Product introduction
Neptaz-D 100 Tablet is a combination medicine used in heart failure. It helps reduce fluid buildup, relax blood vessels, and lower the workload on the heart, thereby improving symptoms and supporting better heart function.
Take Neptaz-D 100 Tablet regularly at the same time each day as prescribed by your doctor. Do not stop or change the dose without medical advice, even if you feel better. Monitor your weight and symptoms such as swelling or breathlessness regularly and report any sudden changes to your doctor. Follow a low-salt diet, limit fluid intake if advised, and keep regular follow-up visits to monitor kidney function, blood pressure, and overall heart status.
There is limited data on the side effects of Neptaz-D 100 Tablet. Let your doctor know if you experience any symptoms that bother you or worsen while taking the medicine. They can suggest ways to treat or manage the side effects.
Do not use this medicine if you are allergic to any of its components or if you have a history of angioedema related to similar medicines. Inform your doctor if you have diabetes, are taking diuretics, or are at risk of electrolyte imbalance. Seek medical attention if you experience severe dizziness, fainting, reduced urine output, or swelling of the face, lips, or throat.
Uses of Neptaz-D Tablet
Benefits of Neptaz-D Tablet
In Heart Failure
Heart failure is a condition in which the heart is unable to pump blood effectively, leading to symptoms such as breathlessness, fatigue, and fluid buildup in the body. Neptaz-D 100 Tablet helps improve heart function, reduce fluid overload, and ease the workload on the heart. This medicine helps relieve symptoms, improves exercise tolerance and quality of life, and supports better long-term heart health.
Side effects of Neptaz-D Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Neptaz-D
- Limited data available
How to use Neptaz-D Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Neptaz-D 100 Tablet may be taken with or without food.
How Neptaz-D Tablet works
Neptaz-D 100 Tablet is a combination of dapagliflozin, sacubitril, and valsartan. Sacubitril and valsartan work by improving the body’s protective mechanisms and blocking harmful pathways involved in heart failure. Sacubitril inhibits neprilysin, leading to increased levels of natriuretic peptides that promote vasodilation and help remove excess sodium and water. Valsartan blocks the effects of angiotensin II, which relaxes blood vessels and reduces fluid retention and cardiac workload. Dapagliflozin, an SGLT2 inhibitor, increases the excretion of glucose and sodium through urine. This leads to osmotic diuresis and a reduction in circulating fluid volume. Together, these actions help reduce congestion, lower cardiac stress, and improve overall hemodynamic balance in heart failure.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Neptaz-D 100 Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Neptaz-D 100 Tablet during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Neptaz-D 100 Tablet during breastfeeding is not available. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether Neptaz-D 100 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of Neptaz-D 100 Tablet in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited data available on the use of Neptaz-D 100 Tablet in patients with liver disease.
What if you forget to take Neptaz-D Tablet?
If you miss a dose of Neptaz-D 100 Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular schedule.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Neptaz-D 100 Tablet
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Cidmus-D 100 Tablet
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Quick tips
- Monitor your body weight daily at the same time. A sudden increase (for example, more than 1–2 kg over a few days) may indicate fluid retention and should be reported to your doctor promptly.
- Check your blood pressure regularly, especially during the initial weeks of treatment or after dose adjustments. If you experience persistent dizziness, lightheadedness, or fainting, seek medical advice.
- Maintain a low-salt diet, as excess sodium can worsen fluid retention and reduce the effectiveness of heart failure treatment. Avoid processed and packaged foods that are high in hidden salt.
- Inform your doctor immediately if you develop symptoms of dehydration (persistent vomiting, diarrhea, excessive sweating), as a temporary dose adjustment or interruption may be required.
Fact Box
Habit Forming
No
Therapeutic Class
CARDIAC
Patient concerns
FAQs
How long does it take to see improvement after starting this medicine?
Some patients may begin to notice relief in symptoms such as reduced swelling or improved breathing within a few weeks of regular use. However, heart failure treatment is intended for long-term disease control, and the full benefits develop gradually over time. It is important to continue the medication as prescribed, even if symptoms improve early.
Do I need to continue this medicine if my symptoms improve?
Yes. Heart failure is a chronic condition that requires ongoing treatment. Symptom improvement usually indicates that the medicine is working, not that the condition has resolved. Stopping or changing the dose without medical advice may lead to worsening symptoms or disease progression.
What lifestyle measures should be followed along with Neptaz-D 100 Tablet?
Neptaz-D 100 Tablet works best when combined with heart failure lifestyle management. Patients are usually advised to limit salt intake, monitor daily fluid intake if recommended, maintain a healthy weight, and stay physically active as tolerated. Regular follow-up visits are important to assess treatment response.
What should patients monitor at home while taking this medicine?
Patients should regularly monitor their body weight, blood pressure, and symptoms. Sudden weight gain, increasing leg swelling, worsening breathlessness, unusual fatigue, dizziness, or reduced urine output should be reported to a doctor, as these may indicate fluid retention or changes in heart function.
Who should use this medicine with caution?
Patients with low blood pressure, dehydration, or diabetes, or those taking diuretics or multiple heart medications, should inform their doctor before starting treatment. Dose adjustments or closer monitoring may be required in such cases.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Jiang J, Gao J, Zhang X, Li Y, Dang H, Liu Y, Chen W. Combined treatment with sacubitril/valsartan plus dapagliflozin in patients affected by heart failure with reduced ejection fraction. Front Cardiovasc Med. 2023 Mar 22;10:1097066. doi: 10.3389/fcvm.2023.1097066. PMID: 37034349; PMCID: PMC10073490. [Accessed 24/02/2026] (online) Available from:
- Meng P, Zhen C, Liu F, Li X. Dapagliflozin combined with sacubitril/valsartan promotes cardiac function recovery in elderly patients with acute myocardial infarction. Am J Transl Res. 2025 Sep 15;17(9):7482-7492. doi: 10.62347/QLUA3216. PMID: 41113014; PMCID: PMC12531515. [Accessed 24/02/2026] (online) Available from:
Marketer details
Name: Mankind Pharma Ltd
Address: 208, Okhla Industrial Estate, Phase III, New Delhi - 110020
Country of origin: India
Expires on or after: November, 2027
A licensed vendor partner from your nearest location will deliver Neptaz-D 100 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: November, 2027
A licensed vendor partner from your nearest location will deliver Neptaz-D 100 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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MRP₹400 10% OFF
₹361
Inclusive of all taxes
10.0 tablets in 1 strip
The price displayed is the MRP (inclusive of applicable taxes). Any additional fee (such as shipping fee, handling and/or platform fee etc.) will be clearly disclosed before you complete your purchase.
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