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Piosafe MF 15/500 Tablet

Pioglitazone (15mg)+ Metformin (500mg)

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Piosafe MF 15/500 Tablet is a combination medicine that helps control blood sugar levels. This medicine is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It helps in proper utilisation of insulin, thereby lowering the blood sugar level.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 12 Aug 2026 | 01:01 AM (IST)

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General Information

Contains

Pioglitazone (15mg)+ Metformin (500mg)

Marketer

Aristo Pharmaceuticals Pvt Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Piosafe MF 15/500 Tablet should be taken in the dose and duration as advised by your doctor. It must be taken with food to avoid stomach upset. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Overdose may lead to low blood sugar (hypoglycemia).

Some people may develop common side effects like nausea, loss of appetite, taste changes, stomach pain, diarrhea, and edema (swelling). However, these are usually not bothersome. If these do not resolve or worry you, please consult your doctor.

Before taking this medicine, inform your doctor if you have any kidney, liver or heart problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Your doctor will check your kidney function tests before starting treatment with it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects.

Uses of Piosafe MF Tablet

Treatment of Type 2 diabetes mellitus

Benefits of Piosafe MF Tablet

Treatment of Type 2 diabetes mellitus
Piosafe MF 15/500 Tablet is a medicine that helps to control high blood glucose (sugar) levels. It helps get rid of extra glucose from your body through urine. It also improves the body’s response to the hormone insulin, which is responsible for regulating blood glucose (sugar) levels in our body. The insulin helps to lower your blood glucose levels and prevents them from rising after taking meals. You should keep taking it for as long as it is prescribed.
Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level you will reduce the risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.

Side effects of Piosafe MF Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Piosafe MF

Diarrhea
Edema (swelling)
Headache
Upper respiratory tract infection
Weight gain

How to use Piosafe MF Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Piosafe MF 15/500 Tablet should be taken with or after food.

How Piosafe MF Tablet works

Piosafe MF 15/500 Tablet is a combination of two antidiabetic medicines:

All substitutes for Piosafe MF 15/500 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take it as per the dose and duration prescribed by your doctor.
Monitor your blood sugar level regularly while you are taking this medicine.
It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Inform your doctor if you notice weight gain, shortness of breath, irregular heartbeat, or any abnormal swelling.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Piosafe MF 15/500 Tablet

Pregnancy

CONSULT YOUR DOCTOR

The safety of Piosafe MF 15/500 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Piosafe MF 15/500 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Piosafe MF 15/500 Tablet may cause temporary visual disturbances. Do not drive until your vision is clear.

Kidney

UNSAFE

Piosafe MF 15/500 Tablet is unsafe to use in patients with kidney disease and should be avoided.

Liver

UNSAFE

Piosafe MF 15/500 Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

What is Piosafe MF 15/500 Tablet used for?

Piosafe MF 15/500 Tablet is used to help control blood sugar levels in adults with type 2 diabetes. It works best when combined with a proper diet and regular exercise, especially in people who have not responded well to a single diabetes medication, such as metformin or pioglitazone alone.

Can Piosafe MF 15/500 Tablet cause low blood sugar?

While Piosafe MF 15/500 Tablet rarely causes low blood sugar (hypoglycemia) on its own, the risk increases if it is taken with insulin or other diabetes medicines. Symptoms of low blood sugar may include dizziness, sweating, or shakiness. Always carry a quick sugar source like glucose tablets or candy.

Who should not take Piosafe MF 15/500 Tablet?

Individuals should not take Piosafe MF 15/500 Tablet if they have heart failure, liver or kidney disease, bladder cancer, or a history of alcohol abuse. It is also not safe during pregnancy or breastfeeding.

What are the serious side effects of Piosafe MF 15/500 Tablet?

Serious side effects of Piosafe MF 15/500 Tablet may include lactic acidosis (a rare but life-threatening buildup of acid in the blood), fluid retention or swelling, fractures, or vision problems. Seek medical help immediately if you feel very weak, have muscle pain, trouble breathing, or an irregular heartbeat.

What precautions should elderly patients take with Piosafe MF 15/500 Tablet?

Older adults should use Piosafe MF 15/500 Tablet with caution, as they may be more sensitive to side effects like lactic acidosis, bone fractures, and fluid retention. Your doctor may adjust the dose carefully.

What should I do before surgery or any body scans?

Your doctor may advise you to stop taking Piosafe MF 15/500 Tablet before surgery or any test using contrast dye (like CT scans), as it can temporarily affect kidney function and increase the risk of lactic acidosis. Your doctor will tell you when it is safe to restart this medicine.

Fact Box

Habit Forming

Therapeutic Class

ANTI DIABETIC

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

User feedback

Patients taking Piosafe MF 15/500 Tablet

Twice A Day

100%

What are you using Piosafe MF Tablet for?

Others

33%

Type 2 diabetes mellitus

33%

Polycystic ovarian syndrome (PCOS)

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Aristo Pharmaceuticals Pvt Ltd
Address: Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India. / Regd, Office: 23 -A Shah Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai-400053 Maharashtra, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Piosafe MF 15/500 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Anti Diabetic

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Piosafe MF 15/500 Tablet

Piosafe MF 15/500 Tablet

Cash on delivery

Free Return

Expiry after

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Piosafe MF Tablet

Benefits of Piosafe MF Tablet

Side effects of Piosafe MF Tablet

How to use Piosafe MF Tablet

How Piosafe MF Tablet works

All substitutes for Piosafe MF 15/500 Tablet

Piokind-M 15 Tablet

Metrose P 15mg/500mg Tablet

Piogood-M Tablet

Piozone M 15mg/500mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Piosafe MF 15/500 Tablet used for?

Can Piosafe MF 15/500 Tablet cause low blood sugar?

Who should not take Piosafe MF 15/500 Tablet?

What are the serious side effects of Piosafe MF 15/500 Tablet?

What precautions should elderly patients take with Piosafe MF 15/500 Tablet?

What should I do before surgery or any body scans?

Fact Box

Habit Forming

Therapeutic Class

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

User feedback

Patients taking Piosafe MF 15/500 Tablet

What are you using Piosafe MF Tablet for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests