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MRP: Rs. 110 for 1 tube(s) (20 GM gel each)
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Composition for NIOCLEAN

Clindamycin Topical(1% w/w),Nicotinamide(4% w/w)

food interaction for NIOCLEAN

alcohol interaction for NIOCLEAN

pregnancy interaction for NIOCLEAN

lactation interaction for NIOCLEAN

Avoid Nioclean 1%/4% gel with acidic food and beverages such as sugar, certain dairy products, fish, processed foods, fresh meats and processed meats,sodas and other sweetened beverages.
Interaction with alcohol is unknown. Please consult your doctor.
Human and animal studies are not available. Please consult your doctor.
Nioclean 1%/4% gel is probably safe to use during breastfeeding. Please consult your doctor.


Clindamycin Topical(1% w/w)


Clindamycin topical is used to treat severe acne (acne vulgaris) and vaginal infections caused by certain bacteria.

How it works

Clindamycin belongs to a class of medications called as lincomycin antibiotics. It inhibits the synthesis of essential bacterial proteins thereby stopping bacterial growth. In case of acne, in addition to killing of bacteria, clindamycin prevents spread of infection by reducing the free fatty acids on the skin surface that clog the pores of skin and promote overgrowth of bacteria.

Common side effects

Burning sensation, Application site irritation, Dry skin, Itching, Application site redness of skin
Nicotinamide(4% w/w)


Nicotinamide is used to treat vitamin B3 deficiency and inflammatory skin diseases like acne and pellagra.

How it works

Nicotinamide is an amide form of nicotinic acid. Nicotinamide is a component of two coenzymes, which help in tissue respiration and metabolism of  lipids, amino acids, proteins, and purines. Nicotinamide lowers blood cholesterol and triglyceride levels by inhibiting the synthesis of very low density lipoproteins.

Common side effects

Rash, Abnormal liver function tests, Allergic sensitization, Blurred vision, Diarrhoea, Dizziness, Flushing, Gastrointestinal discomfort, Vomiting, Nausea, Headache, Liver toxicity, Increased glucose level in blood


10 Substitutes
Sorted By
  • FACECLIN 1% W/W/4% W/W GEL
    (20 GM gel in tube)
    Abbott India Ltd
    Rs. 6.50/GM of gel
    Rs. 130
    pay 18% more per GM of gel
  • ACNESTAR 1% W/W/4% W/W GEL
    (15 GM gel in tube)
    Mankind Pharma Ltd
    Rs. 4.67/GM of gel
    Rs. 70
    save 15% more per GM of gel
  • FEMCINOL A 1% W/W/4% W/W GEL
    (20 GM gel in tube)
    Dabur India Ltd
    Rs. 5.40/GM of gel
    Rs. 108
    save 2% more per GM of gel
    (20 GM gel in tube)
    Glowderma Labs Pvt Ltd
    Rs. 6.15/GM of gel
    Rs. 123
    pay 12% more per GM of gel
    (20 GM gel in tube)
    Micro Labs Ltd
    Rs. 5.44/GM of gel
    Rs. 108.87
    save 1% more per GM of gel

Expert advice for NIOCLEAN

  • Discontinue use of topical clindamycin and contact your doctor immediately, if you experience diarrhea or bloody diarrhea.
  • Avoid vaginal intercourse or use of other intravaginal products such as tampons or douches while using clindamycin cream. 
  • Clindamycin cream contains mineral oil that may weaken latex products (condoms and diaphragms) and may not provide adequate birth control. Therefore, do not use these products within 72 hours of using clindamycin cream.
  • Avoid direct contact of cream with your eyes. In case of direct contact, wash your eyes with water and seek immediate medical attention.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not use if you are allergic to clindamycin, lincomycin or any of its ingredients.
  • Do not use if you have Crohn’s disease (a chronic inflammatory disease of the intestines), antibiotic-associated colitis (colon inflammation).

Frequently asked questions for NIOCLEAN

Clindamycin Topical

 Q. Can I use clindamycin with a penicillin allergy?
Clindamycin is considered safe for use in patients with a penicillin allergy.
Q. Does clindamycin treat acne scars?
Clindamycin can prevent the formation of new scars by preventing formation of new acne, but will not be useful for the scars already formed.
Q. Can clindamycin cream cause thrush?
Yes. Use of clindamycin cream may cause thrush (a type of fungal or yeast infection) in rare cases.


Q. Is nicotinamide safe?
Nicotinamide is safe if used as recommended. In case of any side effects, consult your doctor.

Q. Does nicotinamide contain nicotine?
No. Nicotinamide in no way contain nicotine. Nicotinamide is amide form of nicotinic acid and used to treat skin diseases like acne and pellagra.

Q. Is nicotinamide good for acne?
Yes. Nicotinamide when taken along with zinc and folic acid is a good treatment of acne.

Q. Is nicotinamide the same as niacin?
No. Nicotinamide is an amide form of nicotinic acid.

Q. Is nicotinamide available over the counter?
Yes. Nicotinamide is available over the counter. However, please consult your doctor regarding its use.

Q. Does nicotinamide cause flushing?
In case of overdose, nicotinamide may cause flushing or rash. Always follow the instructions of doctor regarding the dosage and duration.


Content on this page was last updated on 17 August, 2016, by Dr. Varun Gupta (MD Pharmacology)