 Tablet may cause excessive drowsiness with alcohol
Pregnancy
SAFE IF PRESCRIBED
Actibile 150 Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Lactation
SAFE IF PRESCRIBED
Actibile 150 Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Actibile 150 Tablet does not usually affect your ability to drive.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Actibile 150 Tablet in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Actibile 150 Tablet in patients with liver disease. Please consult your doctor.

What if you miss a dose of Actibile Tablet?

If you miss a dose of Actibile 150 Tablet, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Actibile 150 Tablet
₹17.8/Tablet
Golbi 150 Tablet
Intas Pharmaceuticals Ltd
₹15.9/Tablet
save 11%
Udihep Tablet
Win-Medicare Pvt Ltd
₹23.8/Tablet
34% costlier
Sorbidiol 150 Tablet
Franco-Indian Pharmaceuticals Pvt Ltd
₹12.51/Tablet
save 30%
₹16.37/Tablet
save 8%
Ursokem 150 Tablet
Alkem Laboratories Ltd
₹16.6/Tablet
save 7%

Expert Advice

  • Take the medicine at bedtime regularly.
  • Eat a healthy diet, exercise regularly, and avoid alcohol intake.
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
  • Your doctor may monitor your liver function and bilirubin levels every month for three months after the start of therapy, and every six months thereafter.
  • Do not stop taking the medication without talking to your doctor.

Interaction with Drugs

Taking Actibile with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Imudrops, Neoral, Aurosporine
SERIOUS

Patient Concerns

Questions Related to Actibile

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sir, my father 61 years old man,have liver cirrhosis ,middle stage now using golbi 300mg tablet daily 2times , i want to know whether any problem if use low cost table substitute for golbi ??
Dr. Pushkar Mani
Diabetes Specialist
no there is no problem u can use low cost golbiuse LIVOKIND 300 mg ,its cheap and from good brand as well
Im pregnant with 8months and having itching in whole body. OT/PT is little higher. TakIm taking Actibile 300. Prescribed by My doctor. Do I need to consult gastro. This is my second issue. In 1st issue I had same problem. Ans as soon as i delivered baby this all disappeared.Please suggest what to do
Dr. Dharna Gupta
Gynaecologist and General Physician
Take actibile twice daily.use lactocalamine lotion.No need for gaatro consultYou can take tab cetrizine if itching is too muchFollow your OBS advice
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User Feedback


FAQs

Q. When should I take Actibile?

The suitable timing of taking this medicine might differ depending upon your condition. Your doctor might instruct you to take 2 to 3 doses per day and suggest to take the last dose at bedtime. Actibile should be taken with water and can be taken with food or after food. When prescribed for dissolving gallstones, it is usually suggested to be taken once daily at night. Ideally, it should be taken at a gap of 6 hours, for example at 8 am, 2 pm and 8 pm.

Q. Is Actibile safe?

Actibile is usually considered to be a safe and effective medicine. However, this medicine may have some common side effects, such as diarrhea. If diarrhea occurs, your doctor may reduce the dose and if it persists, your treatment may be discontinued. Additionally, using this medicine as a long term therapy may also affect your liver enzyme levels. To keep a check on this, your doctor will keep monitoring your liver enzyme levels regularly. Despite these minor side effects, this medicine is supposed to be a good alternative to surgery in some patients with gallstones.

Q. How does Actibile help the liver?

Actibile acts on the liver and gets concentrated in the bile secreted from the liver. This, as a result, suppresses the synthesis and secretion of cholesterol by the liver, thereby decreasing the cholesterol levels in bile. This medicine also acts by stopping the intestines from absorbing the bile salts and cholesterol. So, the reduced cholesterol saturation in the bile from the liver leads to gradual dissolving of cholesterol from gallstones, leading to a decrease in size and their eventual dissolution. It also reduces elevated liver enzyme levels by increasing the bile flow through the liver, hence protecting the liver cells.

Q. Does Actibile cause weight gain?

Yes, there is a chance of weight gain with Actibile, but it is not common. The use of Actibile can cause weight gain when prescribed in patients with liver disease associated with chronic stasis of bile in small bile ducts of liver, i.e. when bile cannot flow from the liver to the small intestine. Again, the chance of weight gain varies from person to person depending upon the disease, so consult your doctor if you experience weight gain.

Q. What should I avoid while taking Actibile?

While taking Actibile, avoid taking an antacid preparation or charcoal without consulting your doctor, as they decrease the effectiveness of Actibile. You should also avoid medicines like cholestyramine or colestipol as they affect the effectiveness of Actibile. So, ask your doctor about the time gap that should be maintained between Actibile and these medicines. Also, avoid taking oral contraceptives, estrogenic hormones and blood cholesterol-lowering agents such as clofibrate as they may increase the chances of developing gallstones and act opposite to the Actibile.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Ursodiol. Birmingham, Alabama: Axcan Pharma US, Inc.; 1997 [revised Nov. 2009]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  2. Ursodiol. Bridgewater, New Jersey: Aptalis Pharma US, Inc.; 1997 [revised Jun. 2013]. [Accessed 28 Mar. 2019] (online) Available from:External Link
  3. U.S. National Library of Medicine. Ursodiol. [Accessed 28 Mar. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
A licensed pharmacy from your nearest location will deliver Actibile 150 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your prescription and the availability of this medicine.
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