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Ursodex 300mg Tablet

Ursodeoxycholic Acid (300mg)

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Ursodex 300mg Tablet is used to treat cholesterol gallstones, primary biliary cirrhosis, primary sclerosing cholangitis, and liver disease associated with cystic fibrosis. It works by improving bile flow and breaking down excess cholesterol in bile, helping dissolve gallstones and protect the liver from damage.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 28 Apr 2026 | 03:52 PM (IST)

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General Information

Storage

Store below 30°C

The content is shown in English

Product introduction

Take Ursodex 300mg Tablet after a meal and with a glass of milk or water. The dose will depend on what you are being treated for and your health condition. Take it regularly to get maximum benefit, and keep taking it for as long as prescribed (several months or longer). Keep taking it even if your symptoms disappear.

The most common side effects of Ursodex 300mg Tablet are abdominal pain, diarrhea, hair loss, itching, nausea, and rash. Not everyone gets these side effects. If you are worried about them or they do not go away, let your doctor know. They may be able to suggest ways to manage them or prescribe an alternative medicine.

Before taking this medicine, tell your doctor if you have gallbladder or bile duct inflammation, frequent cramp-like pain in your upper abdomen, blood in your cough, or rapid weight gain. Using this medicine can increase or decrease the effects of other medicines, so tell your doctor about all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctor before using this medicine to make sure it is safe for them.

Uses of Ursodex Tablet

Treatment of Gallbladder stones
Treatment of Primary biliary cirrhosis

Benefits of Ursodex Tablet

Treatment of Gallbladder stones
Ursodex 300mg Tablet is a medicine that helps decreases the amount of cholesterol produced by your liver. It helps to break down cholesterol that has formed into “stones” in the gallbladder. It may take several months to completely dissolve the stone, so you need to take the medicine regularly and as long as the doctor has prescribed it for it to be effective. There might be other medicines and certain lifestyle changes that can reduce your cholesterol level and make gallstones less likely, consult with your doctor.

Treatment of Primary biliary cirrhosis
Primary biliary cirrhosis is a condition where bile ducts in the liver are damaged, leading to bile buildup. Ursodex 300mg Tablet helps improve bile flow and reduce liver inflammation. This slows disease progression and relieves symptoms such as fatigue and itching. Take it regularly to support long-term liver function.

Side effects of Ursodex Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Ursodex

Abdominal pain
Diarrhea
Nausea
Rash
Hair loss
Cough
Sinus inflammation
Upper respiratory tract infection
Urinary tract infection
Allergy
Chest pain
Dyspepsia
Abdominal discomfort
Headache
Itching
Back pain
Fatigue
Flatulence
Vomiting
Joint pain
Joint inflammation
Muscle pain
Insomnia (difficulty in sleeping)
Bronchitis (inflammation of the airways)

How to use Ursodex Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ursodex 300mg Tablet should be taken with or after food.

How Ursodex Tablet works

Ursodex 300mg Tablet is a hepatoprotective medication. It works by reducing the amount of cholesterol in the blood and helps dissolve gallbladder stones that are composed mainly of cholesterol. It also improves liver enzymes, protects liver cells from injury caused due to toxic bile acids, and improves liver function.

All substitutes for Ursodex 300mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Ursolid 300mg Tablet

