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Naproxen + Domperidone

Written By Dr. Lipika KhuranaReviewed By Dr. Rajeev Sharma
Last updated 25 Nov 2025 | 09:37 AM (UTC)

Naproxen + Domperidone Uses

Naproxen+Domperidone is used to prevent migraine.

Available generics for Naproxen + Domperidone

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How Naproxen + Domperidone works

Naproxen + Domperidone is a combination of two medicines: Naproxen and Domperidone. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause pain due to migraine. Domperidone is a prokinetic which works on the region in the brain that controls vomiting associated with migraine. It also increases the movement of the stomach and intestines, allowing food to move more easily through the stomach.

Common side effects of Naproxen + Domperidone

Dryness in mouth, Headache, Heartburn, Abdominal pain, Nausea, Vomiting, Flatulence, Constipation, Diarrhea, Dyspepsia, Epigastric pain, Dark colored stool, Hematemesis (vomiting blood), Ulcerative stomatitis, Exacerbation of colitis, Crohn's disease, Dizziness, Drowsiness, Itching, Skin eruptions, Ringing in ear, Edema (swelling), Breathlessness
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Expert advice for Naproxen + Domperidone

  • You have been prescribed Naproxen + Domperidone for prevention of migraine headaches.
  • Do not take it to treat an acute attack of migraine.
  • Some tips that may help avoid a migraine attack:
    • Have your meals at the same time everyday
    • Avoid bright lights and extreme temperatures
    • Avoid loud music and noisy places
    • Avoid chocolates,  cheese, processed food, alcohol and smoking
    • Get enough sleep and avoid stress
  • It may cause sleepiness. Do not drive or do anything that requires mental focus until you know how Naproxen + Domperidone affects you.
  • Avoid consuming alcohol as it may cause new and worse headaches.
  • Keep taking it every day, as prescribed by your doctor, even if you do not have any symptoms.

Frequently asked questions for Naproxen + Domperidone

Naproxen+Domperidone is a combination of two medicines: Naproxen and Domperidone. This combination helps in relieving the symptoms of migraine like headache, nausea and vomiting. Naproxen is a pain-killer that blocks the release of certain chemical messengers that cause headache. Domperidone is an anti-emetic agent (prokinetic). It increases the movement of the stomach and intestines, allowing food to move more easily through the stomach. This helps in relieving vomiting.
Yes, the use of Naproxen+Domperidone can cause diarrhea. In case, you experience diarrhea, drink plenty of water or other fluids. Talk to your doctor if diarrhea persists and you notice any signs of dehydration, like less urination with dark coloured and strong-smelling urine. Do not take any other medicine without consulting a doctor.
The use of Naproxen+Domperidone is considered to be harmful for patients with known allergy to any of the components or excipients of this medicine or in patients with known allergy to other painkillers (NSAIDs). The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer/bleeding. It should also be avoided in patients with history of heart failure, high blood pressure, and liver or kidney disease.
Yes, the long-term use of Naproxen+Domperidone can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protects them from damage. Use of painkillers lower the levels of prostaglandins in the body, which leads to kidney damage on long-term use. Use of painkillers is not recommended to patients with underlying kidney disease.
No, do not stop taking Naproxen+Domperidone until advised by your doctor.