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NICOTINE POLACRILEX 4MG CHEWING GUMS

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MRP: Rs. 79 for 1 packet(s) (9 chewing gums each)
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Composition for NICOTINE POLACRILEX

Nicotine(4mg)

food interaction for NICOTINE POLACRILEX

alcohol interaction for NICOTINE POLACRILEX

pregnancy interaction for NICOTINE POLACRILEX

lactation interaction for NICOTINE POLACRILEX

food
alcohol
pregnancy
lactation
No interaction found
No interaction found
Nicotine polacrilex 4mg chewing gums is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Nicotine polacrilex 4mg chewing gums is probably unsafe to use during breastfeeding. Please consult your doctor.
UNSAFE

SALT INFORMATION for NICOTINE POLACRILEX

Nicotine(4mg)

Uses

Nicotine polacrilex 4mg chewing gums is used in smoking addiction.

How it works

Nicotine polacrilex 4mg chewing gums is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, Nicotine polacrilex 4mg chewing gums binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of Nicotine polacrilex 4mg chewing gums. Nicotine polacrilex 4mg chewing gums also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.

Common side effects

Pale colored skin, Palpitations, Paresthesia (tingling or pricking sensation), Epileptic convulsion, Fainting, Increased glucose level in blood, Increased lactate level in blood, Increased depth of breathing, Decreased insulin level in blood, Increased sweating, Respiratory arrest, Tremor

SUBSTITUTES for NICOTINE POLACRILEX

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Content on this page was last updated on 23 September, 2016, by Dr. Varun Gupta (MD Pharmacology)