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Trajenta Duo 2.5mg/500mg Tablet

Metformin (500mg)+ Linagliptin (2.5mg)

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Trajenta Duo 2.5mg/500mg Tablet is a combination of two medicines used to help control high blood sugar levels in people with type 2 diabetes mellitus. It works by improving insulin action and reducing the amount of sugar produced by the liver.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Jan 2026 | 03:32 PM (IST)

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Trajenta Duo 2.5mg/500mg Tablet

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by Boehringer Ingelheim

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General Information

Contains

Metformin (500mg)+ Linagliptin (2.5mg)

Marketer

Boehringer Ingelheim

Storage

Store below 30°C

The content is shown in English

Product introduction

Trajenta Duo 2.5mg/500mg Tablet may be prescribed alone or together with other diabetes medications. It works best when combined with a healthy diet and regular exercise. The dosage depends on your condition, blood sugar levels, and other medications you are taking. Taking it with meals can help minimize the risk of an upset stomach. Take Trajenta Duo 2.5mg/500mg Tablet exactly as prescribed by your doctor.

Follow the recommended schedule to achieve the best results. Do not make changes to your dosage or stop taking it without consulting your doctor. Continue following the diet and exercise plan recommended by your doctor while using this medicine. Your lifestyle plays a big part in controlling diabetes.

The most common side effects of taking this medicine include headache, nausea, dizziness, and skin rash. Some people may experience low blood sugar (hypoglycemia), especially when taking this medicine with other diabetes treatments like insulin or sulfonylureas. If these side effects persist or worsen, consult your doctor.

Before taking Trajenta Duo 2.5mg/500mg Tablet, inform your doctor if you have a history of kidney, liver, or heart disease or any pancreatic issues. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some medicines can interact and affect the effectiveness of Trajenta Duo 2.5mg/500mg Tablet; tell your doctor about all the medicines you are taking to ensure it is safe for you. Avoid drinking alcohol, as it can lower blood sugar levels. Your doctor will monitor your kidney function and blood sugar levels before and during treatment. Trajenta Duo 2.5mg/500mg Tablet should not be used to treat type 1 diabetes.

Uses of Trajenta Duo Tablet

Treatment of Type 2 diabetes mellitus

Benefits of Trajenta Duo Tablet

Treatment of Type 2 diabetes mellitus
Trajenta Duo 2.5mg/500mg Tablet has two active substances in it i.e. metformin and linagliptin. Metformin belongs to a class of medicines called biguanides. Linagliptin belongs to a group called DPP-4 inhibitors. They work together in different ways to lower your blood glucose levels.

Lowering blood glucose levels is an essential part of managing diabetes. If you can control your blood glucose level, your risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs is also lowered. Additionally, proper control of diabetes can also reduce the risk of heart disease and stroke. Taking this medicine regularly along with a proper program of diet and exercise will help you live a normal, healthy life. You should keep using this medicine for as long as it is prescribed because it is protecting your future health.

Side effects of Trajenta Duo Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Trajenta Duo

Nausea
Headache
Dizziness
Vomiting
Fatigue
Skin rash
Abnormal liver function

How to use Trajenta Duo Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trajenta Duo 2.5mg/500mg Tablet should be taken with or after food.

How Trajenta Duo Tablet works

Trajenta Duo 2.5mg/500mg Tablet is a combination of two medicines: metformin and linagliptin. Metformin is an antidiabetic medication (biguanide). It lowers glucose production in the liver, slows glucose absorption in the intestine, and improves the body's insulin sensitivity. Linagliptin, a DPP-4 inhibitor, increases insulin release from the pancreas and reduces hormones that raise blood sugar levels. This reduces both fasting and post-meal sugar levels. Together, they provide better control of blood sugar.

All substitutes for Trajenta Duo 2.5mg/500mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Trajenta Duo 2.5mg/500mg Tablet should be taken with food to lower the chances of having an upset stomach.
Take it along with regular exercise and a healthy diet to help lower blood sugar levels.
Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol, or by delaying/skipping a meal. Carry a sugar source with you for immediate relief.
Monitor your blood sugar level regularly while on treatment with this medicine.
Inform your doctor about your diabetes treatment if you are due to have any surgery under a general anesthetic.
Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, or stomach pain, as Trajenta Duo 2.5mg/500mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Trajenta Duo 2.5mg/500mg Tablet

Pregnancy

CONSULT YOUR DOCTOR

The safety of Trajenta Duo 2.5mg/500mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Trajenta Duo 2.5mg/500mg Tablet may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

CAUTION

Trajenta Duo 2.5mg/500mg Tablet may affect your driving ability if your blood sugar becomes too low or too high. Monitor your blood glucose and avoid driving if affected.

Kidney

UNSAFE

Trajenta Duo 2.5mg/500mg Tablet is unsafe to use in patients with kidney disease and should be avoided.

Liver

UNSAFE

Trajenta Duo 2.5mg/500mg Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

Does the use of Trajenta Duo 2.5mg/500mg Tablet cause lactic acidosis?

Yes, the use of Trajenta Duo 2.5mg/500mg Tablet can lead to lactic acidosis, which is also known as MALA (metformin-associated lactic acidosis). It is caused by increased levels of lactic acid in the blood. It is a very rare side effect associated with the use of metformin, and therefore, it is avoided in patients with underlying kidney disease, elderly patients, or those who consume large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain, or slow heart rate. If you have these symptoms, stop taking Trajenta Duo 2.5mg/500mg Tablet and immediately consult your doctor.

