Product introduction
Topocan 2.5mg Injection is used in the treatment of ovarian cancer. It shows its working by stopping or slowing down the growth of cancer cells.
Topocan 2.5mg Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include tiredness, vomiting, weakness, nausea, and abdominal pain. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, chills, sore throat, and severe diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Topocan Injection
Benefits of Topocan Injection
In Ovarian cancer
Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Topocan 2.5mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. Consult your doctor to know about ways that can help you avoid these side effects.
Side effects of Topocan Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Topocan
- Tiredness
- Vomiting
- Weakness
- Nausea
- Abdominal pain
- Indigestion
- Decreased white blood cell count
- Decreased blood cells (red cells, white cells, and platelets)
- Diarrhea
- Injection site reactions (pain, swelling, redness)
How to use Topocan Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Topocan Injection works
Topocan 2.5mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Topocan 2.5mg Injection. Please consult your doctor.
Pregnancy
UNSAFE
Topocan 2.5mg Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding
UNSAFE
Topocan 2.5mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Topocan 2.5mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Topocan 2.5mg Injection can make you feel tired and this may affect your ability to drive.
Topocan 2.5mg Injection can make you feel tired and this may affect your ability to drive.
Kidney
CAUTION
Topocan 2.5mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Topocan 2.5mg Injection is not recommended in patients with end-stage kidney disease.
Use of Topocan 2.5mg Injection is not recommended in patients with end-stage kidney disease.
Liver
SAFE IF PRESCRIBED
Topocan 2.5mg Injection is safe to use in patients with liver disease. No dose adjustment is recommended.
What if you forget to take Topocan Injection?
If you miss a dose of Topocan 2.5mg Injection, contact your doctor as soon as possible. They will advise you on how to proceed, which may include rescheduling the missed dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Topocan 2.5mg Injection
₹4270/Injection
Topotec 2.5mg Injection
United Biotech Pvt Ltd
₹5604/injection
20% costlier
Quick tips
- Topocan 2.5mg Injection helps treat ovarian cancer.
- It is given by a drip into a vein (intravenous infusion).
- Do not drive or operate machinery as Topocan 2.5mg Injection may cause tiredness, drowsiness or weakness.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Fact Box
Chemical Class
Camptothecins
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Topoisomerase Inhibitors
Interaction with drugs
Taking Topocan with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Avoid Filgrastim within 24 hours before and 24 hours after the last dose of Topotecan.
Concomitant use can lower white blood cell count for a longer time.
Avoid Pegfilgrastim within 24 hours before and 24 hours after the last dose of Topotecan.
Concomitant use can lower white blood cell count for a longer time.
Avoid Sargramostim within 24 hours before and 24 hours after the last dose of Topotecan.
Concomitant use can lower white blood cell count for a longer time.
Avoid Lenograstim within 24 hours before and 24 hours after the last dose of Topotecan.
Concomitant use can lower white blood cell count for a longer time.
Avoid Molgramostim within 24 hours before and 24 hours after the last dose of Topotecan.
Concomitant use can lower white blood cell count for a longer time.
FAQs
How often is Topocan 2.5mg Injection given?
Generally Topocan 2.5mg Injection treatment is for 4 cycles of 21 day each, patient is given Topocan 2.5mg Injection for first 5 days of each cycle.
Does Topocan 2.5mg Injection cause hair loss?
Yes, Topocan 2.5mg Injection may cause temporary hair loss.
Does Topocan 2.5mg Injection cause flare reaction?
Yes, Topocan 2.5mg Injection may cause flare reaction.
How long does Topocan 2.5mg Injection take to work?
Topocan 2.5mg Injection may start its action once the infusion is started, however, the complete effect may be assessed only after completion of 4 cycles.
Is Topocan 2.5mg Injection a vesicant?
Topocan 2.5mg Injection is a vesicant (irritant).
Is Topocan 2.5mg Injection effective?
Yes Topocan 2.5mg Injection is effective if used at prescribed doses for the prescribed duration as advised by your doctor.
What is Topocan 2.5mg Injection chemotherapy?
It is a treatment therapy that includes Topocan 2.5mg Injection with or without combination of other drugs in treatment of cancer (Usually ovarian or lung cancer).
How is Topocan 2.5mg Injection administered?
Topocan 2.5mg Injection is either administered orally as a capsule or as an intravenous Infusion in the arm over a period of 30 min.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1711-12.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 951.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1383.
- Topotecan hydrochloride. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 1996 [revised 23 Apr. 2018]. [Accessed 24 Jan. 2019] (online) Available from:
- Topotecan. Unterach, Austria: Ebewe Pharma; 1996 [revised Feb. 2014]. [Accessed 27 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topotecan. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:
Marketer details
Name: Venus Remedies Ltd
Address: SCO 857, Cabin No. 10, 2nd Floor, NAC, Manimajra, Chandigarh (U.T.), 160101, India
Country of origin: India
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₹4270
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MRP₹4687.5 9% OFF
10.0 ml in 1 vial
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