by Leeford Healthcare Ltd

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Udiliv 300 Tablet

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Actibile 300 Tablet

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Ursetor 300 Tablet

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Quick tips

Take Ursodex 300mg Tablet after a meal with a glass of milk or water to help improve its absorption and reduce stomach upset.
Take Ursodex 300mg Tablet regularly at the same time each day, as it works gradually and may take time to show beneficial results.
Follow a healthy diet and exercise regularly, and avoid alcohol while taking Ursodex 300mg Tablet.
Avoid heavy or oily meals, as high-fat foods may worsen gallbladder or liver-related symptoms.
Diarrhea may occur as a side effect. Drink plenty of fluids, including oral rehydration solution (ORS), and inform your doctor if it persists or if you notice blood in your stools.
Your doctor may monitor liver function tests and bilirubin levels regularly, especially during the first few months of the treatment.
Seek medical advice promptly if you develop worsening jaundice, severe itching, dark urine, pale stools, persistent abdominal pain, or fever.
Do not stop taking Ursodex 300mg Tablet without consulting your doctor, as liver conditions often require monitored and continuous therapy.
Inform your doctor about all other medicines, herbal products, or supplements you are taking to avoid potential interactions.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Ursodex 300mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Ursodex 300mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Ursodex 300mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Ursodex 300mg Tablet does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Ursodex 300mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Ursodex 300mg Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.

Interaction with drugs

Taking Ursodex with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Magaldrate (Oral Route)

Ensure a gap of at least 2 hours between taking Ursodeoxycholic Acid and Magaldrate.

Moderate

Allylestrenol (Oral Route)

Careful consideration is advised when taking Ursodeoxycholic Acid with Allylestrenol. Your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Bezafibrate (Oral Route)

Do not consume Ursodeoxycholic Acid with Bezafibrate. If concurrent use is essential, your doctor may monitor the effects of Ursodeoxycholic Acid along with your overall treatment and adjust the doses as per the observations. Bezafibrate may reduce the efficacy of Ursodeoxycholic Acid.

Moderate

Cholestyramine (Oral Route)

Ensure a gap of at least 2 hours between taking Ursodeoxycholic Acid and Cholestyramine. Your doctor may monitor the effects of Ursodeoxycholic Acid. Cholestyramine may reduce blood levels of Ursodeoxycholic Acid.

Moderate

Colesevelam (Oral Route)

Ensure a gap of at least 4 hours between taking Ursodeoxycholic Acid and Colesevelam. Your doctor may monitor your treatment and adjust the doses as per the observations. Colesevelam may reduce blood levels of Ursodeoxycholic Acid.

Frequently asked questions

How should Ursodex 300mg Tablet be taken to ensure maximum absorption?

Ursodex 300mg Tablet should usually be taken with food or milk to help your body absorb it better and to reduce the chance of stomach upset. Taking it at the same time every day helps maintain a steady level of the medicine in your body. If you consume antacids that contain aluminum, they may interfere with how well Ursodex 300mg Tablet is absorbed. Taking it with a moderately high-fat meal (e.g., meals containing milk, curd, nuts, or oils) may further help in the absorption of ursodeoxycholic acid by promoting bile secretion.

What are the side effects of Ursodex 300mg Tablet?

Ursodex 300mg Tablet is generally well tolerated. Common side effects include diarrhea (most frequent), nausea, and abdominal discomfort. These are usually mild and temporary. Rarely, it may alter liver enzyme levels, especially with long-term use, so your doctor may recommend periodic monitoring.

What is Ursodex 300mg Tablet and what is it used for?

Ursodex 300mg Tablet contains ursodeoxycholic acid and is mainly used to dissolve certain cholesterol gallstones and to treat liver diseases such as primary biliary cholangitis. It works by lowering cholesterol levels in bile, improving bile flow, and protecting liver cells from damage. This can help reduce elevated liver enzyme levels and support overall liver function. It should only be used after proper evaluation and diagnosis by your doctor.

Does Ursodex 300mg Tablet cause weight gain?

Although uncommon, Ursodex 300mg Tablet may lead to weight gain, which has been reported in some patients with specific liver conditions, where bile flow was reduced. The likelihood varies depending on the underlying diseases and individual response. If you notice unexpected weight gain while taking Ursodex 300mg Tablet, please consult your doctor.

What should be avoided while taking Ursodex 300mg Tablet?

While taking Ursodex 300mg Tablet, avoid certain medications, such as antacids, cholestyramine, and colestipol, as they may reduce its effectiveness. Hormonal medications that contain estrogen and drugs such as clofibrate may increase the risk of gallstones and interfere with the treatment. Alcohol should be limited or avoided because it can strain the liver and reduce the protective effects of Ursodex 300mg Tablet. Always inform your doctor about all medications, supplements, and your lifestyle habits.

