Samhep-E 0.5mg Tablet

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 14 Apr 2026 | 04:21 PM (IST)

Entecavir is an antiviral medicine used in the treatment of hepatitis B virus (HBV) infection. It works by inhibiting the replication of the virus, thereby reducing its levels in the body. By suppressing viral replication, it helps to slow down the progression of liver damage.

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General Information

Contains

Entecavir (0.5mg)

Marketer

Samarth Life Sciences Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Samhep-E 0.5mg Tablet should be taken in an empty stomach. Take it in the exact dose and duration prescribed by your doctor. Follow the instructions carefully. Taking it regularly at the right times greatly increases the effectiveness and help improve liver function, and decrease the risk of complications associated with chronic HBV infection. It is not known whether Samhep-E 0.5mg Tablet will reduce your chances of getting liver cancer or liver damage (cirrhosis), which may be caused by chronic HBV infection. Do not miss a dose and keep taking until your doctor tells you it is safe to stop.

Common side effects of this medicine include headache, nausea, and fatigue. These are usually not serious but tell your doctor if they bother you or do not go away. Rarely, some people may experience a skin reaction or liver damage. Your doctor will closely monitor you for these in the initial period of treatment.

Before taking it, tell your doctor if you have any skin problems or kidney disease. While using it, you may need regular blood tests to check your blood counts and liver function. Avoid drinking alcohol as it may increase your risk of liver damage. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex.

Uses of Samhep-E Tablet

Hepatitis B virus (HBV) infection

Benefits of Samhep-E Tablet

Hepatitis B virus (HBV) infection
In patients with chronic hepatitis B virus (HBV) infection, Samhep-E 0.5mg Tablet works by preventing the HBV virus from multiplying in the body. It helps control the infection and makes the immune system work better. This lowers the chances of getting complications and improves the quality of life.

This medicine is always taken in combination with other antiretroviral medicines. It is not a cure and should neither be used to prevent HBV infection. It is important that you take this medicine as prescribed, following the dosage recommended by your doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of the medicine.

Side effects of Samhep-E Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Samhep-E

Headache
Nausea
Vomiting
Fatigue
Stomach pain
Diarrhea

How to use Samhep-E Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Samhep-E 0.5mg Tablet is to be taken on an empty stomach.

How Samhep-E Tablet works

Samhep-E 0.5mg Tablet is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

All substitutes for Samhep-E 0.5mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

You have been prescribed Samhep-E 0.5mg Tablet for the treatment of chronic hepatitis B virus (HBV) infection.
Take it on an empty stomach, at least 2 hours after or before a meal.
Samhep-E 0.5mg Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may still develop infections or other illnesses associated with viral infection while taking this medication.
During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.
You have been prescribed Samhep-E 0.5mg Tablet for the treatment of chronic hepatitis B virus (HBV) infection.
In combination with other medicines, it is used for the treatment of HIV infections.
Take it with food, as this increases the absorption of the medicine into the body.
Samhep-E 0.5mg Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may still develop infections or other illnesses associated with viral infection while taking this medication.
You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Samhep-E 0.5mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Samhep-E 0.5mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Samhep-E 0.5mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Samhep-E 0.5mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Samhep-E 0.5mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

SAFE IF PRESCRIBED

Samhep-E 0.5mg Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.

Interaction with drugs

Taking Samhep-E with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Ciclosporin (Oral Route)

Ciclosporin may raise blood levels of Entecavir. Ciclosporin may raise blood levels of Entecavir.

Moderate

Ciclosporin (Injection Route)

Ciclosporin may raise blood levels of Entecavir. Ciclosporin may raise blood levels of Entecavir.

Moderate

Tacrolimus (Oral Route)

Tacrolimus may raise blood levels of Entecavir. Tacrolimus may raise blood levels of Entecavir.

Frequently asked questions

How should Samhep-E 0.5mg Tablet be taken?

You should take Samhep-E 0.5mg Tablet exactly as prescribed by your doctor and continue taking it till your doctor tells you to stop. It is usually taken once a day on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. It is advised to take it around the same time every day. If not sure, consult your doctor.

Can Samhep-E 0.5mg Tablet cause liver problems?

Yes, Samhep-E 0.5mg Tablet can cause serious liver problems like hepatomegaly (enlargement of the liver) and steatosis (an increased build-up of fat in the liver). It is important to know that hepatomegaly along with steatosis is a serious medical emergency which requires immediate medical attention.

