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Understanding the Test
Test Measures
Interpreting Results
FAQ's
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References
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CA19.9

Also known as Pancreatic Cancer Marker, Cancer Antigen-GI
10991500 26% Off
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.
  2. Provide brief clinical history/ doctor's prescription at the time of sample collection.

Understanding CA19.9


What is CA19.9?

A CA19.9 test, also known as carbohydrate antigen 19.9, is a blood test used to measure the levels of CA 19.9 protein in the blood. CA 19.9 is a tumor marker that may be increased in individuals with certain types of cancer, particularly pancreatic cancer and some non-cancerous conditions. This test helps diagnose cancer, monitor cancer treatment response, and detect cancer recurrence post-treatment.

CA19.9, a carbohydrate-rich glycoprotein known as mucin, is an important biomarker associated frequently associated with pancreatic cancer. However, increased CA 19.9 levels may also be seen in other cancers, including colorectal, gastric, hepatobiliary, and ovarian cancer. Additionally, the levels of CA19.9 may be elevated in non-cancerous conditions such as pancreatitis, cirrhosis, benign gallbladder disease (cholestasis), and cystic fibrosis. Hence, it is important to note that a CA19.9 test is not a standalone test, and other confirmatory procedures, such as medical history, clinical findings, imaging studies, or biopsies, may be necessary to validate cancer diagnosis.

Single values of CA19.9 are less informative. Hence, serial measurements over time, beginning before treatment, are preferred. Changes in CA 19.9 levels over time with disease progression or therapy may reflect the effectiveness of treatment and help guide further management decisions. A persistently high CA19.9 value may indicate disease progression, poor response to treatment, or even metastasis (tumor spread). Additionally, there is no correlation between the size of the tumor and the CA19.9 assay values. Patients with confirmed cancer may have a normal range before treatment initiation.

No special preparations are required before undergoing a CA19.9 test. However, it is important to provide a brief clinical history or doctor's prescription at the time of sample collection.  

Test results may vary across laboratories, and values obtained with different test methods should not be used interchangeably. An expert should interpret results in conjunction with clinical findings and other diagnostic tests to guide appropriate patient care and optimized treatment outcomes.

What is CA19.9 used for?

A CA19.9 test is done: 

  • As an adjunct to other diagnostic tests to aid in diagnosing pancreatic cancer.
  • To differentiate between benign and malignant conditions in the pancreas and other related organs.
  • To monitor cancer progression and assess the treatment response.
  • To detect potential cancer recurrence. 
  • To monitor other non-cancerous conditions like pancreatitis, cirrhosis, etc, or various other cancers, including colorectal, gastric, hepatobiliary, and ovarian cancer.

What does CA19.9 measure?

The  CA19.9 test measures the level of a specific tumor marker called CA 19.9 in the blood, often associated with gastrointestinal cancers, particularly pancreatic cancer. This biomarker is produced by certain cells in the body, specifically epithelial cells. These cells are found in various tissues, including the gastrointestinal tract. Elevated levels of CA 19.9 are often associated with cancers that involve these tissues, such as pancreatic, colorectal, and gastric cancers. However, CA 19.9 can also be produced by non-cancerous conditions, impacting its specificity as a diagnostic marker. For a comprehensive evaluation, it is advised to consider other diagnostic tests in conjunction with CA19.9 test and consult a doctor for a proper understanding of the test results.

Interpreting CA19.9 results


Interpretations

 

Disease

%age positivity of CA 19-9

Pancreatic cancer

80

Hepatobiliary cancer

67

Gastric cancer

40 - 50

Hepatocellular cancer

30 - 50

Colorectal cancer

30

Breast cancer

15

Pancreatitis

10 - 20

Benign gastrointestinal diseases

10 - 20

 

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about CA19.9


Frequently Asked Questions about CA19.9

Q. When should I get the CA19.9 test?

Get a CA19.9 test when recommended by your doctor, typically if you have symptoms or risk factors associated with gastrointestinal cancers, particularly pancreatic cancer. It is a part of a comprehensive evaluation and not a routine screening test.

Q. Is there any risk associated with a CA19.9 test?

No, there is no risk associated with CA19.9. However, some individuals may feel a slight sting when a needle is pricked and experience some bleeding that is normal and usually not bothersome. Rarely, some individuals may also experience slight swelling or bruising at the site of the needle prick. Applying ice 3-4 times a day for about a week may help reduce swelling and bruising. If it does not get better, consult your doctor.

Q. Is CA19.9 test a definitive diagnostic test for pancreatic cancer?

No, CA19.9 test is not a definitive test for pancreatic cancer. Elevated levels can indicate various conditions. A comprehensive evaluation, including imaging and clinical assessment, is necessary for establishing a proper diagnosis.

Q. What factors can affect my CA 19.9 levels?

CA 19.9 levels can be influenced by various factors, including non-cancerous conditions like pancreatitis, as well as lifestyle choices such as alcohol consumption and smoking. Always consult a doctor for a comprehensive interpretation of your test results based on your individual condition.

Q. What are the signs and symptoms of pancreatic cancer?

The common signs and symptoms of pancreatic cancer include abdominal pain, jaundice, unexplained weight loss, changes in stool color, and other digestive problems. However, these symptoms can be caused by various other conditions as well.

Q. What are the risk factors of pancreatic cancer?

The common risk factors of pancreatic cancer include obesity, diabetes, unhealthy food choices, alcohol, smoking, pancreatitis, or a family history of pancreatic cancer.
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CA19.9 test price for other cities


Price inMumbaiRs. 1099
Price inBangaloreRs. 1099
Price inKolkataRs. 1099
Price inGurgaonRs. 1099
Price inPuneRs. 1099
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References

  1. CA 19-9 [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 20 Dec. 2023]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=207&contentid=ca_19_9 External Link
  2. Ballehaninna UK, Chamberlain RS. The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: An evidence based appraisal. J Gastrointest Oncol. 2012 Jun;3(2):105-19. [Accessed 20 Dec. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397644/ External Link
  3. Ballehaninna UK, Chamberlain RS. Serum CA 19-9 as a Biomarker for Pancreatic Cancer-A Comprehensive Review. Indian J Surg Oncol. 2011 Jun;2(2):88-100. [Accessed 20 Dec. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244191/ External Link
  4. Puckett Y, Garfield K. Pancreatic Cancer. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK518996/ External Link
  5. Vincent A, Herman J, Schulick R, Hruban RH, Goggins M. Pancreatic cancer. Lancet. 2011 Aug 13;378(9791):607-20. [Accessed 20 Dec. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062508/ External Link
  6. Zhao Z, Liu W. Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820962117. [Accessed 20 Dec. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768873/ External Link
  7. Wu E, Zhou S, Bhat K, Ma Q. CA 19-9 and pancreatic cancer. Clin Adv Hematol Oncol. 2013 Jan;11(1):53-5. PMID: 23596673; PMCID: PMC3633106. [Accessed 20 Dec. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633106/ External Link
  8. Ballehaninna UK, Chamberlain RS. Serum CA 19-9 as a Biomarker for Pancreatic Cancer-A Comprehensive Review. Indian J Surg Oncol. 2011 Jun;2(2):88-100. [Accessed 20 Dec. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/22693400/External Link
  9. Wang F, Herrington M, Larsson J, Permert J. The relationship between diabetes and pancreatic cancer. Mol Cancer. 2003 Jan 6;2:4. [Accessed 20 Dec. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149418/External Link

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