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Bezafibrate is used to lower high level of fats (lipids) in the blood especially triglycerides and very-low-density lipoprotein (VLDL) along with a low fat diet, weight loss and exercise.

How it works

Bezafibrate belongs to a class of drugs called fibrates which acts by increasing the production of an enzyme (lipoprotein lipase) which causes breaking down (catabolism) of triglyceride-rich fat molecule. Elevated VLDL and LDL (low-density lipoprotein) are also reduced by treatment with Bezafibrate, whilst HDL (High density lipoprotein) levels are increased.

Common side effects

Increased sensitivity to light, Itchy rash, Difficulty in swalloing, Shortness of breath, Diarrhoea, Facial swelling, Abdominal bloating, Hair loss, Headache, Indigestion, Loss of appetite, Feeling of discomfort, Muscle weakness, Dizziness, Stomach disorders


Expert advice

  • You should use Bezafibrate along with diet, physical activity, weight loss and after adequate treatment of other metabolic disorders (e.g. diabetes, gout).
  • Bezafibrate may cause severe muscle pain/ damage (myopathy/Rhabdomyolysis) with increase in creatine kinase (CPK). You should be monitored periodically (through CPK and Liver Enzyme levels) for myopathy. 
  • Bezafibrate should be used with caution in combination with statins as the combination may increase the incidence and severity of myopathy.
  • Before taking Bezafibrate, make sure that the secondary causes of dyslipidemia, such as uncontrolled type 2 diabetes mellitus, hypothyroidism, nephrotic syndrome, dysproteinemia, obstructive liver disease and alcoholism have been adequately treated.
  • If you have impaired kidney function, you may need regular monitoring while on bezafibrate therapy.
  • Bezafibrate may cause dizziness. Do not drive or operate machinery until you feel fine.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions


Q. Is Bezafibrate a statin?
No. Bezafibrate is not a statin.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)