Zolefix 100 Capsule

Itraconazole (100mg)

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Zolefix 100 Capsule belongs to a group of medicines called antifungals. It works by stopping the growth of fungi and is used to treat infections of the mouth, throat, vagina, and other parts of the body including fingernails and toenails. It kills fungi by destroying the fungal cell membrane.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 14 Apr 2026 | 04:21 PM (IST)

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Itracip 100 Capsule

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Zolefix 100 Capsule

strip of 10 capsules

₹124

~~₹140.63~~

Same composition

Itracip 100 Capsule

strip of 4 capsules

Itraconazole (100mg)

by Cipla Ltd

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₹37.2

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General Information

Contains

Itraconazole (100mg)

Marketer

Ximing Labs Pvt Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Zolefix 100 Capsule should be taken in the dose and duration as prescribed by your doctor. It should be swallowed whole and can be taken with food. To get the most benefit, take this medicine at evenly spaced times and continue using it until your prescription is finished, even if your symptoms disappear after a few days. If you stop the treatment too early, the infection may return and if you miss doses you can increase your risk of infections that are resistant to further treatment. Tell your doctor if the infection does not get better or if it gets worse.

The most common side effects of this medicine include nausea, dizziness, headache, vomiting, diarrhea, abdominal pain, constipation, and dyspepsia. You could ask your doctor about ways of preventing or reducing these effects. Get emergency medical help if you have signs of an allergic reaction like severe skin rash, tingling, difficulty breathing, swelling of your face, lips, tongue, or throat.

Do not take it if you are pregnant or could become pregnant unless your doctor has told you to. Talk to your doctor before taking this medicine if you have a history of heart failure, a weak immune system (including HIV/AIDS), kidney problems, or liver problems such as yellow skin (jaundice). This medicine may not be suitable for you. If your course of treatment is for more than a month, your doctor may want to check your liver by testing your blood.

Uses of Zolefix Capsule

Treatment of Fungal infections

Benefits of Zolefix Capsule

Treatment of Fungal infections
Zolefix 100 Capsule is an antifungal medicine. It is used to treat infections in different parts of the body caused by fungi. It works by killing and stopping the growth of fungi. This provides relief from various symptoms caused by the infection and speeds up the healing process. You should keep taking the medicine until you complete the dose even if you get better. This will prevent the infection from returning.

Side effects of Zolefix Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zolefix

Headache
Nausea
Abdominal pain

How to use Zolefix Capsule

Take this medicine in the dose and duration as advised by your doctor. Zolefix 100 Capsule should be taken with or after food.

How Zolefix Capsule works

Zolefix 100 Capsule is an antifungal medication. It kills fungi by destroying the fungal cell membrane. This treats your skin infection.

All substitutes for Zolefix 100 Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Zolefix 100 Capsule helps treat fungal infections of mouth, skin, vagina or any other parts of the body.
Do not skip any doses and finish the full course of treatment even if you feel better.
Take it with food, preferably at the same time everyday.
Use a reliable method of contraception to prevent pregnancy while taking this medicine.
Do not take indigestion remedies (antacids) within 2 hours of taking Zolefix 100 Capsule.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Inform your doctor if you develop allergic reactions, nerve pain, or hearing loss.
Your doctor has prescribed Zolefix 100 Capsule to cure your infection and improve symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Zolefix 100 Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Zolefix 100 Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Zolefix 100 Capsule should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Zolefix 100 Capsule alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Zolefix 100 Capsule should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Zolefix 100 Capsule in patients with liver disease.
Inform your doctor if you develop signs of jaundice like yellowing of eyes and skin, itching, and clay colored stools while taking this medicine.

Interaction with drugs

Taking Zolefix with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Ranolazine (Oral Route)

Do not consume Ranolazine with Itraconazole.

Life-threatening

Methylergometrine (Oral Route)

Do not consume Methylergometrine with Itraconazole. Itraconazole may raise blood levels of Methylergometrine.

Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Itraconazole.

Life-threatening

Simvastatin (Oral Route)

Do not consume Simvastatin with Itraconazole. If Itraconazole is essential, your doctor may temporarily stop Simvastatin. Itraconazole may raise blood levels of Simvastatin.

Life-threatening

Ivabradine (Oral Route)

Do not consume Ivabradine with Itraconazole. Itraconazole may raise blood levels of Ivabradine.

Frequently asked questions

What is Zolefix 100 Capsule used for?

