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Nitrofirst 30mg Tablet

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 09 Apr 2026 | 01:18 PM (IST)
Nitrofirst 30mg Tablet is used to prevent heart-related chest pain (angina). It works by relaxing and widening blood vessels so blood can flow more easily to the heart. This medicine will not treat an angina attack that has already begun.
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Nitrofirst 30mg Tablet image
Nitrofirst 30mg Tablet image

Product introduction

Nitrofirst 30mg Tablet may be taken with or without food. Your doctor will decide the dose and how often you should take it. The dose may change from time to time depending on how well the medicine works. Take this medicine exactly as prescribed and continue taking it even if you feel well. It helps prevent chest pain in the future. If you stop taking it, your risk of chest pain may increase, especially if you stop suddenly. Lifestyle changes such as a healthy diet, regular exercise, and avoiding smoking may help this medicine work better.


You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.


The most common side effects include headache, flushing, upper respiratory tract infection, abdominal pain, allergic reaction, chest pain, and diarrhea. If these symptoms bother you or do not go away, your doctor may suggest ways of preventing or reducing them. Some can be reduced by taking painkillers, drinking plenty of fluids, and avoiding alcohol.


Before taking Nitrofirst 30mg Tablet, tell your doctor if you have low blood pressure, glaucoma (increased pressure in the eye), kidney disease, or heart failure. Also, inform your doctor about any other medicines you are taking, as some may interact with this medicine or make it unsafe to use together. Do not take medicines for erectile dysfunction while using this medicine. If you are pregnant or breastfeeding, ask your doctor whether this medicine is suitable for you. Your doctor may regularly monitor your blood pressure and heart rate during treatment.

Uses of Nitrofirst Tablet

Benefits of Nitrofirst Tablet

Treatment of Angina (heart-related chest pain)
Angina is chest pain caused by reduced blood flow to the heart muscle, usually due to narrowed coronary arteries. Nitrofirst 30mg Tablet helps by relaxing and widening blood vessels, which improves blood flow and oxygen supply to the heart. This helps relieve chest discomfort and reduces the risk of angina attacks.

Side effects of Nitrofirst Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nitrofirst
  • Headache
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Upper respiratory tract infection
  • Abdominal pain
  • Allergic reaction
  • Chest pain
  • Diarrhea

How to use Nitrofirst Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nitrofirst 30mg Tablet may be taken with or without food.

How Nitrofirst Tablet works

Nitrofirst 30mg Tablet is a nitrate. It dilates peripheral arteries and veins. Dilation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing the workload of the heart. As a result, the heart muscle does not need as much blood and oxygen supply.

Quick tips

  • Take Nitrofirst 30mg Tablet exactly as prescribed and at the same time each day to maintain its effectiveness and reduce tolerance.
  • Nitrofirst 30mg Tablet may cause dizziness or light-headedness, so avoid driving or operating machinery until you know how it affects you.
  • Stand up slowly from sitting or lying positions, as this medicine may cause a drop in blood pressure and dizziness.
  • Avoid alcohol while taking Nitrofirst 30mg Tablet, as it may increase dizziness or light-headedness.
  • Headache is a common side effect when starting Nitrofirst 30mg Tablet, and it usually improves with continued use; inform your doctor if it becomes severe or persistent.
  • Do not take medicines for erectile dysfunction (such as sildenafil or tadalafil) while using Nitrofirst 30mg Tablet, as this combination can cause a dangerous drop in blood pressure.
  • Nitrofirst 30mg Tablet is usually used to prevent angina attacks and not for immediate relief; seek urgent medical attention if you develop sudden or severe chest pain.
  • Follow the prescribed dosing schedule carefully, as tolerance to nitrates may develop if dosing instructions are not followed properly.
  • Maintain heart-healthy lifestyle habits, such as a balanced diet, regular physical activity, weight control, stress reduction, and avoiding smoking.
  • Consult your doctor if you experience severe weakness, fainting, confusion, or persistent symptoms while taking Nitrofirst 30mg Tablet.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Nitrofirst 30mg Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Nitrofirst 30mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Nitrofirst 30mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Nitrofirst 30mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

SAFE IF PRESCRIBED
Nitrofirst 30mg Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.
However, talk to your doctor if you have any underlying kidney disease.
Liver

Liver

SAFE IF PRESCRIBED
Nitrofirst 30mg Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.

