proLET 25 Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

proLET 25 Tablet belongs to a class of medicines called barbiturates. It is used to treat and prevent epilepsy (seizures). They also have hypnotic properties. This means, they slow down the activity of the brain and can make you feel sleepy or dizzy.

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General Information

Contains

Primidone (25mg)

Marketer

Alteus Biogenics Pvt Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

proLET 25 Tablet may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it may be habit-forming with long-term use. If you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better.

Some common side effects of this medicine include nausea, vomiting, vertigo, low energy, impaired coordination, visual disturbance, and headache. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

Remember to consult your doctor if you notice severe rashes, especially accompanied by fever after taking this medicine. It should be noted that long-term use of this medicine can cause pain in joints also.

Uses of proLET Tablet

Benefits of proLET Tablet

Epilepsy/Seizures
proLET 25 Tablet slows down electrical signals in the brain that cause seizures (fits). It can also help reduce symptoms of seizures, such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. This medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Therefore, do not stop using this medicine even if you feel well, until your doctor advises you to. Missing doses may trigger a seizure.

Side effects of proLET Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of proLET

Drowsiness
Nausea
Vomiting
Vertigo
Low energy
Impaired coordination
Visual impairment
Nystagmus (involuntary eye movement)
Headache
Dizziness

How to use proLET Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. proLET 25 Tablet may be taken with or without food.

How proLET Tablet works

proLET 25 Tablet is a barbiturate. It controls seizures or fits by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Quick tips

Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
Some healthy tips to prevent seizures:
- Take a healthy diet along with regular exercise.
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/ laptop.
- Take your medication on time.
It makes you feel dizzy and drowsy. Avoid driving and activity requiring mental focus until you know how this medicine affects you.
Your doctor may get regular tests done to monitor the level of blood cells in your blood while taking this medication.
Inform your doctor if you notice mood changes and suicidal thoughts while taking proLET 25 Tablet.
Do not stop taking the medication suddenly, as it can reverse the seizures.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. proLET 25 Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

proLET 25 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

proLET 25 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Baby should be monitored for excessive sleepiness and weight gain.

Driving

UNSAFE

proLET 25 Tablet may cause side effects that could affect your ability to drive.

Kidney

CAUTION

proLET 25 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

proLET 25 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking proLET with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Aprepitant (Oral Route)

Do not consume Aprepitant with Primidone. Primidone may reduce blood levels of Aprepitant.

Severe

Ticagrelor (Oral Route)

Do not consume Ticagrelor with Primidone. Primidone may reduce blood levels of Ticagrelor.

Severe

Aripiprazole (Oral Route)

If concurrent use is essential, please consult your doctor. They may monitor your treatment and adjust the doses as per the observations. Primidone may reduce blood levels of Aripiprazole.

Severe

Lorlatinib (Oral Route)

Do not consume Lorlatinib with Primidone. Primidone may reduce blood levels of Lorlatinib.

Severe

Bortezomib (Injection Route)

Avoid concurrent use. Please consult with your doctor. Primidone may reduce efficacy of Bortezomib.

Frequently asked questions

Is proLET 25 Tablet habit forming?

Yes, if you use proLET 25 Tablet for a long time, you may become dependent on it. Moreover, stopping the medicine suddenly may also lead to withdrawal symptoms. Therefore, you must inform your doctor before stopping the proLET 25 Tablet.

Can I stop taking proLET 25 Tablet?

Do not stop taking proLET 25 Tablet even if you are feeling well, unless your doctor advises so. Suddenly stopping proLET 25 Tablet may cause unwanted effects commonly known as withdrawal symptoms. To prevent this, the dose of proLET 25 Tablet needs to be reduced gradually before completely stopping it.

What should I tell my doctor before taking this medicine?

Inform your doctor if you are taking any other medicines including medicines for epilepsy or seizures, medicines used to thin your blood (e.g., warfarin), birth control pills, medicines to control bacterial infection (e.g., chloramphenicol, metronidazole, and doxycycline), medicines to control viral infection (e.g., nelfinavir), and asthma medicines (e.g., theophylline and montelukast), etc. Also, inform your doctor if you are planning to become pregnant or are breastfeeding. Further, you should tell the doctor if you have ever had liver problems, kidney problems, lung problems, or porphyria (a rare blood pigment disorder).

What should I avoid while taking proLET 25 Tablet?

If proLET 25 Tablet makes you feel sleepy, avoid driving or operating heavy machinery. Alcohol consumption should be avoided since taking both together may cause excessive sleepiness. You should avoid getting pregnant since proLET 25 Tablet is associated with an increased risk of abnormalities in babies.

What are the serious side effects of using proLET 25 Tablet? How can I check for these side effects?

Severe allergic reactions, skin reactions, abnormalities in blood cells, and worsening of seizures are some of the serious side effects of proLET 25 Tablet. Severe allergic reactions may result in difficulty in breathing, swelling of the lips, tongue, face, or hives. Skin reactions may cause redness, pain, ulcers, blisters, shedding the outer layer of skin. If you have an abnormality of the blood cells, your skin may appear pale. Additionally you may suffer from abnormal bleeding or frequent bruising, fever, or sore throat.

Can proLET 25 Tablet cause headache?

Though headache is not a very common side effect of proLET 25 Tablet, it can occur in a few patients.

Does proLET 25 Tablet affect blood pressure?

No, proLET 25 Tablet does not have any effect on blood pressure.

Can I take proLET 25 Tablet and propranolol together?

While taking propranolol and proLET 25 Tablet together, your blood pressure should be monitored as proLET 25 Tablet may interfere with working of propranolol. Your doctor may modify your dose if needed.

How should I store this medicine?

Keep it in a cool dry place where the temperature stays below 25°C. Do not leave it on a windowsill or in the car on hot days. Keep it out of reach of children.

Fact Box

Chemical Class

Hydropyrimidines

Habit Forming

Yes

Therapeutic Class

NEURO CNS

Action Class

Barbiturates

References

Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 407-408.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1150-51.
Primidone. Paris, France: SERB; 2010 [revised 5 Aug. 2014]. [Accessed 17 Jun. 2019] (online) Available from:
Primidone. Warriewood, New South Wales: Link Medical Products Pty Ltd.; 2014. [Accessed 17 Jun. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 22 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Primidone. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alteus Biogenics Pvt Ltd
Address: 14-B Dover Lane, Kolkata - 700029, WB, India.

Vendor Details

Country of origin: India

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Why we need a prescription?

proLET 25 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of proLET Tablet

Benefits of proLET Tablet

Side effects of proLET Tablet

How to use proLET Tablet

How proLET Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Aprepitant (Oral Route)

Ticagrelor (Oral Route)

Aripiprazole (Oral Route)

Lorlatinib (Oral Route)

Bortezomib (Injection Route)

Frequently asked questions

Is proLET 25 Tablet habit forming?

Can I stop taking proLET 25 Tablet?

What should I tell my doctor before taking this medicine?

What should I avoid while taking proLET 25 Tablet?

What are the serious side effects of using proLET 25 Tablet? How can I check for these side effects?

Can proLET 25 Tablet cause headache?

Does proLET 25 Tablet affect blood pressure?

Can I take proLET 25 Tablet and propranolol together?

How should I store this medicine?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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