What are the symptoms of serious liver problems?

The symptoms of liver problems include jaundice (a condition in which your skin or the white part of your eyes turns yellow), dark-colored urine, light-colored stools, loss of appetite, nausea and stomach pain. These symptoms are more common in women, overweight patients, or if you have been on Samhep-E 0.5mg Tablet for a long time. Immediately contact your doctor if you experience any such symptoms.

What is drug resistance? Can I develop drug resistance with Samhep-E 0.5mg Tablet?

Drug resistance is a state where the medicine which was once effective in treating an infection becomes ineffective. This mainly happens due to the ability acquired by the virus or bacteria to get modified inside the body which affects the overall working of the medicine. Hence, the medicine is no longer able to fight against the virus or bacteria. Generally, drug resistance with Samhep-E 0.5mg Tablet is more likely to happen if you take less dose than what is recommended.

How long should I take Samhep-E 0.5mg Tablet?

Do not stop taking entecavir without consulting your doctor. Stopping entecavir before treatment may worsen your hepatitis. This can happen during the first several months after you stop taking entecavir. Take the medicine strictly as advised and do not miss any dose.

What if HIV infection co-exists with HBV infection? Will this affect treatment with Samhep-E 0.5mg Tablet?

The use of Samhep-E 0.5mg Tablet is not recommended in HBV patients who are also diagnosed with HIV, until and unless these patients start taking medicines for HIV management. Starting Samhep-E 0.5mg Tablet in such patients may cause resistance to the prescribed HIV medicines. Therefore, doctors recommend tests for HIV in patients diagnosed with HBV infection before starting treatment with Samhep-E 0.5mg Tablet.

Can Samhep-E 0.5mg Tablet cure hepatitis B?

No, Samhep-E 0.5mg Tablet does not cure hepatitis B but may improve the condition of the liver. The medicine may help decrease the amount of hepatitis B virus (HBV) present in the body. This is done by limiting the ability of HBV to multiply and further infect new liver cells.

Fact Box

Chemical Class

Nucleoside and nucleotide analoguesues

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)

Related lab tests

Hepatitis B (Core) IgM Antibody

Hepatitis B s (Surface) Antigen

Hepatitis C Virus Total Antibody

References

Acosta EP, Flexner C. Antiviral Agents (Nonretroviral). In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1616-617.
Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 869.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 474-75.
Entecavir. Uxbridge, Middlesex: Bristol-Myers Squibb Pharmaceuticals limited; 2006 [revised 1 Feb. 2019] (online) Available from:
Entecavir. Princeton, New Jersey: Bristol-Myers Squibb; 2005 [revised Oct. 2012]. [Accessed 31 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 31 Mar. 2019] (online) Available from:
Entecavir [Prescribing Information]. Waterford, Ireland: EirGen Pharma Ltd.; 2017. [Accessed 22 Jun. 2023] (online) Available from:
Entecavir [Prescribing Information]. Princeton, NJ: Bristol-Myers Squibb Company; 2024. [Accessed 19 Jan. 2026] (online). Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Samarth Life Sciences Pvt Ltd
Address: Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Samhep-E 0.5mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Samhep-E 0.5mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Samhep-E Tablet

Benefits of Samhep-E Tablet

Side effects of Samhep-E Tablet

How to use Samhep-E Tablet

How Samhep-E Tablet works

All substitutes for Samhep-E 0.5mg Tablet

Entavir 0.5mg Tablet

X Vir 0.5mg Tablet

Hepalo 0.5 Tablet

Encure Tablet

Entehep 0.5 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ciclosporin (Oral Route)

Ciclosporin (Injection Route)

Tacrolimus (Oral Route)

Frequently asked questions

How should Samhep-E 0.5mg Tablet be taken?

Can Samhep-E 0.5mg Tablet cause liver problems?

What are the symptoms of serious liver problems?

What is drug resistance? Can I develop drug resistance with Samhep-E 0.5mg Tablet?

How long should I take Samhep-E 0.5mg Tablet?

What if HIV infection co-exists with HBV infection? Will this affect treatment with Samhep-E 0.5mg Tablet?

Can Samhep-E 0.5mg Tablet cure hepatitis B?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Hepatitis B (Core) IgM Antibody

Hepatitis B s (Surface) Antigen

Hepatitis C Virus Total Antibody

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests