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Naprocine D Tablet

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 10 Dec 2025 | 01:00 AM (IST)
Naprocine D Tablet is a medicine used in the prevention of migraines. It inhibits the release of certain chemical messengers that cause pain, inflammation, and fever. It also blocks the signals in the brain that cause nausea and vomiting associated with migraines.
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Naprocine D Tablet
Naprocine D Tablet
strip of 10 tablets
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Naxpesure-Plus Tablet
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by Leeford Healthcare Ltd
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Naprocine D Tablet image
Naprocine D Tablet image
Naprocine D Tablet image
Naprocine D Tablet image
Naprocine D Tablet image
Naprocine D Tablet image

Product introduction

Naprocine D Tablet may be prescribed alone or in combination with another medicine. It can be taken with or without food. The dose and duration will depend on the severity of your condition and how well it helps your symptoms. Use it regularly and do not discontinue it until the doctor tells you it is right to stop.


Using Naprocine D Tablet may cause common side effects such as headaches, ringing in the ears, dizziness, tiredness, rashes, and vision changes. If you experience such side effects that do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.


In general, you should try to use the smallest amount necessary to control your symptoms. Before using the medicine, you should tell your doctor if you have any other illnesses or disorders. It may also affect, or be affected by, some other medicines you are using, so let your doctor know all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctors first before using the medicine.

Uses of Naprocine D Tablet

Benefits of Naprocine D Tablet

Prevention of Migraine
Naprocine D Tablet blocks chemicals responsible for pain sensation and also blocks signals that cause nausea/vomiting associated with migraines. By preventing and reducing the frequency of migraine headaches, it can help you carry out your daily activities and have a better quality of life.

Side effects of Naprocine D Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Naprocine D
  • Headache
  • Ringing in ear
  • Altered vision
  • Tiredness
  • Dizziness
  • Drowsiness
  • Rash

How to use Naprocine D Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Naprocine D Tablet may be taken with or without food.

How Naprocine D Tablet works

Naprocine D Tablet is a combination of two medicines: naproxen and domperidone. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause pain due to migraine. Domperidone works on the region in the brain that controls vomiting associated with migraine. Together, they provide relief from migraine symptoms.

Quick tips

  • Do not take it to treat an acute attack of migraine.
  • Some tips that may help avoid a migraine attack include eating your meals at the same time every day, avoiding bright lights and extreme temperatures, avoiding loud music and noisy places, and abstaining from chocolates, cheese, processed food, alcohol, and smoking.
  • Naprocine D Tablet may cause dizziness. Do not drive or do anything that requires mental focus until you know how Naprocine D Tablet affects you.
  • Take Naprocine D Tablet as prescribed by your doctor, even if your symptoms go away.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Naprocine D Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Naprocine D Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.
Driving

Driving

UNSAFE
Naprocine D Tablet may cause side effects that could affect your ability to drive.
Naprocine D Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.
Kidney

Kidney

CAUTION
Naprocine D Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Naprocine D Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Naprocine D Tablet is not recommended in patients with moderate and severe liver disease.

Frequently asked questions

Naprocine D Tablet is a combination of two medicines used to relieve migraine symptoms such as headache, nausea, and vomiting. Naproxen works by blocking chemical messengers responsible for pain and inflammation. Domperidone helps prevent nausea and vomiting by improving gut movement and acting on the brain’s vomiting center. Together, they provide effective relief from both headache and associated stomach discomfort during migraines.
Yes, the use of Naprocine D Tablet can cause diarrhea. In case you experience diarrhea, drink plenty of water or other fluids. Talk to your doctor if diarrhea persists and you notice any signs of dehydration, like less urination with dark-colored and strong-smelling urine. Do not take any other medicine without consulting a doctor.
The use of Naprocine D Tablet is considered to be harmful for patients with known allergies to any of the components or excipients of this medicine or in patients with known allergies to other painkillers belonging to NSAIDs. The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or patients with active, recurrent stomach ulcers/bleeding. It should also be avoided in patients with a history of heart failure, high blood pressure, and liver or kidney disease.
Yes, the long-term use of Naprocine D Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protects them from damage. The use of painkillers lowers the levels of prostaglandins in the body, which leads to kidney damage on long-term use. The use of painkillers is not recommended for patients with underlying kidney disease.

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NEURO CNS
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Metacine Pharmaceuticals Pvt Ltd
Address: S.No.3,Near Podar International School,Ambegaon(Budruk),Katraj Dehu Road Bypass,Pune-411046

Vendor Details

Country of origin: India
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