Relugoliz Tablet

Relugolix (40mg)+ Estradiol (1mg)+ Norethindrone (0.5mg)

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Relugoliz Tablet is a medicine used during heavy menstrual bleeding caused by uterine fibroids and pain related to endometriosis in premenopausal women. It helps reduce excessive bleeding during periods and relieves pelvic pain, improving comfort so that a woman can perform daily activities.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 28 Aug 2026 | 01:04 AM (IST)

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Relugoliz Tablet

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Same composition

Reluease Tablet

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Relugolix (40mg) + Estradiol (1mg) + Norethindrone (0.5mg)

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General Information

Contains

Relugolix (40mg)+ Estradiol (1mg)+ Norethindrone (0.5mg)

Marketer

MSN Laboratories Private Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

Relugoliz Tablet should be taken as advised by a doctor. The dose and duration depend on the condition and response to the therapy. It is important to continue the medicine for as long as your doctor recommends. The most common side effects may include hot flushes, dizziness, abnormal vaginal bleeding, and mood changes. These side effects are usually mild and do not require medical attention. There is a risk of blood clots and bone thinning, so regular check-ups with your doctor are usually recommended.

Before taking this medicine, inform your doctor if you have liver problems, any hormonal disorders, or any other medical conditions. Also, tell your doctor about all other medicines you are taking. Regular medical follow-up may be needed to monitor symptoms and overall health during treatment.

Uses of Relugoliz Tablet

Benefits of Relugoliz Tablet

Treatment of Endometriosis
Endometriosis is a medical condition that can cause ongoing pelvic pain in some women. Relugoliz Tablet helps in relieving pain, making the condition more manageable by reducing discomfort and improving daily functioning.

Treatment of Uterine fibroids
Uterine fibroids are medical conditions that can cause heavy bleeding in some women. Relugoliz Tablet helps in reducing heavy menstrual bleeding. This can make the condition more manageable by helping women carry out daily activities more comfortably.

Side effects of Relugoliz Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Relugoliz

Back pain
Low sexual desire
Thinning of hair
Headache
Increased sweating
Joint pain
Night sweats

How to use Relugoliz Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Relugoliz Tablet may be taken with or without food.

How Relugoliz Tablet works

Relugoliz Tablet helps reduce heavy menstrual bleeding and pain by gently maintaining hormonal balance in the female body. Relugolix acts as a gonadotropin-releasing hormone (GnRH) receptor antagonist, helping lower the production of hormones that trigger excessive bleeding and pain by suppressing ovarian estrogen production. This helps reduce the overgrowth of the uterine lining. Estradiol is added to help mitigate problems linked to very low estrogen levels, such as bone loss and hot flashes. Norethindrone acetate helps protect the uterine lining (endometrium) and keep it stable, helping prevent excessive thickening and further reducing bleeding. Together, Relugoliz Tablet leads to lighter periods and less pain. Some women may notice temporary effects such as slight changes in their menstrual cycle, breast tenderness, or mood changes, especially at the beginning of treatment.

All substitutes for Relugoliz Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Seek immediate medical help if you notice symptoms of a blood clot, such as sudden chest pain or tightness, shortness of breath, difficulty breathing, or coughing up blood.
Some women may experience mood changes such as low mood, irritability, or anxiety due to hormonal effects, and these symptoms should be discussed promptly with a healthcare provider.
Relugoliz Tablet should not be used in women with osteoporosis or severe bone loss, as further reduction in estrogen levels may worsen bone strength and increase fracture risk.
Avoid using Relugoliz Tablet if you have unexplained or undiagnosed abnormal uterine or vaginal bleeding.
Relugoliz Tablet should not be used in women with known/suspected breast cancer or other hormone-dependent cancers, since hormonal components may stimulate tumor growth.
Dark chocolate and fruits like bananas and berries may help relieve the pain due to period cramps.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Relugoliz Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Relugoliz Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Relugoliz Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Relugoliz Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

SAFE IF PRESCRIBED

Relugoliz Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

UNSAFE

Relugoliz Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

Can any woman use Relugoliz Tablet?

No. Relugoliz Tablet cannot be used by any woman, as it is indicated for menstruating women. Your doctor will decide if this medicine is appropriate for you.

Can Relugoliz Tablet be used in patients with liver disease?

No. Relugoliz Tablet should not be used in patients with known liver disease, as it may worsen liver function and make the prevailing condition worse.

Is Relugoliz Tablet safe for patients with a history of blood clots?

No. Relugoliz Tablet should be avoided in patients with current or past blood clots. The hormones in this medicine (estrogen and progestin) can make the blood clot more easily, which increases the chance of developing another blood clot.

Can breastfeeding mothers take Relugoliz Tablet?

No. Breastfeeding mothers should not take Relugoliz Tablet because the medicine can pass into breast milk and may affect the baby. It is best to consult a doctor for a safer option while breastfeeding.

Can Relugoliz Tablet affect blood pressure?

Yes. Relugoliz Tablet may affect blood pressure. Regular monitoring is advised, especially in patients with hypertension. Consult your doctor in case of elevated blood pressure.

Can long-term use of Relugoliz Tablet increase safety risks?

Yes. Prolonged use may increase safety risks, including weakening of the bones. It should not be used by people who already have osteoporosis, as it may make bone problems worse. Use this medicine only for as long as your doctor recommends.

Should I inform my doctor about other medical conditions before using Relugoliz Tablet?

Yes. Inform your doctor about all current or past medical conditions, as some may make Relugoliz Tablet unsafe for you.

Fact Box

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: A)Macmillon Pharmaceuticals Pvt. Ltd.
Address: A)62‑63, Vijay Nagar, Batala Road, Amritsar – 143001

Marketer details

Name: MSN Laboratories Private Limited
Address: Plot No. 7-2-B 47 & B-48 Industrial Estate, Sanathnagar, Fathenagar (V), Balanagar (M), Medchal - Malkajgiri (D), Telangana, India - 500018.

Vendor Details

Country of origin: India

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Relugoliz Tablet

Relugoliz Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Relugoliz Tablet

Benefits of Relugoliz Tablet

Side effects of Relugoliz Tablet

How to use Relugoliz Tablet

How Relugoliz Tablet works

All substitutes for Relugoliz Tablet

Reluease Tablet

Reluzesta Tablet

Regestrone LX 40mg + 1mg + 0.5mg Tablet

Estrogolix Tablet

Reluher Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

Can any woman use Relugoliz Tablet?

Can Relugoliz Tablet be used in patients with liver disease?

Is Relugoliz Tablet safe for patients with a history of blood clots?

Can breastfeeding mothers take Relugoliz Tablet?

Can Relugoliz Tablet affect blood pressure?

Can long-term use of Relugoliz Tablet increase safety risks?

Should I inform my doctor about other medical conditions before using Relugoliz Tablet?

Fact Box

Habit Forming

Therapeutic Class

References

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Have issue with the content

Disclaimer

Manufacturer details

Marketer details

Vendor Details

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