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    Metformin + Linagliptin

    Information about Metformin + Linagliptin

    Metformin + linagliptin uses

    Metformin+Linagliptin is used in the treatment of type 2 diabetes mellitus.

    How metformin + linagliptin works

    This is a combination of two antidiabetic medicines: Metformin and Linagliptin. Metformin is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Linagliptin is a DPP-4 inhibitor which works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces both fasting and postmeal sugar levels. Together, they provide better control of blood sugar.

    Common side effects of metformin + linagliptin

    Diarrhea, Nausea, Vomiting, Stomach upset, Headache, Nasal congestion, Sore throat, Respiratory tract infection, Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
    Content Details
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    Written By
    Dr. Betina Chandolia
    MDS, BDS
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    Reviewed By
    Dr. Lalit Kanodia
    MD (Pharmacology), MBBS
    Last updated on:
    03 Dec 2019 | 04:56 PM (IST)
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    Available Medicine for Metformin + Linagliptin

    Expert advice for Metformin + Linagliptin

    • Metformin + Linagliptin should be taken with food to lower the chances of having an upset stomach.
    • Take it in addition to regular exercise and healthy diet to lower levels of blood sugar.
    • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines. 
    • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
    • Monitor your blood sugar level regularly while you are taking this medicine. 
    • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.
    • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Metformin + Linagliptin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

    Frequently asked questions for Metformin + Linagliptin

    Metformin + Linagliptin

    Q. What is Metformin+Linagliptin?

    Metformin+Linagliptin is a combination of two medicines: Metformin and Linagliptin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. Linagliptin inhibits the enzyme DPP4 and increases the release of insulin from the pancreas. This combination is not indicated for the patients below 18 years of age.

    Q. What are the possible side effects of Metformin+Linagliptin?

    The use of Metformin+Linagliptin is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache, and upper respiratory tract infection. Its use can also lead to serious but rare side effect like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.

    Q. Are there any specific conditions in which Metformin+Linagliptin should not be taken?

    The use of Metformin+Linagliptin should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine is also considered to be harmful for patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis or diabetic ketoacidosis.

    Q. Is it safe to take alcohol while I am also taking Metformin+Linagliptin?

    No, it is not safe to take Metformin+Linagliptin along with alcohol. It can increase the chances of lactic acidosis, particularly in cases of fasting, malnutrition or hepatic impairment.

    Q. Can the use of Metformin+Linagliptin cause hypoglycemia?

    The use of Metformin+Linagliptin does not usually cause hypoglycemia (low blood sugar level) alone. However, hypoglycemia may occur if there is insufficient supplementation of calories (like missing meals) while taking this medicine. Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. It happens more often if you miss or delay your meal, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always carry glucose tablets, honey or fruit juice with you.

    Q. Can the use of Metformin+Linagliptin cause lactic acidosis?

    Yes, the use of Metformin+Linagliptin can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Metformin+Linagliptin and immediately consult your doctor.

    Q. Can the use of Metformin+Linagliptin lead to Vitamin B12 deficiency?

    Yes, the use of Metformin+Linagliptin can cause vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). Consult your doctor if you experience these symptoms. Your doctor may advise monitoring of B12 levels and supplementation with B12 if required.

    Q. What are the instructions for the storage and disposal of Metformin+Linagliptin?

    Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

    Content on this page was last updated on 03 December, 2019, by Dr. Varun Gupta (MD Pharmacology)