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Segicool 40 Tablet

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 19 Jan 2026 | 02:50 PM (IST)
Segicool 40 Tablet is used to treat conditions related to excessive stomach acid production, such as gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome. It reduces the amount of acid produced in the stomach and provides relief from symptoms and promotes healing.
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Segicool 40 Tablet
Segicool 40 Tablet
strip of 10 tablets
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General Information

The content is shown in English
Segicool 40 Tablet image
Segicool 40 Tablet image

Product introduction

Segicool 40 Tablet can also be used to prevent stomach ulcers caused by certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs). Take it in the exact dose and duration prescribed by your doctor. It is usually taken on an empty stomach, preferably in the morning or at least 1 hour before a meal. Continue taking the medicine even if your symptoms disappear until the doctor says it is okay to stop. If you are taking this medicine for a long time, your doctor may carry out regular tests to check your levels of magnesium, which can fall with this medicine.


Common side effects include headache, constipation or diarrhea, stomach pain, and nausea. These tend to be mild, but talk to your doctor if they bother you or do not go away. The risk of side effects may increase the longer you take this medicine. You may be more likely to have a broken bone if you take it for a long time. It is best to avoid foods that seem to make your symptoms worse, such as rich, spicy, and fatty foods. Cutting down on caffeinated drinks, such as tea, coffee, and cola, as well as alcohol, may also help.


Segicool 40 Tablet may not be suitable for some people. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have had an allergic reaction to similar medicines in the past, or have osteoporosis. Alcohol does not interfere with the way Segicool 40 Tablet works; however, drinking alcohol makes your stomach produce more acid than normal. This medicine can make you feel dizzy, sleepy, or affect your vision. If this happens, do not drive, cycle, or use machinery or tools until you feel better. This medicine is not usually recommended during pregnancy and breastfeeding.

Uses of Segicool Tablet

Benefits of Segicool Tablet

Acidity
Segicool 40 Tablet helps relieve the discomfort caused by excessive stomach acid, such as burning sensations, sour stomach, or acid regurgitation. By reducing acid production, it soothes the stomach lining and prevents irritation, providing fast and lasting relief. For individuals suffering from frequent acidity, Segicool 40 Tablet improves their quality of life by enabling them to enjoy meals and daily activities without the discomfort and inconvenience of acid-related symptoms.
Gastroesophageal reflux disease (Acid reflux)
Segicool 40 Tablet helps manage GERD by reducing the flow of stomach acid into the esophagus, which causes the burning sensation of heartburn and other acid reflux symptoms. This helps alleviate discomfort, protects the esophagus from long-term damage, and minimizes complications like inflammation or narrowing of the esophagus.
Peptic ulcer disease
In individuals with peptic ulcer disease, Segicool 40 Tablet helps reduce stomach acid levels, which allows the ulcers to heal more effectively and prevents further damage to the stomach lining. It also helps reduce symptoms like pain, nausea, and indigestion. By promoting healing and preventing the recurrence of ulcers, Segicool 40 Tablet improves patients’ comfort and restores normal digestion, improving their overall well-being.
Treatment of Zollinger-Ellison syndrome
Zollinger-Ellison syndrome is a rare disorder where excessive stomach acid production can cause severe symptoms like diarrhea, abdominal pain, and ulcers. Segicool 40 Tablet reduces this overproduction of acid, helping to control symptoms and prevent complications like bleeding ulcers. By managing acid levels effectively, the medicine allows patients to lead a more comfortable and active life without being constantly disrupted by severe digestive symptoms.

Side effects of Segicool Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Segicool
  • Vomiting
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Headache
  • Fundic gland polyps

How to use Segicool Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Segicool 40 Tablet is to be taken on an empty stomach.

How Segicool Tablet works

Segicool 40 Tablet is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

Quick tips

  • Segicool 40 Tablet is best taken 1 hour before a meal, preferably in the morning.
  • Avoid drinking alcohol, smoking cigarettes, and excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, and caffeinated beverages like tea and coffee.
  • Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
  • Inform your doctor if you do not feel better after taking it for 14 days, as you may be suffering from some other problem that needs attention.
  • Long-term use of Segicool 40 Tablet can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Segicool 40 Tablet. Please consult your doctor.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Segicool 40 Tablet is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Segicool 40 Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

SAFE
Segicool 40 Tablet does not usually affect your ability to drive.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Segicool 40 Tablet in patients with kidney disease. Please consult your doctor.
Liver

Liver

CAUTION
Segicool 40 Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Segicool with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Erlotinib (Oral Route)

Do not consume Erlotinib with Esomeprazole. Esomeprazole may reduce blood levels of Erlotinib.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Frequently asked questions

Usually, Segicool 40 Tablet is taken once a day, first thing in the morning. If you take Segicool 40 Tablet twice a day, take 1 dose in the morning and 1 dose in the evening. The tablets should be swallowed whole (remember not be chewed or crushed) and taken at least 1 hour before a meal with some water.
Yes, you can take antacids along with Segicool 40 Tablet. Take it 2 hours before or after you take Segicool 40 Tablet.
Segicool 40 Tablet is usually prescribed for short-term use only. However, if need arises, such as for treating peptic ulcer disease and Zollinger-Ellison syndrome (ZES), Segicool 40 Tablet may be prescribed for a long-term duration as well. Long-term use may carry an increased risk for side effects and must be discussed with the doctor. Please use Segicool 40 Tablet as advised by your doctor and under their supervision.
If you have been taking Segicool 40 Tablet for a long time, stopping it abruptly may lead to increased acid production, thereby worsening your symptoms. Therefore, you must discuss any dose changes or if you wish to come off Segicool 40 Tablet.
If Segicool 40 Tablet is used for more than 3 months, certain long-term side effects may be seen. The most important of these is low magnesium levels in your blood, which may make you feel tired, confused, dizzy, or shaky. You may also have muscle twitches or an irregular heartbeat. If the use is further prolonged for more than a year, you may have an increased risk of bone fractures, stomach infections, and vitamin B12 deficiency. Vitamin B12 deficiency can make you anemic, as a result of which you may feel more tired, weak, or pale. Additionally, you may have palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas), or nerve problems such as numbness, tingling, and problem in walking.
No, alcohol intake is not advised with Segicool 40 Tablet. Alcohol itself does not affect the working of Segicool 40 Tablet, but it can increase the acid production. This may further cause worsening of your symptoms.

Fact Box

Chemical Class

Sulfinylbenzimidazoles

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Proton-Pump Inhibitors
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Selaginella Life Sciences
Address: Show Room NO. 34, G. F, City Square Mall, Sai Road, Baddi, Himachal Pradesh 173205, India

Vendor Details

Country of origin: India
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