Prostaver 500mcg Injection

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 19 Jan 2026 | 10:44 AM (IST)

Prostaver 500mcg Injection is used to treat patent ductus arteriosus (PDA), a heart defect that occurs in newborns. It improves blood circulation in such babies and helps treat this defect.

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General Information

Contains

Alprostadil (500mcg)

Marketer

Pristyn

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Prostaver 500mcg Injection is given as an injection by a doctor or nurse and should not be used without medical supervision. The most common side effects of this medicine are interrupted breathing (apnea) and a high temperature for a short time period (transient pyrexia/fever). If your baby has these or any other side effects, let your doctor know.

All babies can have Prostaver 500mcg Injection if they need it. The doctor will carry out tests before deciding whether to give this medicine to your baby. However, if your baby develops any signs of allergy to this medicine, such as wheezing, breathlessness, swelling of the face, hands, itchy rash, or redness of the skin, it is advised to not use this medicine. Consult your doctor if you have any doubts.

Uses of Prostaver Injection

Treatment of Patent ductus arteriosus (PDA)

Benefits of Prostaver Injection

Treatment of Patent ductus arteriosus (PDA)
Patent ductus arteriosus (PDA) is a persistent opening between the two major blood vessels leading from the heart. Usually this opening closes shortly after birth, but it can remain open and lead to this heart defect in babies. Prostaver 500mcg Injection improves blood flow in such babies who have PDA. It is given as an injection by a doctor or nurse in a hospital setup. Follow your doctor’s instructions carefully to get the most benefit.

Side effects of Prostaver Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Prostaver

Apnea (absence of breathing)
Fever

How to use Prostaver Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Prostaver Injection works

Prostaver 500mcg Injection is similar to a natural substance in the body called prostaglandin E1. It works by improving blood flow in newborn babies born with heart defects.

Quick tips

Prostaver 500mcg Injection is usually given in a hospital setting, so ensure your baby is closely monitored for breathing, heart rate, and oxygen levels during treatment.
Let the medical team know if your baby has any signs of apnea (pauses in breathing), as this is a possible side effect and may need support.
Your doctor may adjust the dose based on your baby’s weight and response. Regular monitoring helps avoid complications like flushing or low blood pressure.
Keep your baby warm and stable during treatment, as Prostaver 500mcg Injection can cause temporary changes in body temperature.
Be sure to follow up with the doctor for imaging tests (like echocardiography) to track how the ductus arteriosus is responding to the medicine.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Prostaver 500mcg Injection. Please consult your doctor.

Pregnancy

UNSAFE

Prostaver 500mcg Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Prostaver 500mcg Injection during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Prostaver 500mcg Injection does not usually affect your ability to drive.

Kidney

CAUTION

Prostaver 500mcg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Prostaver 500mcg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Prostaver with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Alfuzosin (Oral Route)

If concurrent use is essential, watch out for symptoms such as dizziness, fainting, blurred vision, nausea, fatigue, confusion, cold or clammy skin, shallow breathing or rapid pulse and consult your doctor if you experience them. They may adjust the doses as per the observations.

Moderate

Amlodipine (Oral Route)

Moderate

Atenolol (Oral Route)

Moderate

Atenolol (Injection Route)

Moderate

Bevacizumab (Injection Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Frequently asked questions

What is Prostaver 500mcg Injection used for?

Prostaver 500mcg Injection is a medication used in newborns with certain types of congenital heart defects. It helps keep a blood vessel called the ductus arteriosus open, which is essential for maintaining blood flow until corrective surgery can be performed. This is critical for babies born with heart conditions that affect blood flow to the lungs or body.

What should I expect during Prostaver 500mcg Injection treatment?

During treatment, your baby may be closely monitored in the NICU, have regular vital sign checks, undergo frequent blood tests, have continuous heart monitoring, and be watched for any side effects.

How long will my baby need Prostaver 500mcg Injection?

The duration depends on your baby's specific heart condition, timing of planned surgery, response to treatment, and overall health status. Your doctor will discuss the expected treatment timeline based on your baby's situation.

Who should not receive Prostaver 500mcg Injection?

Prostaver 500mcg Injection should not be used in newborns with persistent fetal circulation and abnormal lung-to-heart blood flow, which may cause lung swelling.

What are the serious side effects of Prostaver 500mcg Injection in infants?

Some serious side effects of Prostaver 500mcg Injection in infants include apnea (stopped breathing), seizures, heart rhythm problems, low blood pressure, bleeding disorders, and lung or kidney problems.

Why is breathing monitoring needed during Prostaver 500mcg Injection treatment?

Prostaver 500mcg Injection can cause apnea (breathing to stop temporarily), especially in babies under 2 kg. Babies on this medication must be in an ICU for close monitoring and possible ventilation.

What signs should doctors watch for during Prostaver 500mcg Injection treatment?

The doctors may monitor changes in breathing pattern, color changes in skin, changes in heart rate or rhythm, signs of infection, temperature changes, changes in blood pressure, etc.

Can Prostaver 500mcg Injection affect a baby’s bones or stomach?

Yes, long-term Prostaver 500mcg Injection use may cause bone thickening, especially in the legs (reversible after stopping), and stomach issues like gastric outlet blockage.

How long is Prostaver 500mcg Injection usually used?

Prostaver 500mcg Injection is used temporarily, ideally within the first 96 hours after birth, when it works best. The goal is to keep the blood vessel open only until surgery is possible.

Fact Box

Chemical Class

Prostaglandin analogues

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Prostaglandin E1 (PGE1) Analogues- ED

References

Smyth EM, Grosser T, FitzGerald GA. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 952.
Smyth EM, FitzGerald GA. The Eicosanoids: Prostaglandins, Tromboxanes, Leukotriens, & Related Compounds. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 325-26.
Alprostadil [EMC SmPC]. Sandwich, Kent: Pfizer Limited; 2019. [Accessed 03 Mar. 2021] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Pristyn
Address: 3108, Cobble Hills – 3, Prestige Shantiniketan, ITPL Main Road, White Field Bangalore

Vendor Details

Country of origin: India

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Prostaver 500mcg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Prostaver Injection

Benefits of Prostaver Injection

Side effects of Prostaver Injection

How to use Prostaver Injection

How Prostaver Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Alfuzosin (Oral Route)

Amlodipine (Oral Route)

Atenolol (Oral Route)

Atenolol (Injection Route)

Bevacizumab (Injection Route)

Frequently asked questions

What is Prostaver 500mcg Injection used for?

What should I expect during Prostaver 500mcg Injection treatment?

How long will my baby need Prostaver 500mcg Injection?

Who should not receive Prostaver 500mcg Injection?

What are the serious side effects of Prostaver 500mcg Injection in infants?

Why is breathing monitoring needed during Prostaver 500mcg Injection treatment?

What signs should doctors watch for during Prostaver 500mcg Injection treatment?

Can Prostaver 500mcg Injection affect a baby’s bones or stomach?

How long is Prostaver 500mcg Injection usually used?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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