Obnyx 80 Tablet

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 19 Mar 2026 | 02:22 PM (IST)

Obnyx 80 Tablet is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

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General Information

Contains

Enzalutamide (80mg)

Marketer

Zydus Lifesciences Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Obnyx 80 Tablet should be taken with or without food, preferably at a fixed time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Headache, hot flashes, weakness and high blood pressure is very common side effect of this medicine. Other than this, fractures, falls, dry skin, pruritus,decreased appetite, and constipation might be observed as side effects. Regular blood tests are required to check your blood cells along with liver function during treatment with this medicine. It makes your skin more sensitive towards sunlight, hence take extra caution while going out.

Before taking it, tell your doctor if have diabetes, seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.

Uses of Obnyx Tablet

Treatment of Prostate cancer

Benefits of Obnyx Tablet

Treatment of Prostate cancer
Prostate cancer is a condition where abnormal cells grow in the prostate gland, which can spread to other parts of the body if untreated. Obnyx 80 Tablet helps block the action of male hormones that promote cancer growth, slowing disease progression and improving survival outcomes.

Side effects of Obnyx Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Obnyx

Headache
Hot flashes
Weakness
High blood pressure
Fatigue
Decreased appetite
Constipation
Dry skin
Itching
Fall
Fracture

How to use Obnyx Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Obnyx 80 Tablet may be taken with or without food.

How Obnyx Tablet works

Obnyx 80 Tablet is an antiandrogen. It works by blocking the effect of the natural male hormones on the growth of prostate cells.

Quick tips

You have been prescribed Obnyx 80 Tablet for the treatment of prostate cancer.
Take it with or without food, preferably at the same time every day.
Do not drive or do anything requiring concentration unless you know how Obnyx 80 Tablet affects you.
It may cause your skin to become light sensitive. Avoid direct exposure to excessive sunlight and use sunscreen when outdoors.
If you are diabetic, monitor your blood glucose regularly while taking Obnyx 80 Tablet.
Your doctor may want you to have regular blood tests to monitor your liver function while you are taking this medicine. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Do not stop taking the medication without talking to your doctor first.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Obnyx 80 Tablet.

Pregnancy

UNSAFE

Obnyx 80 Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Obnyx 80 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Obnyx 80 Tablet may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Obnyx 80 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

SAFE IF PRESCRIBED

Obnyx 80 Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.

Interaction with drugs

Taking Obnyx with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Nevirapine (Oral Route)

Do not consume Nevirapine with Enzalutamide. Enzalutamide may reduce blood levels of Nevirapine.

Severe

Bortezomib (Injection Route)

Avoid concurrent use. Please consult with your doctor. Enzalutamide may reduce efficacy of Bortezomib.

Severe

Irinotecan (Injection Route)

Do not consume Irinotecan with Enzalutamide. Enzalutamide may fasten the elimination of Irinotecan and its active form.

Severe

Sirolimus (Injection Route)

Do not consume Sirolimus with Enzalutamide. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Enzalutamide may reduce blood levels of Sirolimus.

Severe

Aprepitant (Oral Route)

Do not consume Aprepitant with Enzalutamide. Enzalutamide may reduce blood levels of Aprepitant.

Frequently asked questions

What is Obnyx 80 Tablet used for?

Obnyx 80 Tablet is used to treat prostate cancer that has spread, or is resistant to hormone therapy. It works by blocking the effect of male hormones (androgens) that help cancer cells grow.

Who should not take Obnyx 80 Tablet?

People should not take Obnyx 80 Tablet if they are allergic to it or any of its ingredients. It is also not recommended for women, especially during pregnancy, due to the risk of harm to an unborn baby.

Can Obnyx 80 Tablet cause seizures?

Yes, Obnyx 80 Tablet can increase the risk of seizures. Patients with a history of seizures, brain injury, stroke, or those taking medicines that lower the seizure threshold need extra caution.

What are the serious side effects of Obnyx 80 Tablet?

Serious side effects of Obnyx 80 Tablet may include seizures, severe allergic reactions, sudden chest pain, shortness of breath, swelling in legs, falls, memory problems, or unusual bleeding. Seek medical attention right away if these occur.

Can Obnyx 80 Tablet affect memory or thinking?

Yes, Obnyx 80 Tablet may cause problems such as memory loss, confusion, trouble concentrating, or a higher risk of falls. These side effects may impact daily activities.

Does Obnyx 80 Tablet affect blood pressure or heart health?

Yes, Obnyx 80 Tablet can cause high blood pressure, and may increase the risk of heart problems such as heart attack, or heart failure. Regular monitoring is important, especially if you already have heart disease.

Does Obnyx 80 Tablet affect fertility in men?

Yes, Obnyx 80 Tablet may reduce fertility in men, and can harm an unborn child if the father is taking it during conception. Effective contraception is recommended during treatment, and for at least 3 months after stopping.

Fact Box

Chemical Class

Phenylimidazolidines

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Androgen Receptor Antagonists

Related lab tests

Prostate Specific Antigen (Free) PSA

Prostate Specific Antigen (Total) PSA

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 474-75.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Enzalutamide [Product Information]. Netherlands: Astellas Pharma Europe B.V.; [Accessed on 27 Mar. 2019] (online) Available from:
CiplaMed: Enzalutamide [Prescribing Information]. 2022. [Accessed 20 Feb. 2024] (online) Available from:
Enzalutamide [Product Monograph]. Markham, ON: Astellas Pharma Canada, Inc.; 2020. [Accessed 14 Mar. 2026] (online) Available from:
Enzalutamide [Prescribing Information]. Northbrook, IL: Astellas Pharma US, Inc.; 2018. [Accessed 14 Mar. 2026] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zydus Lifesciences Ltd
Address: Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481 / Scheme No. 63, Survey No. 536, Khoraj(Gandhinagar), Near Vaishnodevi Circle, Ahmedabad - 382481, Gujarat.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Obnyx 80 Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Obnyx Tablet

Benefits of Obnyx Tablet

Side effects of Obnyx Tablet

How to use Obnyx Tablet

How Obnyx Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Nevirapine (Oral Route)

Bortezomib (Injection Route)

Irinotecan (Injection Route)

Sirolimus (Injection Route)

Aprepitant (Oral Route)

Frequently asked questions

What is Obnyx 80 Tablet used for?

Who should not take Obnyx 80 Tablet?

Can Obnyx 80 Tablet cause seizures?

What are the serious side effects of Obnyx 80 Tablet?

Can Obnyx 80 Tablet affect memory or thinking?

Does Obnyx 80 Tablet affect blood pressure or heart health?

Does Obnyx 80 Tablet affect fertility in men?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Prostate Specific Antigen (Free) PSA

Prostate Specific Antigen (Total) PSA

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests