Celiac Disease Panel, IgG by LIA

Celiac disease is an autoimmune disorder in which the ingestion of gluten leads to damage in the small intestine, causing inflammation, poor nutrient absorption, and a range of digestive and non-digestive symptoms. The disease typically manifests within the first few years of life, but sometimes also in adulthood. Early detection is important to prevent long-term complications such as anemia, bone weakness, and other autoimmune conditions.

When gluten is eaten, it is broken down into smaller pieces, including gliadin, which is modified by an enzyme called tissue transglutaminase (tTG). The immune system attacks the modified (deamidated) form, leading to inflammation and damage to the lining of the small intestine. The Celiac Disease Panel, IgG by LIA is tailored to help evaluate these immune responses to gluten. This panel includes Tissue Transglutaminase (tTG) Antibody IgG and Deamidated Gliadin Peptide (DGP) IgG. After starting a strict gluten-free diet, antibody levels gradually fall and may become undetectable within 1 to 12 months.

The panel is recommended for individuals having persistent digestive symptoms such as chronic diarrhea, bloating, abdominal pain, or unexplained weight loss, or who show signs of malabsorption like anemia, vitamin deficiencies, or low bone density. It may also be advised for people with fatigue, skin rashes, or neurological symptoms where celiac disease is suspected. Additionally, individuals with a family history of celiac disease or autoimmune disorders, such as type 1 diabetes or thyroid disease, may be recommended to this panel for early screening. It is interesting to note that Deamidated Gliadin IgG antibodies may sometimes be seen in other intestinal conditions such as Crohn's disease (seen in about 40–50% of cases) and Ulcerative colitis (about 10–20%).

No special preparation is required for this panel. However, for an accurate diagnosis, individuals may be advised by their doctor to continue consuming foods that contain gluten for a specific period before testing. 

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results. Based on the findings, a doctor may recommend dietary modifications, nutritional supplementation, or additional diagnostic evaluations.