Zolefix 100 Capsule is used to treat fungal infections caused by Trichophyton spp., Microsporum spp., and Epidermophyton floccosum. The infections caused could be ringworm infection, infection of feet, or infection in groin and buttocks. This medicine also treats persistent infection of fingernails and toenails, persistent candida (yeast) infections of vagina or candida (yeast) infections of the mouth or throat in patients with lower resistance to disease. It is also used in the treatment of cryptococcal infection and infections caused by histoplasma, aspergillus and blastomyces.

For how long do I need to take Zolefix 100 Capsule?

The dose and length of treatment will depend on the type and site of infection and your response to the treatment. For example, if you are taking Zolefix 100 Capsule for athlete’s foot (fungal infection of the skin on the feet and between the toes), the dose may need to be taken for 30 days. While, on the other hand, if you are taking it for candidal infection of vagina, the dose may take about 1 to 3 3 days depending on the dosage advised by the doctor.

What should I do if I skip a dose of Zolefix 100 Capsule?

If you forget to take your dose, take the missed dose as soon as you remember. However, if it is time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the forgotten dose.

I am taking Zolefix 100 Capsule for nail infection but there does not seem to be any improvement. Can I stop taking it?

No, you should not stop taking Zolefix 100 Capsule without completing the entire course. This is because if you stop the medication then your fungal infection may not get completely cured. It usually takes about 6-9 months for the nail lesions to get cured and after that the new nail also takes several months to grow. Therefore, do not worry if you do not see any improvement during the treatment.

Why has my doctor asked me to get blood tests done?

Your doctor may have prescribed blood tests to monitor your liver’s functioning. This is because the use of Zolefix 100 Capsule may cause serious liver damage. Therefore, if you develop loss of appetite, nausea, vomiting, dark urine or abdominal pain while taking Zolefix 100 Capsule, immediately inform your doctor.

Can I take an antacid and Zolefix 100 Capsule together?

Zolefix 100 Capsule can be utilized by the body if there is sufficient acid in the stomach. Medicines for stomach ulcers, heartburn or indigestion neutralize the acid produced by the stomach. Therefore, it is advised to avoid taking antacids or any such medicine for a minimum of 2 hours after taking Zolefix 100 Capsule. However, if you are taking antacids (medicines that stop the production of stomach acid), take Zolefix 100 Capsule capsules with a drink of cola.

What is drug resistance? Is it possible to develop resistance to Zolefix 100 Capsule?

Drug resistance is a condition when the fungi get modified in your body and the medicine is not able to work. There are reports which suggest resistance of some candida species (krusei, glabrata and tropicalis) with Zolefix 100 Capsule. Zolefix 100 Capsule should not be used for infection caused due to these species. It is advised to take the complete course of Zolefix 100 Capsule to avoid drug resistance.

I am on alprazolam for quite some time. Is it okay if I start Zolefix 100 Capsule now?

Yes, you can take both Alprazolam and Zolefix 100 Capsule together, but keep a watch on the side effects of Alprazolam such as lightheadedness or drowsiness. If you experience side effects after taking Zolefix 100 Capsule, talk to your doctor who will modify the dose of alprazolam.

My doctor prescribed Zolefix 100 Capsule to me but not to my friend who had a similar fungal infection because she was on dofetilide. Why is it so?

Your doctor did not prescribe Zolefix 100 Capsule to your friend because Zolefix 100 Capsule interferes with the working of dofetilide. This interference can cause disturbed electrical activity of the heart, which can be harmful for the patient.

Fact Box

Chemical Class

Phenylpiperazines

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Fungal Ergosterol Synthesis Inhibitor

Related lab tests

Culture Fungus

References

Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1576-79.
Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 839-40.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 749-51.
Itraconazole. Turnhout, Belgium: Sanico N.V.; 1992 [revised Apr. 2010]. [Accessed 29 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 29 Mar. 2019] (online) Available from:
New Zealand Data Sheet. Itrazole. Aukland, new Zealand: Viatris Ltd.; 2022. [Accessed 07 Jul. 2023]. (online) Available from:
Kurn H, Wadhwa R. Itraconazole. [Updated 2023 Apr 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 07 Jul. 2023]. (online) Available from:
Itraconazole. Titusville, NJ: Janssen Pharmaceuticals, Inc; 2023. [Accessed 18 Jan. 2026]. (online). Available from:

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