Metformin + Linagliptin

Information about Metformin + Linagliptin

Metformin + Linagliptin Uses

Metformin+Linagliptin is used in the treatment of type 2 diabetes mellitus.

How Metformin + Linagliptin works

Metformin + Linagliptin is a combination of two antidiabetic medicines: Metformin and Linagliptin. Metformin is an antidiabetic medication (biguanide). It works by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's sensitivity to insulin. Linagliptin is a DPP-4 inhibitor which works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces both fasting and postmeal sugar levels. Together, they provide better control of blood sugar.

Common side effects of Metformin + Linagliptin

Diarrhea, Nausea, Vomiting, Upset stomach, Headache, Nasal congestion (stuffy nose), Sore throat, Respiratory tract infection, Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
Written By
Reviewed By
MD (Pharmacology), MBBS
Last updated:
25 Jun 2020 | 09:11 AM (UTC)
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Available Medicine for Metformin + Linagliptin

Trajenta DuoBoehringer Ingelheim
261 to ₹2713 variant(s)
Ondero MetLupin Ltd
261 to ₹2713 variant(s)

Expert advice for Metformin + Linagliptin

  • Metformin + Linagliptin should be taken with food to lower the chances of having an upset stomach.
  • Take it in addition to regular exercise and a healthy diet to lower the levels of blood sugar.
  • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines. 
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • Inform your doctor about your diabetes treatment if you are due to have any surgery under a general anaesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting or stomach pain as Metformin + Linagliptin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Frequently asked questions for Metformin + Linagliptin

Metformin + Linagliptin

Q. Can the use of Metformin+Linagliptin cause lactic acidosis?

Yes, the use of Metformin+Linagliptin can lead to lactic acidosis which is also known as MALA (Metformin-associated lactic acidosis). It is caused by increased levels of lactic acid in the blood. It is a very rare side effect associated with the use of metformin and therefore it is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Metformin+Linagliptin and immediately consult your doctor.

Q. What are the possible side effects of Metformin+Linagliptin?

The use of Metformin+Linagliptin may cause some common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. It can also lead to a serious but rare side effect known as lactic acidosis. Additionally, its long-term use can also lead to vitamin B12 deficiency.

Q. Are there any specific conditions in which Metformin+Linagliptin should not be taken?

The use of Metformin+Linagliptin should be avoided in patients with known allergy to any of the components of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis or diabetic ketoacidosis. Therefore, consult your doctor before using Metformin+Linagliptin.

Q. Is it safe to take alcohol while I am also taking Metformin+Linagliptin?

No, it is not safe to take Metformin+Linagliptin along with alcohol. Doing so can increase the chances of lactic acidosis, particularly in cases of fasting, malnutrition or kidney dysfunction. However, if you are not sure, consult your doctor.

Q. What are the instructions for the storage and disposal of Metformin+Linagliptin?

Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Metformin+Linagliptin cause hypoglycemia?

The use of Metformin+Linagliptin does not usually cause hypoglycemia (low blood sugar level) on its own. But, it could occur if there is insufficient supplementation of calories while taking this medicine. Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. The symptoms are more likely to be noticed if you miss or delay your food, drink alcohol, over-exercise or take any other antidiabetic medicine along with it. Hence, regular monitoring of blood sugar level is important. It is recommended to always carry glucose tablets, honey or fruit juice with you.

Q. Can the use of Metformin+Linagliptin lead to vitamin B12 deficiency?

Yes, long-term use of Metformin+Linagliptin can cause vitamin B12 deficiency as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems. These may further cause a tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). Consult your doctor if you experience these symptoms. Your doctor may advise monitoring of B12 levels and prescribe a vitamin B12 supplement if required.


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