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ADA (Adenosine Deaminase), Serum

Also referred as

Adenosine Deaminase (ADA) test

For men & women

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The ADA (Adenosine Deaminase), Serum test is a blood test used to measure the level of adenosine deaminase, an enzyme vital to the functioning of the immune system. This test helps diagnose conditions like tuberculosis (TB) and assess immune system disorders, particularly those affecting white blood cells.

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Blood

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No special preparation is required.

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Understanding ADA (Adenosine Deaminase), Serum

Adenosine deaminase (ADA) is an enzyme that plays a key role in purine metabolism, which is important for the breakdown of nucleotides (building blocks of DNA and RNA) in the body. It is primarily found in the liver, kidneys, and immune cells, especially lymphocytes. ADA is involved in the immune response and helps regulate the growth and function of T-cells, a type of white blood cell critical for immune defense. The ADA (Adenosine Deaminase), Serum test is commonly used to evaluate the presence of infections, particularly tuberculosis, which can cause inflammation and fluid accumulation in the lungs.

The ADA (Adenosine Deaminase), Serum test is recommended when a doctor suspects an infection such as tuberculosis, especially when there are signs of a lung infection or pleural effusion (fluid buildup around the lungs). Symptoms may include cough, chest pain, fever, shortness of breath, night sweats, etc. This test is also used to evaluate other conditions where the immune system might be compromised or overactive, such as in autoimmune diseases or certain types of cancers. Additionally, it is done when there are risk factors for TB, such as close contact with a TB-infected person, as well as to monitor treatment progress for infections like tuberculosis.

No special preparation is required for this test. However, inform the doctor about all the medications or supplements being taken, as these may affect the test results, potentially requiring adjustments or temporary discontinuation. Narrate the complete medical history to help doctors relate the clinical and laboratory findings.

Lab test results may vary across laboratories. Do not self-medicate. Always consult the doctor to understand the test results correctly. The insights from ADA (Adenosine Deaminase), Serum test will help doctors formulate the overall treatment plans.

Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.

What does ADA (Adenosine Deaminase), Serum measure?

The ADA (Adenosine Deaminase), Serum test measures the level of adenosine deaminase enzyme (ADA) in the blood or body fluids ( like pleural fluid, peritoneal fluid, pericardial fluid,etc.) ADA plays a key role in the immune system by helping regulate the function of T lymphocytes, which are vital for fighting infections. High ADA levels are typically associated with tuberculosis, as the body's immune response to the infection increases ADA production. Elevated ADA can also be seen in other diseases involving the immune system, such as certain cancers and immune deficiencies. On the contrary, low levels of ADA can indicate a weakened immune response, which may occur in conditions like immunodeficiencies or after immunosuppressive therapy.

Therefore, getting tested with the ADA (Adenosine Deaminase), Serum test helps doctors evaluate a wide range of infections and immune-related disorders.

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FAQs related to ADA (Adenosine Deaminase), Serum

What is the ADA (Adenosine Deaminase), Serum test?

The ADA (Adenosine Deaminase), Serum test is a blood test that measures the level of adenosine deaminase, an enzyme produced primarily by the immune system. This test is used to help diagnose and monitor infections, particularly tuberculosis (TB) and assess immune system health.

Why is the ADA (Adenosine Deaminase), Serum test performed?

This test is commonly used to diagnose tuberculosis (TB), especially when it affects the lungs or pleura (the lining around the lungs). It is also used to evaluate other conditions where the immune system may be involved, such as sarcoidosis, HIV, and certain cancers.

How is the ADA (Adenosine Deaminase), Serum test performed?

A phlebotomist (a trained professional to perform blood draws) will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.

Do I need to fast before taking the ADA (Adenosine Deaminase), Serum test?

No fasting is required for this test. You can schedule it at your convenience without avoiding food or water beforehand.

How frequently should this test be done?

The frequency of this test depends on your health condition, especially if you are undergoing treatment for pleural tuberculosis. Your doctor will provide guidance on how often you should get tested.

What do elevated levels of ADA indicate?

Elevated ADA levels are commonly associated with tuberculosis, particularly in the lungs and pleura. However, they can also indicate other conditions like sarcoidosis, fungal infections, HIV, and some cancers. High levels are typically seen in cases of inflammation and immune activation.

What do low levels of ADA indicate?

Low ADA levels can suggest a weakened immune system, which may occur in conditions like immunodeficiency diseases or after treatments that suppress the immune response, such as chemotherapy or immunosuppressive drugs.

Can the ADA (Adenosine Deaminase), Serum test be used to diagnose tuberculosis on its own?

The ADA (Adenosine Deaminase), Serum test can be an important diagnostic tool for tuberculosis, but it is not definitive on its own. It is used in conjunction with other diagnostic methods, such as imaging tests, sputum cultures, and chest X-rays, to confirm the diagnosis of tuberculosis.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

8th Nov 2025