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Tepapro Injection 1
Tepapro Injection 2
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Tepapro Injection

Thiotepa (15mg)
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Tepapro Injection is used in the treatment of cancers of the brain, breast, lungs, and ovaries. It is used in combination with other cancer medicine during hematopoietic progenitor cell transplantation (HPCT). It may be also used to treat other conditions, as determined by the doctor.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 31 Aug 2026 | 01:28 PM (IST)
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General Information

The content is shown in English
Tepapro Injection 1
Tepapro Injection 2

Product introduction

Tepapro Injection is generally given under the supervision of a healthcare professional. Your doctor will decide the dose and duration of the treatment based on the severity of your condition and what you are being treated for. It may take several weeks or months for you to see or feel the benefits but do not stop getting the injection unless your doctor tells you to.

The most common side effects of this medicine include decreased white blood count, anemia, low blood platelets, increased liver enzymes, increased bilirubin in the blood, mucosal inflammation, hemorrhage, diarrhea, blood in urine, and rash. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidneys, liver, and heart function during treatment with this medicine.

Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Benefits of Tepapro Injection

Ovarian cancer
Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Tepapro Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. So, you should discuss the risks and benefits with your doctor.
Non-small cell lung cancer
Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Tepapro Injection helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Tepapro Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tepapro
  • Anemia (low number of red blood cells)
  • Low blood platelets
  • Decreased white blood cell count (neutrophils)
  • Increased liver enzymes
  • Increased bilirubin in the blood
  • Mucosal inflammation
  • Hemorrhage
  • Rash
  • Diarrhea
  • Blood in urine

How to use Tepapro Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Tepapro Injection works

Tepapro Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

All substitutes for Tepapro Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Tepapro Injection is given as an intravenous infusion (IV infusion) under the supervisión of a doctor.
  • Do not skip any dose and complete the course as suggested by your doctor.
  • Use an effective method of birth control to avoid pregnancy while taking this medication.
  • Your doctor may get regular blood tests done to monitor your blood cell count, platelet count and liver function.
  • It makes you feel dizzy. Do not drive or operate machinery until you know how it affects you.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Tepapro Injection. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Tepapro Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Tepapro Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Tepapro Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
It is likely that certain adverse events of Tepapro Injection are dizziness, headache, and blurred vision which could affect your ability to drive.
Kidney

Kidney

CAUTION
Tepapro Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Tepapro Injection should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Regular monitoring of liver function tests may be advised while you are taking this medicine.
All

Interaction with drugs

Taking Tepapro with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Pegfilgrastim (Injection Route)

Do not consume Thiotepa from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor.
Life-threatening

Sargramostim (Injection Route)

Do not consume Thiotepa from 1 day before until 1 day after taking Sargramostim. Please consult your doctor.
Life-threatening

Lenograstim (Injection Route)

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy.
Life-threatening

Molgramostim (Injection Route)

Do not consume Thiotepa from 1 day before until 1 day after taking Molgramostim. Please consult your doctor.
Life-threatening

Natalizumab (Injection Route)

Do not consume Natalizumab with Thiotepa.

Frequently asked questions

Your doctor may prescribe Tepapro Injection to treat certain types of cancer. It may also be used as part of a conditioning regimen before stem cell transplantation. Thiotepa works by damaging the genetic material of rapidly dividing cells, which helps slow or stop the growth of cancer cells.
Tepapro Injection contains Thiotepa, an anticancer medicine that interferes with the DNA of cancer cells. This prevents the cells from growing and multiplying normally, leading to their destruction. Because it affects rapidly dividing cells, it can also impact some healthy cells, which is why regular monitoring is needed during treatment.
Yes, Tepapro Injection is a chemotherapy medicine. It belongs to a group of medicines known as alkylating agents. Your doctor may prescribe it alone or in combination with other anticancer medicines depending on your condition and treatment goals.
Your doctor may prescribe Tepapro Injection for certain cancers and as part of treatment before stem cell transplantation. The exact use depends on the type of cancer, your overall health, and your treatment plan. Your doctor will determine whether this medicine is appropriate for your condition.
Before a stem cell transplant, your doctor may prescribe Tepapro Injection along with other medicines to help destroy remaining cancer cells and prepare the bone marrow for transplantation. This process helps create space for the new stem cells and may improve the chances of successful engraftment.
The duration of treatment varies depending on the condition being treated, the treatment protocol, and how well your body responds. Some individuals may receive it for a short period as part of a transplant regimen, while others may receive it according to a specific chemotherapy schedule determined by their doctor.
Cancer treatment outcomes vary from person to person. While Tepapro Injection can help control or eliminate cancer cells, some cancers may return after treatment. Regular follow-up visits, scans, and blood tests help your doctor monitor your response and detect any recurrence as early as possible.
Yes. Tepapro Injection can reduce the number of white blood cells that help protect your body from infections. During treatment, you may become more susceptible to infections. Contact your doctor promptly if you develop fever, chills, sore throat, cough, or any other signs of infection.
Regular blood tests help your doctor monitor blood cell counts and assess how your body is responding to treatment. Thiotepa can affect white blood cells, red blood cells, and platelets. Monitoring allows your doctor to identify potential problems early and make any necessary adjustments to treatment.
Contact your doctor immediately if you develop a severe skin rash, unusual bruising, bleeding, or blood in your urine. These symptoms may indicate a serious side effect that requires prompt medical attention. Do not ignore persistent or worsening symptoms during treatment.
Yes. Tepapro Injection may reduce platelet levels, which can increase the risk of bruising and bleeding. Inform your doctor if you notice unusual bleeding from the gums, nosebleeds, blood in the urine, black stools, or easy bruising. Regular blood tests help monitor this risk.
Tell your doctor about all medicines, supplements, and herbal products you are using before starting treatment. Some medicines, including those that affect blood cell production or immune function, may interact with Tepapro Injection. Your doctor can determine whether any changes to your treatment plan are needed.
Thiotepa may affect fertility in both men and women. If you plan to have children in the future, discuss fertility preservation options with your doctor before starting treatment. Your doctor can provide guidance based on your age, treatment plan, and individual circumstances.
Tepapro Injection can harm an unborn baby if pregnancy occurs during treatment. Both men and women should use effective contraception during treatment and for the period recommended by their doctor after treatment ends. Speak with your doctor about suitable contraceptive methods and family planning considerations.
Contact your doctor immediately if you develop fever, signs of infection, unusual bleeding, severe skin reactions, breathing difficulties, persistent vomiting, extreme tiredness, or any other unexpected symptoms. Prompt medical attention can help manage potential complications and improve treatment safety.

Fact Box

Chemical Class

Organic thiophosphoric acid derivative

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1685.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1355-56.
  3. Thiotepa. Lugano, Switzerland: ADIENNE SA; 1959 [revised Jan. 2017]. [Accessed 27 Mar. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Emcure Pharmaceuticals Ltd
Address: 255/2, Hinjawadi, Pune - 411057, India / Godown A, Gat No. 408 and 410, Vill: Urse, Tal: Maval, Pune-410 506, Maharashtra, India.

Vendor Details

Country of origin: India
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