Onetrela 50 Tablet
Prescription RequiredProduct introduction
Onetrela 50 Tablet is an oral weekly drug for the control of type 2 diabetes. It acts by inhibiting the enzyme DPP-4, which favors enhanced release of insulin and suppressed production of sugar in the liver, thus enhancing the control of blood sugar after meals.
In order for Onetrela 50 Tablet to help regulate blood sugar levels, take it precisely as directed, usually once a week. Skipping doses will limit its glucose-control ability. To remain consistent, select a regular day of the week for your dose, and consider putting reminders in place. Take it with food, and have follow-ups regularly with your doctor to check on your response and modify treatment where necessary.
Common side effects of Onetrela 50 Tablet include hypoglycemia, blisters, and bowel obstruction. If side effects persist or worsen, consult your doctor. Always use as directed to minimize risks and ensure safe use.
Onetrela 50 Tablet is contraindicated in patients with a known hypersensitivity to the drug or any of its components. It should be used cautiously in people with a history of pancreatitis, kidney impairment, or heart problems. Although rare, serious allergic reactions and joint pain have been reported. It is not recommended for use in type 1 diabetes or diabetic ketoacidosis. Patients should inform their doctor about all existing conditions and current medications to avoid adverse interactions.
Uses of Onetrela Tablet
Benefits of Onetrela Tablet
In Treatment of Type 2 diabetes mellitus
Type 2 diabetes is a chronic condition in which the body either fails to make enough insulin or cannot use it properly, resulting in high blood sugar levels. If left uncontrolled, diabetes can lead to severe complications such as heart disease, kidney impairment, and nerve damage.
Onetrela 50 Tablet controls blood glucose levels by enhancing the activity of incretin hormones, which enhance insulin secretion postprandially and lower the liver's glucose output. Its distinct benefit is its once-weekly dosing, which provides convenience and could also ensure patient compliance. Through more level maintenance of blood sugar, it aids in better long-term glucose control and lowers the risk of diabetic complications.
Onetrela 50 Tablet controls blood glucose levels by enhancing the activity of incretin hormones, which enhance insulin secretion postprandially and lower the liver's glucose output. Its distinct benefit is its once-weekly dosing, which provides convenience and could also ensure patient compliance. Through more level maintenance of blood sugar, it aids in better long-term glucose control and lowers the risk of diabetic complications.
Side effects of Onetrela Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Onetrela
- Hypoglycemia (low blood glucose level)
- Blisters
- Intestinal obstruction
How to use Onetrela Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Onetrela 50 Tablet should be taken with or after food.
How Onetrela Tablet works
Onetrela 50 Tablet is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It inhibits the DPP-4 enzyme, which would otherwise be responsible for degrading incretin hormones such as GLP-1 and GIP. These hormones regulate blood sugar by enhancing insulin secretion and suppressing glucagon after meals. By extending the effects of incretins, it enhances insulin secretion during meals and decreases liver-sugar production. This provides improved regulation of blood glucose, especially postprandially. Its long duration enables once-weekly administration, improving convenience and compliance.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Onetrela 50 Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
The safety of Onetrela 50 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Onetrela 50 Tablet during breastfeeding is not available. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether Onetrela 50 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney
CAUTION
Onetrela 50 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver
SAFE IF PRESCRIBED
Onetrela 50 Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.
What if you forget to take Onetrela Tablet?
If you miss a dose of Onetrela 50 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Monitor your blood sugar regularly, especially if combining with other antidiabetic drugs.
- Watch for signs of pancreatitis, severe stomach pain, nausea, or vomiting, and report them immediately.
- Inform your doctor if you have kidney or liver issues, as dose adjustments may be needed.
- Continue with healthy eating and physical activity, as Onetrela 50 Tablet works best when paired with lifestyle changes.
- If you feel unusually tired, dizzy, or develop a skin rash, seek medical help to rule out rare side effects.
- Make sure to attend regular check-ups to monitor HbA1c and other diabetes-related health markers.
Fact Box
Chemical Class
Benzonitriles
Habit Forming
No
Therapeutic Class
ANTI DIABETIC
Action Class
Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
Patient concerns
FAQs
What happens if I miss a dose of Onetrela 50 Tablet?
If you miss a dose, take it as soon as you remember unless it is close to the next scheduled dose. Never double up.
Does Onetrela 50 Tablet cause weight gain?
It is generally weight-neutral, which means it does not typically cause weight gain.
Is Onetrela 50 Tablet safe for older adults?
It can be used in older adults but may require dose adjustment, especially in those with kidney issues.
Can I drink alcohol while on Onetrela 50 Tablet?
It is best to limit alcohol intake as it can affect blood sugar levels and increase the risk of side effects.
Can I stop taking Onetrela 50 Tablet if my sugar levels are normal?
No, always consult your doctor before stopping or changing your medication.
Does Onetrela 50 Tablet cure diabetes?
No, it helps manage blood sugar levels but does not cure diabetes.
Want to share the information?
Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Trelagliptin [Product Monograph]. Karachi, Pakistan: Getz Pharma Ltd., [Accessed 30/07/2025] (online) Available from:
- Trelagliptin [Product Monograph]. Mumbai, Maharashtra: Zuventus Healthcare Ltd.; 2025. [Accessed 30/07/2025] (online) Available from:
Marketer details
Name: Alkem Laboratories Ltd
Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Country of origin: India
Expires on or after: June, 2027
A licensed vendor partner from your nearest location will deliver Onetrela 50 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: June, 2027
A licensed vendor partner from your nearest location will deliver Onetrela 50 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Lab tests offered by us
Related/Popular tests
MRP₹280 10% OFF
₹253
Inclusive of all taxes
4.0 tablets in 1 strip
The price displayed is the MRP (inclusive of applicable taxes). Any additional fee (such as shipping fee, handling and/or platform fee etc.) will be clearly disclosed before you complete your purchase.
Get by Thursday, 26 February
Delivering to: