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Siphene Tablet

Clomiphene (50mg)

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Siphene Tablet is a medicine used to treat female infertility. It is used in women who are unable to become pregnant, due to ovulation problems or suffering from polycystic ovary syndrome (PCOS).

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 29 Apr 2026 | 01:01 PM (IST)

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by Serum Institute Of India Ltd

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General Information

Storage

Store below 25°C

The content is shown in English

Product introduction

Take Siphene Tablet exactly as prescribed by the doctor. It is usually taken for a few days at the beginning of the menstrual cycle. Regular monitoring, including ultrasound scans or hormone level tests, may be needed to track ovulation. Maintaining a healthy lifestyle, including a balanced diet and regular exercise, can further improve the chances of pregnancy while on this medication.

The most common side effects associated with this medicine are hot flushes (red and warm face), stomach discomfort, breast pain, and visual disturbances. Most of these symptoms are temporary. However, if they persist, consult your doctor as soon as possible.

Inform your doctor before taking Siphene Tablet if you have any issues with the liver, kidney, or heart, and if you are pregnant. Additionally, tell your doctor if you are taking any medicine or supplement before starting Siphene Tablet.

Uses of Siphene Tablet

Female infertility

Benefits of Siphene Tablet

Female infertility
Siphene Tablet helps in the normal development of an egg in a woman’s ovary (female reproductive organ) and stimulates the release of a healthy, matured egg. This helps to treat infertility in women and increases the chance of a successful pregnancy. It is commonly used in women who are taking treatment for ovulation-related issues or polycystic ovary syndrome (PCOS). Take this medicine in the dose and duration prescribed by the doctor.

Side effects of Siphene Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Siphene

Metrorrhagia (menstrual bleeding at irregular intervals)
Nausea
Hot flashes
Breast discomfort
Visual disorder
Vomiting
Bloating
Headache
Enlarged ovary

How to use Siphene Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Siphene Tablet may be taken with or without food.

How Siphene Tablet works

Siphene Tablet is a selective estrogen receptor modulator (SERM) that treats female infertility. It works by promoting the release of reproductive hormones. This helps stimulate the release of eggs from the ovary (ovulation).

All substitutes for Siphene Tablet

For information purposes only. Consult a doctor before taking any medicine.

Fertitrig 50 Tablet

by Leeford Healthcare Ltd

₹7.24/tablet

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Ovagen 50mg Tablet

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Quick tips

Siphene Tablet is not safe for long-term use. Hence, it is advisable not to use it for more than 3 menstrual cycles.
The medicine will cause ovulation after 5-10 days. It is advisable to have regular intercourse during this period.
It may cause blurring of vision. Be cautious while driving or doing anything requiring mental focus.
Inform your doctor if you experience abdominal pain and distention, nausea, vomiting, diarrhea, and weight gain while taking this medicine.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Siphene Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Siphene Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Siphene Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Siphene Tablet may cause temporary visual disturbances. Do not drive until your vision is clear.

Kidney

CAUTION

Siphene Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Siphene Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

What is the Siphene Tablet used for?

Siphene Tablet is used in some women who are unable to become pregnant, due to problem with ovulation (release of an egg) or have a condition called polycystic ovary syndrome (PCOS).

How and in what dose should I take Siphene Tablet?

For best results, take Siphene Tablet strictly as per the advice of your doctor. The number of doses you take each day, and the duration for which you take the medicine depends on the medical problem being treated.

After how many days of Siphene Tablet intake should I have sex to get pregnant?

It is ideal to have sex after 5-10 days of taking Siphene Tablet. However, your doctor may examine you regularly during the treatment and suggest you the best possible days.

For how many cycles can I take Siphene Tablet?

Your treatment with Siphene Tablet may be repeated by the doctor until you get pregnant. However, the treatment can be repeated only for up to 4 menstrual cycles.

What are the common side effects of using Siphene Tablet?