Can the body become resistant to Ursodex 300mg Tablet?

The body typically does not develop resistance to Ursodex 300mg Tablet, unlike with antibiotics. However, if gallstones become hardened with calcium and do not dissolve with Ursodex 300mg Tablet, or if bile flow does not improve and liver enzyme levels remain elevated, it may indicate progression of the underlying condition.

Are there specific food interactions with Ursodex 300mg Tablet?

There are no strict food restrictions while taking Ursodex 300mg Tablet, but it is best to avoid very greasy or spicy foods, as they can trigger gallbladder discomfort and worsen symptoms. A balanced, high-fiber diet may support digestion and overall treatment effectiveness. Always follow any specific dietary recommendations your doctor provides.

How does Ursodex 300mg Tablet dissolve gallstones?

Ursodex 300mg Tablet works by altering bile composition in the gallbladder, creating conditions that allow cholesterol gallstones to slowly dissolve back into liquid bile. This process is gradual and only works for stones primarily made of cholesterol. The gallbladder must still be functioning properly for treatment to be effective. Your doctor may recommend periodic ultrasounds to monitor the treatment progress.

How long can I safely take Ursodex 300mg Tablet?

The duration of treatment with Ursodex 300mg Tablet depends on your medical condition and response to therapy. For fatty liver disease, it may be prescribed for a few months, while chronic conditions such as primary biliary cholangitis may require long-term use. When taken under medical supervision, Ursodex 300mg Tablet is generally safe for extended treatment. Regular blood tests and imaging studies may be needed to monitor your liver function and ensure ongoing safety and effectiveness.

Can Ursodex 300mg Tablet affect your skin or hydration?

In rare cases, Ursodex 300mg Tablet may cause dry skin or a mild rash. Staying well hydrated supports overall health and liver function. Drinking adequate fluids and using a gentle moisturizer may help if mild dryness occurs. If you experience a severe skin reaction, stop taking Ursodex 300mg Tablet and contact your doctor immediately.

What warning signs should you watch out for?

You should seek immediate medical attention if you develop severe right-sided abdominal pain, intense yellowing of the skin or eyes (jaundice), or severe and persistent diarrhea. These symptoms may indicate a blocked bile duct or a rare, serious reaction. Any unusual or worsening symptoms should be reported to your doctor promptly.

Fact Box

Chemical Class

Dihydroxy bile acid derivative

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Hepatoprotective Agents

Related lab tests

Liver Function Test

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Aspo Healthcare Pvt. Ltd
Address: PLOT NO 427, SECTOR 2,HSIIDC,SAHA Ambala Haryana,133104

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Ursodex 300mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Ursodex 300mg Tablet

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Ursodex Tablet

Benefits of Ursodex Tablet

Side effects of Ursodex Tablet

How to use Ursodex Tablet

How Ursodex Tablet works

All substitutes for Ursodex 300mg Tablet

Ursolid 300mg Tablet

Udinol 300mg Tablet

Udiliv 300 Tablet

Actibile 300 Tablet

Ursetor 300 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Magaldrate (Oral Route)

Allylestrenol (Oral Route)

Bezafibrate (Oral Route)

Cholestyramine (Oral Route)

Colesevelam (Oral Route)

Frequently asked questions

How should Ursodex 300mg Tablet be taken to ensure maximum absorption?

What are the side effects of Ursodex 300mg Tablet?

What is Ursodex 300mg Tablet and what is it used for?

Does Ursodex 300mg Tablet cause weight gain?

What should be avoided while taking Ursodex 300mg Tablet?

Can the body become resistant to Ursodex 300mg Tablet?

Are there specific food interactions with Ursodex 300mg Tablet?

How does Ursodex 300mg Tablet dissolve gallstones?

How long can I safely take Ursodex 300mg Tablet?

Can Ursodex 300mg Tablet affect your skin or hydration?

What warning signs should you watch out for?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Liver Function Test

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests