Nitrogesic Rectal Ointment

Nitroglycerin (0.2% w/w)

Genuine

Authenticity Assured

Prescription

required

Nitrogesic Rectal Ointment is a medicine used for relieving the pain associated with anal fissures (tear in the lining of the anus). It improves blood flow and reduces the pressure in anal tissues. This promotes healing of fissures and relieves pain.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 07 Jan 2026 | 03:33 PM (IST)

₹93.3 MRP ₹101.258% off

Gurgaon

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General Information

Storage

Store below 30°C

The content is shown in English

Product introduction

Nitrogesic Rectal Ointment is for external use only. Use it in the dose and duration as advised by your doctor. Clean and dry the affected area and gently apply it over the affected area. Do not get it into your mouth, eyes, or nose. In case of accidental contact, rinse it thoroughly with clean water.

On using this medicine, some people may experience headache. You may also experience slight anal irritation upon application of the medicine. This is temporary and usually resolves on its own in some time. You should consult your doctor if it does not resolve or persists for a longer duration.

Do not use the medicine if you are taking medicines to treat high blood pressure in your lungs (pulmonary hypertension), or if you have anemia or glaucoma (increased pressure inside the eye). Always tell your doctor what other health conditions you have and what other medicines you are taking. If you are pregnant, thinking about becoming pregnant, or breastfeeding, ask your doctor before taking this medicine.

Uses of Nitrogesic Rectal Ointment

Anal fissure

Benefits of Nitrogesic Rectal Ointment

Anal fissure
An anal fissure is a small tear in the lining of the anus that causes pain, bleeding, and discomfort during or after bowel movements. Nitrogesic Rectal Ointment helps by relaxing the muscles around the anus, reducing pain, and improving blood flow to the area, which supports faster healing. This provides relief from discomfort and aids in the recovery of the fissure.

Side effects of Nitrogesic Rectal Ointment

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nitrogesic

Application site reactions (burning, irritation, itching and redness)
Headache

How to use Nitrogesic Rectal Ointment

This medicine is for external use only. Use it in the dose and duration as advised by your doctor.

How Nitrogesic Rectal Ointment works

Nitrogesic Rectal Ointment works by relaxing the muscles around the blood vessels which reduces pressure inside the anus and relieves pain. This treats pain associated with anal fissures, hemorrhoids, and hemorrhoidectomy.

Quick tips

Nitrogesic Rectal Ointment may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
Do not consume alcohol while taking Nitrogesic Rectal Ointment as it may cause increased dizziness.
It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
You may develop tolerance to Nitrogesic Rectal Ointment with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Nitrogesic Rectal Ointment as it may cause low blood pressure.
You have been prescribed Nitrogesic Rectal Ointment for the prevention and treatment of heart-related chest pain (angina).
Eat healthy (low-fat, high-fiber, low-sodium diet), quit smoking, increase your physical activity, watch your weight and reduce stress.
Nitrogesic Rectal Ointment may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
Do not consume alcohol while taking Nitrogesic Rectal Ointment as it may cause increased dizziness.
It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
You may develop tolerance to Nitrogesic Rectal Ointment with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Nitrogesic Rectal Ointment as it may cause low blood pressure.

Safety advice

Alcohol

No interaction found/established

Pregnancy

CONSULT YOUR DOCTOR

The safety of Nitrogesic Rectal Ointment during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Nitrogesic Rectal Ointment during breastfeeding is not available. Please consult your doctor.

Driving

No interaction found/established

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Nitrogesic Rectal Ointment in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Nitrogesic Rectal Ointment in patients with liver disease.

Interaction with drugs

Taking Nitrogesic with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Sildenafil (Oral Route)

Do not consume Sildenafil with Nitroglycerin. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Nitroglycerin. Please consult your doctor.

Life-threatening

Tadalafil (Oral Route)

Do not consume Tadalafil with Nitroglycerin. If Tadalafil is essential, ensure a gap of at least 48 hours between taking Tadalafil and Nitroglycerin.

Life-threatening

Sildenafil (Oral Route)

Do not consume Sildenafil with Nitroglycerin. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Nitroglycerin. Please consult your doctor.

Life-threatening

Sildenafil (Injection Route)

Do not consume Sildenafil with Nitroglycerin. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Nitroglycerin. Please consult your doctor.

Life-threatening

Sildenafil (Injection Route)

Do not consume Sildenafil with Nitroglycerin. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Nitroglycerin. Please consult your doctor.

Frequently asked questions

Does Nitrogesic Rectal Ointment cure anal fissures?

No, Nitrogesic Rectal Ointment does not cure fissures. It reduces inflammation of mucous membrane and skin. It also helps to reduce irritation, pain and itching associated with anal fissures, thus providing symptomatic relief.

Why is my fissure not healing?

Fissures usually heal within a few weeks. But if your fissures do not improve then this could be due to the poor oxygen supply to the area being treated which further slows down the healing process. As a result, these fissures fail to heal and continue to get worse. You should consult a doctor immediately if you have been facing issues for a duration longer than a few weeks.

What should I eat and avoid in fissure?

You must take a fiber-rich diet such as vegetables, fresh fruits and whole grains if you have fissures. Drink plenty of water and avoid taking alcohol. This will ensure that your stools are soft and easy to pass. You can also take laxatives or fiber supplements if you are facing issues with digestion. Your doctor will suggest ways to avoid constipation and thereby promote healing of fissures.

Can spicy food cause fissures?

No, spicy foods do not cause fissures. But, they can irritate the fissures and worsen your symptoms. Therefore, it is advised that you avoid taking spicy foods if you are facing issues with your fissures.

How do you use Nitrogesic Rectal Ointment cream?

Follow your doctor’s instructions before using Nitrogesic Rectal Ointment. Apply a small amount of the ointment to the affected rectal area as directed. If this is to be used inside the rectum, attach the rectal applicator onto the tube. Insert the applicator gently and to full extent into the rectum. Gently squeeze the tube to deliver the medication while withdrawing it.

How long does it take to heal fissures?

Fissures usually heal within a few weeks. But, if they persist for longer than 4 to 6 weeks, they are termed as chronic fissures. Please consult your doctor without any delay if you have been noticing fissures for longer than 4 weeks.

What precautions do I need to take while using Nitrogesic Rectal Ointment?

Be careful not to get Nitrogesic Rectal Ointment into your eyes or mouth. If you happen to get it in your eyes, rinse off with plenty of water immediately and contact your doctor. You must not use Nitrogesic Rectal Ointment if you are allergic to it or any of its ingredients. Tell your doctor if you notice any allergic reaction while using it for the first time. Inform your doctor if you are taking any medicines regularly to prevent any allergic reaction with other medicines. Do not cover the area being treated with Nitrogesic Rectal Ointment with a bandage, as this may increase absorption of this medicine and increase the side effects. Do not use more than what is recommended to relieve your symptoms faster. Using more than what is advised will only increase the side effects. Let your doctor know if you are planning to conceive. Pregnant and breastfeeding mothers should use Nitrogesic Rectal Ointment only if prescribed by the doctor.

Fact Box

Chemical Class

Alkyl nitrates

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Nitric Oxide (NO) Donors

References

Michel T, Hoffman BB. Treatment of Myocardial Ischemia and Hypertension. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 747-55.
Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 191, 195-97.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 986-88.
Glyceryl trinitrate. Galashiels, Scotland: Kyowa Kirin Ltd.; 2009 [revised May 2016]. [Accessed 26 Jun. 2020] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Nitroglycerin. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Glyceryl trinitrate ointment [New Zealand Consumer Medicine Information]. Auckland, New Zealand: Pharmacy Retailing (NZ) Ltd.; 2017. [Accessed 02 Aug. 2023] (online) Available from:

User feedback

Patients taking Nitrogesic Rectal Ointment

Once A Day

45%

Twice A Day

38%

Thrice A Day

14%

Four Times A Day

What are you using Nitrogesic Rectal Ointment for?

Others

56%

Anal fissure

35%

Angina (heart-related chest pain)

Coronary artery disease

How much was the improvement?

Excellent

39%

Average

38%

Poor

23%

What were the side-effects while using Nitrogesic Rectal Ointment?

Headache

36%

Lightheadedness

14%

No Side Effect

14%

Flushing (sense of warmth in the face, ears, neck and trunk)

Habituation

How do you take Nitrogesic Rectal Ointment?

With or without food

68%

With food

19%

Empty stomach

13%

Please rate Nitrogesic Rectal Ointment on price

Average

51%

Expensive

26%

Not Expensive

23%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Troikaa Pharmaceuticals Ltd.
Address: Troikaa Pharmaceuticals Ltd., Registered Office: , 'Commerce House - 1', Satya Marg, Bodakdev, Ahmedabad-380 054. Gujarat, India.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Nitrogesic Rectal Ointment

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Nitrogesic Rectal Ointment

Benefits of Nitrogesic Rectal Ointment

Side effects of Nitrogesic Rectal Ointment

How to use Nitrogesic Rectal Ointment

How Nitrogesic Rectal Ointment works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Sildenafil (Oral Route)

Tadalafil (Oral Route)

Sildenafil (Oral Route)

Sildenafil (Injection Route)

Sildenafil (Injection Route)

Frequently asked questions

Does Nitrogesic Rectal Ointment cure anal fissures?

Why is my fissure not healing?

What should I eat and avoid in fissure?

Can spicy food cause fissures?

How do you use Nitrogesic Rectal Ointment cream?

How long does it take to heal fissures?

What precautions do I need to take while using Nitrogesic Rectal Ointment?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Nitrogesic Rectal Ointment

What are you using Nitrogesic Rectal Ointment for?

How much was the improvement?

What were the side-effects while using Nitrogesic Rectal Ointment?

How do you take Nitrogesic Rectal Ointment?

Please rate Nitrogesic Rectal Ointment on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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