Important Drug Alert for Diabetics


By Dr Rakesh Ramakrishna Sonawane, MD Pharmacology

The U.S. Food and Drug Administration (FDA) has recently issued warnings for two commonly used drugs for type 2 diabetes. Read the article carefully if you or your loved one is on any medication for the treatment of diabetes.

1 . DPP-4 inhibitors (common brand names : Janumet, Galvus Met, Januvia, Istamet, Jalra-M)

Drugs belonging to the class DPP-4 inhibitors with salts like sitagliptin, saxagliptin, linagliptin, and alogliptin are used in people  with type 2 diabetes to control blood sugar levels. These medicines are available as single-ingredient products and in combination with other diabetes medicines such as metformin.

What is the warning?

FDA has issued a warning that these medicines (sitagliptin, saxagliptin, linagliptin, and alogliptin) may cause joint pain that can be severe and disabling. FDA has added a new warning about this risk to the labels of all medicines in this drug class. The warning was issued after few patients reported having severe joint pains while taking these medicines. The pain settled when they stopped taking the medicines.

Next steps?

Patients are advised not to stop taking their medicine, but contact their doctor right away if they experience severe and persistent joint pain.

2 . Canagliflozin (common brand names : Invokana, Sulisent)

Canagliflozin is a medicine prescribed for diabetes management to help in controlling blood sugar levels. Canagliflozin lowers blood sugar by causing the kidneys to remove sugar from the body through the urine.

What is the warning?

According to new data released by FDA, fractures occur more frequently in people who take  canagliflozin. Fractures can occur as early as 12 weeks after starting the drug. It was also noted that the drug  decreases bone mineral density at the hip and lower spine. A study conducted over two years in 714 elderly individuals showed that canagliflozin caused greater loss of bone mineral density at the hip and lower spine than a placebo.

Next steps?

Patients taking this medicine should not stop taking this medicine without consulting their doctor.

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5 thoughts on “Important Drug Alert for Diabetics

  1. Akshay jain

    My diabetes 121 morning after lunch 190 so me all controls diabetes so muje ab kiya karna hai

  2. R.K jindal

    I am taking Zita plus containing salt
    Teniligliptin20 mg for the last 3 months
    And I am facing problem mentioned by your website. The severe joint pain.please advice

  3. Pingback: Now Diabetics Can Have Once-A- Week Medications! – 1mg Capsules