Interaction with drugs

Taking Nitrofirst with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Sildenafil (Oral Route)

Do not consume Sildenafil with Isosorbide Mononitrate. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Isosorbide Mononitrate. Please consult your doctor.
Life-threatening

Tadalafil (Oral Route)

Do not consume Tadalafil with Isosorbide Mononitrate. If Tadalafil is essential, ensure a gap of at least 48 hours between taking Tadalafil and Isosorbide Mononitrate.
Life-threatening

Sildenafil (Oral Route)

Do not consume Sildenafil with Isosorbide Mononitrate. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Isosorbide Mononitrate. Please consult your doctor.
Life-threatening

Sildenafil (Injection Route)

Do not consume Sildenafil with Isosorbide Mononitrate. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Isosorbide Mononitrate. Please consult your doctor.
Life-threatening

Sildenafil (Injection Route)

Do not consume Sildenafil with Isosorbide Mononitrate. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Isosorbide Mononitrate. Please consult your doctor.

Frequently asked questions

Nitrofirst 30mg Tablet is a medicine used to help prevent angina, which is chest pain caused by reduced blood flow to the heart. It works by relaxing and widening the blood vessels, allowing blood to flow more easily to the heart and reducing the heart’s workload. This helps prevent episodes of chest pain during daily activities. However, Nitrofirst 30mg Tablet is not intended to relieve sudden angina attacks once they have started. Because the medicine can lower blood pressure, some people may feel dizzy or light-headed, especially when standing up quickly.
Nitrofirst 30mg Tablet may affect heart rate in some people. Because the medicine lowers blood pressure by widening blood vessels, the body may respond by increasing the heart rate (reflex tachycardia) in some cases. These changes are usually mild, but if you notice a significant change in heart rate or feel unwell after taking the medicine, you should consult your doctor.
Nitrofirst 30mg Tablet may begin working the same day you start taking it, but its main purpose is to prevent angina over time rather than provide immediate symptom relief. The medicine releases its active ingredient slowly to maintain a steady protective effect. Because it works gradually, you may not feel any immediate difference even though it is helping protect your heart.
Nitrofirst 30mg Tablet is usually taken once daily in the morning unless your doctor recommends a different schedule. Taking it at the same time every day helps maintain a consistent effect in the body. Doctors often schedule the dose in a way that allows a daily nitrate-free interval, which helps prevent the body from becoming tolerant to the medicine. If your doctor prescribes it twice daily, the doses are usually spaced several hours apart.
If you forget to take a dose of Nitrofirst 30mg Tablet, take it as soon as you remember, as long as it is within about 12 hours of the scheduled time. If more than 12 hours have passed, skip the missed dose and take the next dose at the usual time. Do not take two doses at the same time to make up for a missed one.
Headache is one of the most common side effects of Nitrofirst 30mg Tablet. Some people may also experience flushing, dizziness, or symptoms of low blood pressure. These effects occur because the medicine widens blood vessels. Headaches often improve as the body adjusts to the medication. If headaches are severe or persistent, consult your doctor.
You should not stop taking Nitrofirst 30mg Tablet without consulting your doctor. Stopping the medicine suddenly may increase the risk of angina attacks. If you have concerns about side effects or the need for the medication, speak with your doctor before making any changes.
Taking more than the recommended dose of Nitrofirst 30mg Tablet may cause symptoms such as a severe throbbing headache, flushing of the skin, sweating, chills, nausea, vomiting, or a rapid heartbeat. If an overdose is suspected, seek emergency medical help immediately and contact your doctor.
While taking Nitrofirst 30mg Tablet, avoid using medicines for erectile dysfunction such as sildenafil, tadalafil, or vardenafil unless your doctor specifically approves them. Combining these medicines can cause a dangerous drop in blood pressure. Alcohol should also be limited because it may increase dizziness or light-headedness. Rise slowly from sitting or lying positions to reduce the risk of fainting.
Nitrofirst 30mg Tablet does not usually cause direct sleepiness. However, some people may feel dizzy or tired due to its blood pressure–lowering effect. If you feel faint or unsteady after taking the medicine, avoid driving or operating machinery until you feel better. If these symptoms persist, consult your doctor.
Nitrofirst 30mg Tablet is not commonly known to directly harm the kidneys or liver. However, if blood pressure drops too low or if dehydration occurs, kidney function may be affected in some people. Maintaining adequate fluid intake and following your doctor’s advice can help reduce this risk. If you notice reduced urination, repeated dizziness, or unusual symptoms while taking Nitrofirst 30mg Tablet, consult your doctor.

Fact Box

Chemical Class

Isosorbides

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Nitric Oxide (NO) Donors
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zyphar's Pharmaceuticals Pvt Ltd
Address: 102/103, Park Plaza, Opp. Kamla Nehru Park, Off. Bhandarkar Road, Pune - 411004, Maharashtra (India)

Vendor Details

Country of origin: India
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