What are the possible side effects of Trajenta Duo 2.5mg/500mg Tablet?

The use of Trajenta Duo 2.5mg/500mg Tablet may cause some common side effects like nausea, headache, dizziness, fatigue, vomiting, and skin rash. Patients may also experience hypoglycemia (low blood sugar level) when taken along with other antidiabetic medicines. It can also lead to a serious but rare side effect known as lactic acidosis. Additionally, its long-term use can also lead to vitamin B12 deficiency.

Are there any specific conditions in which Trajenta Duo 2.5mg/500mg Tablet should not be taken?

The use of Trajenta Duo 2.5mg/500mg Tablet should be avoided in patients with known allergies to any of the components of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis. Therefore, consult your doctor before using Trajenta Duo 2.5mg/500mg Tablet.

Is it safe to drink alcohol while I am also taking Trajenta Duo 2.5mg/500mg Tablet?

No, it is not safe to take Trajenta Duo 2.5mg/500mg Tablet with alcohol. Doing so can increase the chances of lactic acidosis, particularly in cases of fasting, malnutrition, or kidney dysfunction. However, if you are not sure, consult your doctor.

Can the use of Trajenta Duo 2.5mg/500mg Tablet cause hypoglycemia?

The use of Trajenta Duo 2.5mg/500mg Tablet does not usually cause hypoglycemia (low blood sugar level) on its own. However, it may occur if there is not enough calorie intake while using this medicine. Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. The symptoms are more likely to be noticed if you miss or delay your food, drink alcohol, overexercise, or take any other antidiabetic medicine along with it. Hence, regular monitoring of blood sugar levels is important. It is recommended to always carry glucose tablets, honey, or fruit juice with you.

Can the use of Trajenta Duo 2.5mg/500mg Tablet lead to vitamin B12 deficiency?

Yes, long-term use of Trajenta Duo 2.5mg/500mg Tablet can cause vitamin B12 deficiency as it interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems. These may further cause a tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status, and difficulty in maintaining balance (ataxia). Consult your doctor if you experience these symptoms. Your doctor may advise monitoring of B12 levels and prescribe a vitamin B12 supplement if required.

What are the instructions for the storage and disposal of Trajenta Duo 2.5mg/500mg Tablet?

Keep this medicine tightly closed in the packet or the container it came in. Store it according to the instructions mentioned on the pack or label. Dispose the unused medicine. Make sure it is not consumed by pets, children, or other people.

Fact Box

Habit Forming

Therapeutic Class

ANTI DIABETIC

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

User feedback

Patients taking Trajenta Duo 2.5mg/500mg Tablet

Twice A Day

60%

Once A Day

40%

What are you using Trajenta Duo Tablet for?

Type 2 diabetes mellitus

97%

Others

How much was the improvement?

Excellent

43%

Average

38%

Poor

20%

What were the side-effects while using Trajenta Duo 2.5mg/500mg Tablet?

Headache

27%

Vomiting

20%

Nausea

20%

Upset stomach

13%

Diarrhea

13%

How do you take Trajenta Duo Tablet?

Empty stomach

50%

With or without food

33%

With food

17%

Please rate Trajenta Duo 2.5mg/500mg Tablet on price

Expensive

58%

Average

30%

Not Expensive

12%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Boehringer Ingelheim
Address: 1102, Hallmark Business Plaza, 11th Floor, Gurunanak Hospital Road, Near Gurunanak Hospital, Bandra (East), Mumbai 400051

Vendor Details

Country of origin: Germany
A licensed vendor partner from your nearest location will deliver Trajenta Duo 2.5mg/500mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Trajenta Duo 2.5mg/500mg Tablet

Cash on delivery

Free Return

Expiry after

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Trajenta Duo Tablet

Benefits of Trajenta Duo Tablet

Side effects of Trajenta Duo Tablet

How to use Trajenta Duo Tablet

How Trajenta Duo Tablet works

All substitutes for Trajenta Duo 2.5mg/500mg Tablet

LiNaxa M 2.5/500 Tablet

Ondero Met 2.5mg/500mg Tablet

Dynaglipt LM 500mg/2.5mg Tablet

Juslina M 500mg/2.5mg Tablet

Linares M Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

Does the use of Trajenta Duo 2.5mg/500mg Tablet cause lactic acidosis?

What are the possible side effects of Trajenta Duo 2.5mg/500mg Tablet?

Are there any specific conditions in which Trajenta Duo 2.5mg/500mg Tablet should not be taken?

Is it safe to drink alcohol while I am also taking Trajenta Duo 2.5mg/500mg Tablet?

Can the use of Trajenta Duo 2.5mg/500mg Tablet cause hypoglycemia?

Can the use of Trajenta Duo 2.5mg/500mg Tablet lead to vitamin B12 deficiency?

What are the instructions for the storage and disposal of Trajenta Duo 2.5mg/500mg Tablet?

Fact Box

Habit Forming

Therapeutic Class

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

User feedback

Patients taking Trajenta Duo 2.5mg/500mg Tablet

What are you using Trajenta Duo Tablet for?

How much was the improvement?

What were the side-effects while using Trajenta Duo 2.5mg/500mg Tablet?

How do you take Trajenta Duo Tablet?

Please rate Trajenta Duo 2.5mg/500mg Tablet on price

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Disclaimer

Marketer details

Vendor Details

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