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Tapendol 50mg Tablet

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 14 Apr 2026 | 12:43 PM (IST)
Tapendol 50mg Tablet is a medicine used to treat moderate to severe acute pain in adults. It is used to treat many conditions such as headache, fever, period pain, toothache, and colds. It effectively alleviates pain when other treatments fail to relieve your pain.
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General Information

Contains

Tapentadol (50mg)

Marketer

Unimarck Healthcare Ltd

Storage

Store below 30°C
The content is shown in English
Tapendol 50mg Tablet image
Tapendol 50mg Tablet image

Product introduction

Take Tapendol 50mg Tablet exactly as prescribed by your doctor and follow the recommended dose and schedule carefully. Do not take more than advised or use it for longer than prescribed, as it may lead to dependence. Try to take it at the same time each day to maintain consistent pain relief. Do not suddenly stop the medicine without consulting your doctor, as it may cause withdrawal symptoms.


Tapendol 50mg Tablet may cause some common side effects such as nausea, dizziness, vomiting, and somnolence (sleepiness). These effects are usually mild to moderate and may improve as your body adjusts to the medicine. However, if they persist or become bothersome, consult your doctor.


Use Tapendol 50mg Tablet with caution in individuals with respiratory disorders, head injury, liver or kidney impairment, or a history of substance abuse. It may cause drowsiness, so avoid driving or operating machinery until you know how it affects you. Avoid alcohol and other sedative medicines, as they can increase the risk of serious side effects. It should not be used in patients with severe breathing problems. Always inform your doctor about all ongoing medications and medical conditions before starting treatment.

Uses of Tapendol Tablet

  • Moderate to severe pain

Benefits of Tapendol Tablet

Moderate to severe pain
Tapendol 50mg Tablet helps to relieve moderate to severe pain like toothache, headache, or in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis.
Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Tapendol Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tapendol
  • Sleepiness
  • Nausea
  • Vomiting
  • Dizziness

How to use Tapendol Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tapendol 50mg Tablet may be taken with or without food.

How Tapendol Tablet works

Tapendol 50mg Tablet works by changing how the brain and nerves respond to pain. It reduces pain signals by acting on opioid receptors and also enhances the levels of a natural chemical called norepinephrine, which helps block pain messages in the nervous system. Together, these actions help provide effective relief from moderate to severe pain.

Quick tips

  • Tapendol 50mg Tablet is a strong painkiller which is used in the treatment of moderate to severe pain when other treatments do not treat your pain well enough or you cannot tolerate them.
  • The addiction / habit-forming potential of Tapendol 50mg Tablet is very high. Take exactly as prescribed by your doctor.
  • Use caution while driving or doing anything that requires concentration as Tapendol 50mg Tablet can cause dizziness and sleepiness.
  • While taking this medication, avoid alcohol in all forms including beer, wine, aftershave lotions, mouthwash, vinegar, certain desserts, colognes, and liquid medications.
  • Inform your doctor if you have asthma, liver, kidney or pancreatic disease, or are severely constipated.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Tapendol 50mg Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Tapendol 50mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Tapendol 50mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Tapendol 50mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
If you feel drowsy, dizzy, have blurred vision or a slow reaction time while taking Tapendol 50mg Tablet, then do not drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Tapendol 50mg Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
Liver

Liver

CAUTION
Tapendol 50mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Tapendol 50mg Tablet is not recommended in patients with severe kidney disease.

Interaction with drugs

Taking Tapendol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Naltrexone (Oral Route)

Do not consume Naltrexone with Tapentadol; watch out for symptoms such as breathlessness, increased heart rate, or headache. Naltrexone may reduce efficacy of Tapentadol.
Severe

Alprazolam (Oral Route)

If concurrent use is essential, watch out for symptoms of Alprazolam side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Alprazolam as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.
Severe

Alprazolam (Injection Route)

If concurrent use is essential, watch out for symptoms of Alprazolam side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Alprazolam as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.
Severe

Chlordiazepoxide (Oral Route)

If concurrent use is essential, watch out for symptoms of Chlordiazepoxide side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Chlordiazepoxide as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.
Severe

Clobazam (Oral Route)

If concurrent use is essential, watch out for symptoms of Clobazam side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Clobazam as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.

Frequently asked questions

Yes. If you take Tapendol 50mg Tablet too much or for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose. So it is important to take it only as directed by your doctor.
Symptoms of an overdose include difficult, fast or slow, or troubled breathing, or pale or blue lips, fingernails, or skin. Call your doctor right away if you notice these symptoms.
It is advisable to avoid alcohol, driving, or indulging in any hazardous activity while taking this medicine.
There are many alternatives to this medicine. However, you should always check with your doctor or pharmacist before making any change to the dosage or type of medicine you take.
Since Tapendol 50mg Tablet is an opioid medicine, it's important you dispose of any unwanted medicine safely as it can lead to inappropriate use. Simply remove the medicine from their original packet and mix them with something undesirable, such as used coffee grounds, dirt, or cat/dog litter. This makes the medicine less appealing to children and pets and unrecognizable to someone who might intentionally go through the trash looking for drugs. After this put the mixture in something you can close (a re-sealable zipper storage bag to prevent the drug from leaking or spilling out. Finally, throw the bag in the garbage.

Fact Box

Chemical Class

Phenylpropanes

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

μ-Opioid Receptor & Norepinephrine Reuptake Inhibitors (NRIs)

References

  1. Schumacher MA, Basbaum AI, Way WL. Opioids Analgesics & Antagonists. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 547.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1315
  3. Tapentadol. Stockley Park East Uxbridge: Grünenthal Ltd.; 2011 [revised 5 Nov. 2018]. [Accessed 02 Apr. 2019] (online) Available from:
  4. Tapentadol. Gurabo, PR: Janssen Ortho, LLC; 2008 [revised Oct. 2013]. [Accessed 02 Apr. 2019] (online) Available from:
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:
  6. Tapentadol [Prescribing Information]. Stoughton, MA: Collegium Pharmaceutical, Inc.; 2023. [Accessed 20 Feb. 2024] (online) Available from:
  7. Apentadol hydrochloride. Laurelton, NY: Epic Pharma, LLC.; 2026. [Accessed 14 Apr. 2026] (online). Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Unimarck Healthcare Ltd
Address: 128, HPSIDC . Inds. Area , baddi -173205(H.P)

Vendor Details

Country of origin: India

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