Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Sakshi Jain

MS, BDS

Reviewed By

Dr. Rajeev Sharma

MBA, MBBS

Last updated

24 Sep 2025 | 05:47 PM (IST)

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Sitaxa EM 25+100+1000 Tablet ER

Prescription Required

Marketer

Torrent Pharmaceuticals Ltd

SALT COMPOSITION

Sitagliptin (100mg) + Metformin (1000mg) + Empagliflozin (25mg)

Storage

Store below 30°C

View available alternative with same salt composition

Click here to view all substitutes

Product introduction

Sitaxa EM 25+100+1000 Tablet ER is a medicine used to treat type 2 diabetes mellitus. It works by lowering sugar production and improving insulin action. It also removes excess glucose, helping maintain better blood sugar control.

Sitaxa EM 25+100+1000 Tablet ER should be taken exactly as prescribed. It can be taken with or without food. Regular dosing is important to keep blood sugar under control. Do not skip doses or stop without medical advice, as this may cause uncontrolled diabetes. If a dose is missed, take it as soon as remembered, but do not double the dose.

The most common side effects include hypoglycaemia, headache, thirst, constipation, increased urination, and urinary tract infection. Some patients may experience low blood sugar when taken with insulin or sulfonylureas. Rarely, dehydration, excessive thirst, or ketoacidosis may occur.

Sitaxa EM 25+100+1000 Tablet ER should not be used in patients with severe kidney impairment, end-stage renal disease, or dialysis. It is contraindicated in people with metabolic acidosis or diabetic ketoacidosis. Caution is required in those with a history of frequent urinary or genital infections, dehydration, heart failure, or low blood pressure. It should not be used during pregnancy or breastfeeding unless clearly needed. Regular monitoring of kidney function, blood sugar, and hydration status is advised.

Uses of Sitaxa EM Tablet ER

Treatment of Type 2 diabetes mellitus

Benefits of Sitaxa EM Tablet ER

In Treatment of Type 2 diabetes mellitus

Type 2 diabetes mellitus is a condition where the body cannot manage blood sugar effectively, leading to persistently high glucose levels. Sitaxa EM 25+100+1000 Tablet ER helps lower and control blood sugar through complementary actions that improve how the body handles glucose. It helps to maintain stable blood sugar control, reducing the risk of complications and supporting overall health in people with type 2 diabetes.

Side effects of Sitaxa EM Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sitaxa EM

Hypoglycemia (low blood glucose level)
Headache
Increased thirst
Constipation
Frequent urge to urinate
Urinary tract infection

How to use Sitaxa EM Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sitaxa EM 25+100+1000 Tablet ER may be taken with or without food, but it is better to take it at a fixed time.

How Sitaxa EM Tablet ER works

Sitaxa EM 25+100+1000 Tablet ER is a combination of sitagliptin, metformin, and empagliflozin. Metformin decreases glucose production in the liver and improves the body’s response to insulin. Sitagliptin increases insulin release and lowers glucose production after meals by improving natural hormone activity. Empagliflozin helps remove excess glucose through urine by blocking its reabsorption in the kidneys. When combined, these actions complement each other, reducing sugar production, improving insulin action, and promoting glucose elimination. This multi-target approach provides stronger, more balanced blood sugar control and helps lower the risk of long-term complications in type 2 diabetes.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Sitaxa EM 25+100+1000 Tablet ER.

Pregnancy

CONSULT YOUR DOCTOR

Sitaxa EM 25+100+1000 Tablet ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Sitaxa EM 25+100+1000 Tablet ER is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

CAUTION

Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.

Kidney

CAUTION

Sitaxa EM 25+100+1000 Tablet ER should be used with caution in patients with severe kidney disease. Dose adjustment of Sitaxa EM 25+100+1000 Tablet ER may be needed. Please consult your doctor.

Liver

CAUTION

Sitaxa EM 25+100+1000 Tablet ER should be used with caution in patients with liver disease. Dose adjustment of Sitaxa EM 25+100+1000 Tablet ER may be needed. Please consult your doctor.

What if you forget to take Sitaxa EM Tablet ER?

If you miss a dose of Sitaxa EM 25+100+1000 Tablet ER, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Sitaxa EM 25+100+1000 Tablet ER

₹19.3/Tablet ER

Gibtulio-SM 25/1000 Tablet ER

Lupin Ltd

₹18.9/tablet er

2% cheaper

Quick tips

Stay well hydrated to avoid dehydration and kidney-related problems.
Maintain good personal hygiene to reduce the risk of urinary or genital infections.
Monitor blood sugar levels regularly and attend follow-up checkups.
Inform your doctor immediately if you experience symptoms like extreme thirst, nausea, vomiting, or rapid breathing (possible ketoacidosis).

Fact Box

Habit Forming

Therapeutic Class

ANTI DIABETIC

Patient concerns

Diabetes mellitus type 2 ,thirst

Dr. Sanjay Bhatt

Physician

A person can control his or her sugar levels by doing regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOUR DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but a start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications like kidney or heart problems .online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET

Diabetes mellitus type 2 required only ayurvedic medicine

Dr. Sanjay Bhatt

Physician

Go for allopathic medicine

Any latest discoveris for type 1 mellitus Diabetes?

Dr. Sanjay Bhatt

Physician

Diabetes Ireland is delighted to hear of the Harvard success and congratulate Professor Melton and colleagues on figuring out the complex series of steps necessary to turn stem cells into beta cells. Hopefully, they can negotiate the regulations for mass production so that an abundant supply of beta cells is available an new and innovative methods will be developed to cure/treat Type 1 diabetes. Type I diabetes is an autoimmune condition whereby the body kills off its own beta (insulin producing) cells resulting in the need for daily insulin administration through the skin. Replacing beta cells in the first step towards a cure, but the replaced beta cells need to be protected from the body?s autoimmune response. This means protecting them in a coating or taking drugs to prevent the response (possible worse side effects than diabetes).

How to manage diabetes mellitus

Dr. Sanjay Bhatt

Physician

A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND LOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you souls not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET

Suffering from Diabetes mellitus since 7 years

Dr. Sanjay Bhatt

Physician

What is Sitaxa EM 25+100+1000 Tablet ER used for?

It is used to manage type 2 diabetes mellitus by helping control blood sugar levels when diet and exercise alone are not enough.

What side effects should I watch for?

Common side effects include urinary or genital infections, frequent urination, or diarrhea. Rarely, serious conditions like ketoacidosis or dehydration may occur.

Can I use Sitaxa EM 25+100+1000 Tablet ER with insulin?

Yes, but combining with insulin or sulfonylureas may increase the risk of low blood sugar. Your doctor may adjust doses to reduce this risk.

Is Sitaxa EM 25+100+1000 Tablet ER safe during pregnancy or breastfeeding?

It is not recommended during pregnancy or breastfeeding unless clearly needed. Always consult your doctor before use.

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Empagliflozin, sitagliptin, and metformin hydrochloride [Product Information]. Valsad, Gujarat: Torrent Pharmaceuticals Ltd. [Accessed 27 Aug. 2025] (online) Available from: