What is Coagulation Profile?
Coagulation profile is done to determine proper concentrations of coagulation factors in the blood. This test includes two tests, namely, Activated Partial Thromboplastin Time test and Prothrombin Time test.
Why is Coagulation Profile done?
Coagulation Profile is done:
In case of excessive unexplained bleeding
In case of easy bruising
In acute conditions such as Disseminated intravascular coagulation
In chronic conditions such as liver disease
To monitor the patients taking medicines affecting clotting ability
What does Coagulation Profile Measure?
Coagulation profile measures the activated partial thromboplastin time and prothrombin time.
Prothrombin is a protein which is produced by the liver. Prothrombin time determines the time your blood will take to clot. The Prothrombin time increases in case the patient is on blood-thinning medications or has hemophilia or liver disease. Malabsorption of the prothrombin protein may also affect the results of prothrombin time. This test is also done in patients who are taking medicines that affect the clotting time such as warfarin.
The doctor advises the prothrombin test with another clotting test known as activated partial thromboplastin time (aPTT).
The aPTT is also known as PTT (Partial Thromboplastin Time). The aPTT test helps to determine the ability of a person to form blood clots appropriately. The aPTT test measures the number of seconds taken by a clot to form in a sample of blood after the addition of reagents. This test assesses the amount and function of clotting factors.
Hemostasis is the process which is initiated by the body when there is an injury to the body tissues or walls of blood vessels. In this process, the platelets combine at the site of injury and a simultaneous process of coagulation gets activated, leading to further activation of the coagulation factors. As a result of this process, the fibrin threads are formed which form a net and get attached to the site of injury. This helps in stabilizing the site of injury, further leading to the formation of a stable blood clot to seal off the injury to blood vessels. It also helps in the prevention of additional blood loss which allows the damaged areas to heal.
The PTT evaluates the coagulation factors XII, XI, IX, VIII, X, V, II (prothrombin), and I (fibrinogen) as well as prekallikrein (PK) and high molecular weight kininogen (HK).
A PT test evaluates the VII, X, V, II, and I coagulation factors.
Interpreting Coagulation Profile results
Prothrombin time: 9.57 s - 11.80 s
Activated partial thromboplastin time: 23.57 s - 29.33 s
Reference range may vary from lab to lab*
Results of PT
Results of PTT
Can be seen in the following conditions
Diseases of liver, Vitamin K deficiency, Defective factor VII, Chronic disseminated intravascular coagulation
Hemophilia A or B, Factor XI deficiency, Von Willebrand disease, Factor XII deficiency, Presence of lupus anticoagulant
Defective factor I, II, V or X, Severe liver disease, Acute disseminated intravascular coagulation
Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Coagulation Profile
Frequently Asked Questions about Coagulation Profile
Tests Included (2 tests)
- Prothrombin Time