The most common side effects associated with Siphene Tablet are hot flushes (red and warm face), stomach discomfort, and breast pain. Most of these symptoms are temporary. However, if they persist, check with your doctor as soon as possible.

Can I take Siphene Tablet without a doctor’s prescription?

No, Siphene Tablet is a prescription drug. It is not available or sold without a doctor’s prescription

Can I take Siphene Tablet if I have an ovarian cyst?

No, Siphene Tablet should not be taken, if there is a cyst in the ovary. Please consult your doctor before use

Can I take Siphene Tablet with metformin?

Siphene Tablet can be taken with metformin, only if advised by your doctor.

Fact Box

Chemical Class

Stilbenes

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Selective Estrogen Receptor Modulators (SERMs)- Ovulation Stimulants

Related lab tests

Anti Mullerian Hormone

Glycosylated Hemoglobin

Testosterone Total

Thyroid Stimulating Hormone

References

Schimmer BP, Parker KL. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1841-43.
Chrousos GP. The Gonadal Hormones & Inhibitors. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 718-19.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 296-98.
Clomifene citrate [EMC SmPC]. Reading, Berkshire: Sanofi; 2019. [Accessed 30 Jan. 2020] (online) Available from:
Clomiphene citrate [FDA Label]. Bridgewater, NJ: Sanofi-Aventis U.S. LLC; 2012. [Accessed 30 Jan. 2020] (online) Available from:
Clomifene citrate [Package Information Leaflet]. Reading, Berkshire: Sanofi; 2019. [Accessed 30 Jan. 2020] (online) Available from:
CiplaMed. Clomiphene citrate [Prescribing Information]. [Accessed 25 Jul. 2024] (online) Available from:
Clomifene citrate [Summary of Product Characteristics]. Gentilly, France: Sanofi-Aventis France; 2018. [Accessed 05 Mar. 2025] (online) Available from:
Clomiphene citrate [Summary of Product Characteristics]. Alwar, Rajasthan: Gracure Pharmaceuticals Ltd.; 2019. [Accessed 05 Mar. 2025] (online) Available from:

User feedback

Patients taking Siphene Tablet

Once A Day

100%

What are you using Siphene Tablet for?

Female infertility

89%

Others

11%

How much was the improvement?

Poor

47%

Excellent

27%

Average

26%

What were the side-effects while using Siphene Tablet?

No Side Effect

56%

Nausea

12%

Bloating

12%

Vomiting

12%

Headache

How do you take Siphene Tablet?

With food

73%

With or without food

19%

Empty stomach

Please rate Siphene Tablet on price

Expensive

36%

Not Expensive

35%

Average

29%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Serum Institute Of India Ltd
Address: 212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Siphene Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

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Siphene Tablet

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Siphene Tablet

Benefits of Siphene Tablet

Side effects of Siphene Tablet

How to use Siphene Tablet

How Siphene Tablet works

All substitutes for Siphene Tablet

Fertitrig 50 Tablet

Fertomid 50 Tablet

Clofert 50 Tablet

Fertyl Tablet

Ovagen 50mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is the Siphene Tablet used for?

How and in what dose should I take Siphene Tablet?

After how many days of Siphene Tablet intake should I have sex to get pregnant?

For how many cycles can I take Siphene Tablet?

What are the common side effects of using Siphene Tablet?

Can I take Siphene Tablet without a doctor’s prescription?

Can I take Siphene Tablet if I have an ovarian cyst?

Can I take Siphene Tablet with metformin?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Anti Mullerian Hormone

Glycosylated Hemoglobin

Testosterone Total

Thyroid Stimulating Hormone

References

User feedback

Patients taking Siphene Tablet

What are you using Siphene Tablet for?

How much was the improvement?

What were the side-effects while using Siphene Tablet?

How do you take Siphene Tablet?

Please rate Siphene Tablet on price

Want to know more

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Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

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