Thioplan Injection
Prescription Required
Product introduction
Thioplan Injection is used in the treatment of cancers of the brain, breast, lungs, and ovaries. It is used in combination with other cancer medicine during hematopoietic progenitor cell transplantation (HPCT). It may be also used to treat other conditions, as determined by the doctor.
Thioplan Injection is generally given under the supervision of a healthcare professional. Your doctor will decide the dose and duration of the treatment based on the severity of your condition and what you are being treated for. It may take several weeks or months for you to see or feel the benefits but do not stop getting the injection unless your doctor tells you to.
The most common side effects of this medicine include decreased white blood count, anemia, low blood platelets, increased liver enzymes, increased bilirubin in the blood, mucosal inflammation, hemorrhage, diarrhea, blood in urine, and rash. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidneys, liver, and heart function during treatment with this medicine.
Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Thioplan Injection is generally given under the supervision of a healthcare professional. Your doctor will decide the dose and duration of the treatment based on the severity of your condition and what you are being treated for. It may take several weeks or months for you to see or feel the benefits but do not stop getting the injection unless your doctor tells you to.
The most common side effects of this medicine include decreased white blood count, anemia, low blood platelets, increased liver enzymes, increased bilirubin in the blood, mucosal inflammation, hemorrhage, diarrhea, blood in urine, and rash. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidneys, liver, and heart function during treatment with this medicine.
Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Thioplan Powder for Injection
Benefits of Thioplan Powder for Injection
In Non-small cell lung cancer
Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Thioplan Injection helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
In Ovarian cancer
Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Thioplan Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. So, you should discuss the risks and benefits with your doctor.
Side effects of Thioplan Powder for Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Thioplan
- Decreased white blood cell count (neutrophils)
- Anemia (low number of red blood cells)
- Low blood platelets
- Increased liver enzymes
- Increased bilirubin in the blood
- Mucosal inflammation
- Hemorrhage
- Rash
- Diarrhea
- Blood in urine
How to use Thioplan Powder for Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Thioplan Powder for Injection works
Thioplan Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Thioplan Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Thioplan Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
Thioplan Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Thioplan Injection may cause side effects which could affect your ability to drive.
It is likely that certain adverse events of Thioplan Injection are dizziness, headache, and blurred vision which could affect your ability to drive.
It is likely that certain adverse events of Thioplan Injection are dizziness, headache, and blurred vision which could affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Thioplan Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Thioplan Injection may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Thioplan Injection should be used with caution in patients with liver disease. Dose adjustment of Thioplan Injection may be needed. Please consult your doctor.
Regular monitoring of liver function tests may be advised while you are taking this medicine.
Regular monitoring of liver function tests may be advised while you are taking this medicine.
What if you forget to take Thioplan Powder for Injection?
If you miss a dose of Thioplan Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Thioplan Injection is given as an intravenous infusion (IV infusion) under the supervisión of a doctor.
- Do not skip any dose and complete the course as suggested by your doctor.
- Use an effective method of birth control to avoid pregnancy while taking this medication.
- Your doctor may get regular blood tests done to monitor your blood cell count, platelet count and liver function.
- It makes you feel dizzy. Do not drive or operate machinery until you know how it affects you.
Fact Box
Chemical Class
Thiophosphoric Acids Derivatives
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Alkylating agent
Interaction with drugs
Taking Thioplan with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytot
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Thiotepa from 1 day before until 1 day after taking Molgramostim. Plea
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Thiotepa from 1 day before until 1 day after taking Sargramostim. Plea
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Thiotepa from 14 days before until 24 days after taking Pegfilgrastim.
Concomitant use may increase the risk of opportunistic infections.
Do not consume Natalizumab with Thiotepa.
Patient concerns
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1685.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1355-56.
- Thiotepa. Lugano, Switzerland: ADIENNE SA; 1959 [revised Jan. 2017]. [Accessed 27 Mar. 2019] (online) Available from:
- Drugs.com. Thiotepa Pregnancy and Breastfeeding Warnings. [Accessed 27 Mar. 2019] (online) Available from:
Marketer details
Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Country of origin: India
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