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Tacrolius 0.03 Ointment

Tacrolimus (0.03% w/w)
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Tacrolius 0.03 Ointment is used to treat eczema (atopic dermatitis). It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 17 Jan 2026 | 07:38 PM (IST)
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Tacrolius 0.03 Ointment image
Tacrolius 0.03 Ointment image
Tacrolius 0.03 Ointment image

Product introduction

Tacrolius 0.03 Ointment is used for external use. It should be used 2-4 times a day on the affected area, or use it as suggested by the doctor. It should be applied slowly and evenly to the skin until it is rubbed in. You should not use it too often, and you should not cover the treated area with a bandage or plaster. You must inform your doctor if there’s no improvement even after two weeks of treatment or if the skin gets worse.


Use of this medicine may cause some common side effects such as erythema, headache, inflammation of the hair follicle, and application site reactions like burning, irritation, itching, and redness. This medicine is not normally recommended during pregnancy or while breastfeeding unless it is clearly needed.

Uses of Tacrolius Ointment

Benefits of Tacrolius Ointment

Treatment of Atopic dermatitis
Atopic dermatitis, also known as eczema, is a chronic skin condition causing red, itchy, and inflamed patches on the skin, often associated with allergies. Tacrolius 0.03 Ointment when applied topically suppresses the immune response in the skin, reducing the inflammatory reactions that lead to eczema flare-ups. This way, it provides relief and helps improve the quality of life for individuals with atopic dermatitis.

Side effects of Tacrolius Ointment

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tacrolius
  • Application site reactions (burning, irritation, itching and redness)
  • Skin infection
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Rash
  • Application site tingling
  • Increased skin sensitivity

How to use Tacrolius Ointment

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and gently massage the ointment.

How Tacrolius Ointment works

Tacrolius 0.03 Ointment is an immunosuppressant. It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis.

Quick tips

  • Tacrolius 0.03 Ointment is effective at treating eczema (atopic dermatitis) when other treatment options have failed.
  • Apply thinly to affected areas of skin only. Clean the affected area and dry well before applying Tacrolius 0.03 Ointment. Avoid contact with water after application.
  • Inform your doctor if there's no improvement even after two weeks of treatment, or if the skin gets worse.
  • Don't cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
  • Stop using Tacrolius 0.03 Ointment and consult your doctor if your eczema becomes infected.
  • Continuous long-term use of the ointment should be avoided. Use as prescribed by your doctor.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Information regarding the use of Tacrolius 0.03 Ointment during pregnancy is not available. Please consult your doctor.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Tacrolius 0.03 Ointment may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Interaction with drugs

Taking Tacrolius with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Mild

Clarithromycin (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Clarithromycin may decrease the metabolism of Tacrolimus.
Mild

Clarithromycin (Injection Route)

Talk to your doctor if you notice any unusual symptoms. Clarithromycin may decrease the metabolism of Tacrolimus.

Frequently asked questions

Tacrolius 0.03 Ointment is used to treat moderate to severe eczema (atopic dermatitis) in adults who do not respond to steroids or develop side effects when using them. In atopic dermatitis, the skin’s immune system undergoes an overreaction, causing skin inflammation, leading to itchiness, redness, and dryness. Tacrolius 0.03 Ointment acts on the abnormal immune response and alters it, thereby relieving the skin inflammation and itchiness.
Compared to other immunosuppressing medicines, Tacrolius 0.03 Ointment is a safe and effective short-term treatment for atopic dermatitis. When applied to the affected part of the skin, its absorption into the blood and body is minimal. Hence, the side effects are less compared to when taken through the oral route.
Long-term use of Tacrolius 0.03 Ointment has been found to have an increased risk of lymph node tumors called lymphoma. Some studies have found that a few patients who used Tacrolius 0.03 Ointment ointment or another similar medication developed skin cancer or lymphoma. Consult your doctor if you have to use Tacrolius 0.03 Ointment ointment for more than 6 weeks or if your eczema symptoms have not improved or are getting worse with time during your treatment.
No, Tacrolius 0.03 Ointment is not a steroid. It is a medicine that modulates the working of the immune system. It is used in the treatment of eczema, most commonly in atopic dermatitis. An advantage of Tacrolius 0.03 Ointment is that it does not cause skin thinning (atrophy) or other steroid-related side effects.

Fact Box

Chemical Class

Macrolide lactams

Habit Forming

No

Therapeutic Class

DERMA

Action Class

Calcineurin Inhibitors

References

  1. Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1822.
  2. Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 972.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1305-309.
  4. Tacrolimus monohydrate [EMC SmPC]. Hurley, Berkshire: Leo Laboratories Limited; 2018. [Accessed 17 Apr. 2019] (online) Available from:
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 06 Apr. 2019] (online) Available from:
  6. Tacrolimus [Prescribing Information]. Dublin, Ireland: LEO Laboratories Ltd.; 2022. [Accessed 01 Aug. 2023]. (online) Available from:
  7. Tacrolimus monohydrate [Package Leaflet: Information for User]. Killorglin, Ireland: Astellas Ireland Co. Ltd.; 2024.
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Prevego Healthcare & Research Private Limited
Address: Satyam Medical, Room No.9, Ground Floor, Laxmi Niwas 4-6, Bora Bazar Street, Fort Mumbai City MH 400001

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Tacrolius 0.03 Ointment. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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