Trelagliptin

Last updated 31 Jul 2025 | 05:43 PM (UTC)

Trelagliptin Uses

Trelagliptin is used in the treatment of type 2 diabetes mellitus.

How Trelagliptin works

Trelagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It inhibits the DPP-4 enzyme, which would otherwise be responsible for degrading incretin hormones such as GLP-1 and GIP. These hormones regulate blood sugar by enhancing insulin secretion and suppressing glucagon after meals. By extending the effects of incretins, it enhances insulin secretion during meals and decreases liver-sugar production. This provides improved regulation of blood glucose, especially postprandially. Its long duration enables once-weekly administration, improving convenience and compliance.

Common side effects of Trelagliptin

Hypoglycemia (low blood glucose level), Blisters, Intestinal obstruction

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Medicine brands for Trelagliptin

Alkem Laboratories Ltd

₹280 to ₹420

2 variant(s)

Trelaglip

Zuventus Healthcare Ltd

₹245 to ₹567

4 variant(s)

Expert advice for Trelagliptin

Monitor your blood sugar regularly, especially if combining with other antidiabetic drugs.
Watch for signs of pancreatitis, severe stomach pain, nausea, or vomiting, and report them immediately.
Inform your doctor if you have kidney or liver issues, as dose adjustments may be needed.
Continue with healthy eating and physical activity, as Trelagliptin works best when paired with lifestyle changes.
If you feel unusually tired, dizzy, or develop a skin rash, seek medical help to rule out rare side effects.
Make sure to attend regular check-ups to monitor HbA1c and other diabetes-related health markers.

Frequently asked questions for Trelagliptin

Q. What happens if I miss a dose of Trelagliptin?

If you miss a dose, take it as soon as you remember unless it is close to the next scheduled dose. Never double up.

Q. Does Trelagliptin cause weight gain?

It is generally weight-neutral, which means it does not typically cause weight gain.

Q. Is Trelagliptin safe for older adults?

It can be used in older adults but may require dose adjustment, especially in those with kidney issues.

Q. Can I drink alcohol while on Trelagliptin?

It is best to limit alcohol intake as it can affect blood sugar levels and increase the risk of side effects.

Q. Can I stop taking Trelagliptin if my sugar levels are normal?

No, always consult your doctor before stopping or changing your medication.

Q. Does Trelagliptin cure diabetes?

No, it helps manage blood sugar levels but does not cure diabetes.