
SSA - RO (Soluble Substance A)- IgG antibody









The SSA - RO (Soluble Substance A)- IgG antibody test detects the presence of SSA (Ro) antibodies in the blood. These autoimmune antibodies, which are important markers for systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS), help support the diagnosis of these conditions.













Understanding SSA - RO (Soluble Substance A)- IgG antibody
The SSA - RO (Soluble Substance A)- IgG antibody test is used to detect autoantibodies directed against SS-A (Ro) antigens, which are proteins found inside cells that the immune system may mistakenly target. These antibodies are commonly seen in autoimmune diseases, especially Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE). The presence of these antibodies may also be associated with other connective tissue disorders.
The SSA - RO (Soluble Substance A)- IgG antibody test is often recommended when symptoms like dry eyes, dry mouth, joint pain, fatigue, or skin rashes are present. It is also useful during pregnancy to assess risk in women with autoimmune diseases, as SS-A antibodies may affect the fetus, causing issues like congenital heart block.
Detecting Anti-SS-A antibodies helps doctors support the diagnosis, distinguish between overlapping autoimmune conditions, and plan appropriate treatment.
No special preparation is required for the SSA - RO (Soluble Substance A)- IgG antibody test. Inform the doctor about all the medications and supplements being taken, as some of them may affect the test results. Your doctor may advise changes if needed before the test.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate and always consult a doctor to understand the test results correctly.
Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does SSA - RO (Soluble Substance A)- IgG antibody measure?
The SSA - RO (Soluble Substance A)- IgG antibody is a blood test that detects IgG autoantibodies that react against SS-A (Ro) antigens. A positive result suggests an autoimmune response and helps confirm disorders such as lupus or Sjögren’s syndrome.





FAQs related to SSA - RO (Soluble Substance A)- IgG antibody
- Provost TT. Anti-Ro(SSA) and anti-La(SSB) antibodies in lupus erythematosus and Sjögren's syndrome. Keio J Med. 1991 Jun;40(2):72-7. [Accessed 05 Aug. 2025]. Available from:
- Jia Y, Luan S, Huang S, Zhang W, Li M, Xu T, Fei Y. Prevalence and clinical significance of anti-SSA antibody in the Chinese health screening population. Clin Exp Immunol. 2024 Oct 16;218(2):169-176. [Accessed 05 Aug. 2025]. Available from:
- Yoshimi R, Ueda A, Ozato K, Ishigatsubo Y. Clinical and pathological roles of Ro/SSA autoantibody system. Clin Dev Immunol. 2012;2012:606195. [Accessed 05 Aug. 2025]. Available from:
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